Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying Severity

1990 ◽  
Vol 79 (2) ◽  
pp. 161-165 ◽  
Author(s):  
A. M. Cruickshank ◽  
W. D. Fraser ◽  
H. J. G. Burns ◽  
J. Van Damme ◽  
A. Shenkin
Keyword(s):  
Interleukin 6 ◽  
Elective Surgery ◽  
Venous Blood ◽  
Surgical Trauma ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Duration Of Surgery ◽  
Minor Surgery ◽  
Protein Response ◽  
Major Vascular Surgery

1. Recent studies have suggested that interleukin-6 is a major mediator of the acute-phase protein response in man. The aim of the present study was to investigate the relationships between the response of serum interleukin-6 to surgery, the type of surgical procedure performed and the response of serum C-reactive protein. 2. Timed venous blood samples were taken from 26 patients in five broad surgical categories (minor surgery, cholecystectomy, hip replacement, colorectal surgery and major vascular surgery). C-reactive protein and interleukin-6 were measured in each sample. 3. Serum interleukin-6 rose within 2–4 h of incision in all patients and the magnitude of the response differed among the various surgical groups. The response of interleukin-6 correlated (r = 0.80, P < 0.001) with the duration of surgery. In contrast, serum C-reactive protein was not detectable after minor surgery (< 10 mg/l) and the response of C-reactive protein did not differ among the more major surgical groups. The response of interleukin-6 showed a weak, but significant, correlation with the response of C-reactive protein (r = 0.67, P < 0.001). 4. We conclude that serum interleukin-6 is a sensitive, early marker of tissue damage. In general, the greater the surgical trauma, the greater the response of serum interleukin-6 and the greater the peak serum concentration of interleukin-6. Our results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis.

Increases in circulating levels of monocyte–platelet and neutrophil–platelet complexes following hip arthroplasty

2002 ◽  
Vol 102 (3) ◽  
pp. 279-286
Author(s):  
A. BUNESCU ◽  
J. WIDMAN ◽  
R. LENKEI ◽  
P. MENYES ◽  
K. LEVIN ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Platelet Activation ◽  
Hip Arthroplasty ◽  
Interleukin 6 ◽  
Tissue Injury ◽  
Surgical Trauma ◽  
C Reactive Protein ◽  
Prothrombin Fragment ◽  
Reactive Protein ◽  
Duration Of Surgery

Platelets and leucocytes are important effector cells of the haemostatic and inflammatory responses to tissue injury. To investigate the effects of surgical trauma on platelet activation (assessed by measuring levels of P-selectin and β-thromboglobulin), leucocyte activation (CD11b expression) and leucocyte-platelet interactions (leucocyte-platelet complexes), 30 patients undergoing primary hip arthroplasty were studied before and at the end of surgery, and on days 1 and 10 post-operatively, using a whole-blood flow cytometry assay. The inflammatory response was followed by measurement of the levels of C-reactive protein and interleukin-6 in plasma, and the activation of coagulation was monitored by determination of prothrombin fragment 1+2 levels. On day 1 post-operatively a significantly increased expression of CD11b on monocytes was noted, but no direct correlation was found between monocyte activation and interleukin-6 production or C-reactive protein at this time point. The percentage of monocyte-platelet and neutrophil-platelet complexes was markedly increased on day 10 post-operatively compared with pre-operative levels, and levels of these complexes were significantly positively correlated with β-thromboglobulin levels. Activation of coagulation (prothrombin fragment 1+2) on day 10 post-operatively was positively correlated with the extent of surgical trauma (duration of surgery, amount of blood loss) and with the increase in platelet activation (β-thromboglobulin). In conclusion, hip arthroplasty induces platelet and coagulation activation, and also an inflammatory response that is maintained for more than 10 days post-operatively. This indicates an interaction between the immune and the haemostatic systems in the post-operative phase after hip arthroplasty.

scholarly journals Evaluation of Serum Interleukin-6 and C-Reactive Protein Levels among Women During Term Labour

2020 ◽  
pp. 69-76
Author(s):  
Ubongabasi A. James ◽  
John O. Imaralu ◽  
Ijeoma Esiaba
Keyword(s):  
Interleukin 6 ◽  
Venous Blood ◽  
University Teaching ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Blood Samples ◽  
Reactive Protein ◽  
Significant Difference ◽  
Term Labour

Aims: To determine the serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6) as well as level of leukocytosis, as inflammatory contributory factors in women with uncomplicated term pregnancies before, during and after labour. Study Design:  This is a cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Obstetrics and Gynaecology of Babcock University Teaching Hospital (BUTH) and Department of Biochemistry, Babcock University, Ogun State Nigeria between June 2019 and February 2020. Methodology: 45 venous blood samples were obtained from 34 selected women and grouped into three; prenatal (≥ 32 weeks, n = 18), labour (4 to 6 cm dilation, n = 12) and postnatal (≤ 24 hour postpartum, n = 15). Sixteen blood samples were also obtained from the umbilical cord. Levels of CRP and IL-6 were determined by Enzyme Linked Immunosorbent Assay (ELISA) techniques and the leukocyte count, by hematologic method. Differences in statistical mean were evaluated by one way analysis of variance (ANOVA) with Bonferroni post hoc comparison. The level of significance was set at P < 0.05. Results: Concentration of serum IL-6 was significantly high during labour (1354.79 ± 189.16 pg/mL) compared to the prenatal (14.94 ± 4.86 pg/mL, P < .001) and postnatal (13.17 ± 3.06 pg/mL, P < .001) periods. The low level of CRP observed during active labour compared to the prenatal and postnatal periods did not reach significant difference. The levels of these inflammatory markers were low in the cord blood. Leukocyte counts (P = .011) as well as neutrophils (P = .014) and MID cell fractions (P = .004) were significantly higher during the postnatal period. Conclusion: The high levels of serum IL-6 observed in this study supports human term labour as an inflammatory event not associated with increased leukocytosis.

Changes in Plasma Metallothionein-1, Interleukin-6, and C-Reactive Protein in Patients After Elective Surgery

1997 ◽  
Vol 43 (5) ◽  
pp. 845-847 ◽  
Author(s):  
Durojaye F Akintola ◽  
Barry Sampson ◽  
Jacky Burrin ◽  
Adam Fleck ◽  
Christopher Price ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Elective Surgery ◽  
C Reactive Protein ◽  
Reactive Protein

C-Reactive Protein, Interleukin 6, and N-Terminal Pro-Brain Natriuretic Peptide Following Cardioversion of Atrial Fibrillation: Is There a Role of Biomarkers in Arrhythmia Recurrence?

Angiology ◽  
2010 ◽  
Vol 62 (4) ◽  
pp. 310-316 ◽  
Author(s):  
Stavroula N. Psychari ◽  
Dionyssios Chatzopoulos ◽  
Efstathios K. Iliodromitis ◽  
Thomas S. Apostolou ◽  
Dimitrios T. Kremastinos
Keyword(s):  
Atrial Fibrillation ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Reactive Protein
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