Rod mediated retinal dysfunction in cats with zinc depletion: Comparison with taurine depletion

1986 ◽  
Vol 71 (5) ◽  
pp. 559-564 ◽  
Author(s):  
S. G. Jacobson ◽  
N. J. Meadows ◽  
P. W. N. Keeling ◽  
W. D. Mitchell ◽  
R. P. H. Thompson
Keyword(s):  
Wave Amplitude ◽  
Zinc Supplementation ◽  
Zinc Content ◽  
Retinal Dysfunction ◽  
Zinc Depletion ◽  
Zinc Levels

1. Cats fed for 4 months with a diet with less than 7 p.p.m. zinc developed tissue zinc depletion, as judged by reduced muscle zinc content. 2. Dark adapted electroretinogram (ERG) thresholds became elevated in zinc depleted cats. Electroretinograms and muscle zinc levels were reversed by zinc supplementation. 3. Rod ERG to suprathreshold stimuli became reduced in b-wave amplitude in cats with zinc depletion, but suprathreshold cone ERG were unchanged. 4. The ERG changes in zinc depleted cats were unlike those in cats fed on a taurine depleted diet.

Influence of Applied Phytosanitary Treatments and Climatic Crop Year on Zinc Content in Wines from Tohani Vineyard

2017 ◽  
Vol 68 (9) ◽  
pp. 2092-2097
Author(s):  
Catalina Calin ◽  
Gina Vasile Scaeteanu ◽  
Roxana Maria Madjar ◽  
Otilia Cangea
Keyword(s):  
Zinc Content ◽  
Soil Samples ◽  
Limit Set ◽  
Red Wines ◽  
Metallic Ions ◽  
Sauvignon Blanc ◽  
Before And After ◽  
Haze Formation ◽  
Zinc Levels ◽  
Concentration Levels

Metallic ions present a great importance in oenological practice and usually are present in wines in levels that are not hazardous. Among all metallic ions, zinc presents a great interest because may cause the persistence of the wine sour taste and by the side of Al, Cu, Fe and Ni, contribute to the haze formation and the change of color. The present study was focused on measuring the concentration levels of mobile zinc from vineyard soil before and after phytosanitary treatments and zinc content from white (Feteasca Alba - FA, Riesling Italian - RI, Sauvignon Blanc - SB, Tamaioasa Rom�neasca - TR), rose (Busuioaca de Bohotin - BB) and red (Feteasca Neagra - FN) wines within the wine-growing Tohani area, Romania. Other objective was to investigate of the influence of crop year and variety on zinc levels found in wine samples. Mobile zinc content for all analyzed soil samples is low ([1.5 mg/kg). Analyses indicated that zinc content found in wines was below 5 mg/L, limit set by Organisation Internationale of Vine and Wine (OIV). Also, it was found that red wines contain zinc in higher concentrations than white ones.

scholarly journals Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant

2021 ◽  
Vol 13 (3) ◽  
pp. 444-449
Author(s):  
Giovanna D’Amico ◽  
Corinne De Laet ◽  
Guillaume Smits ◽  
Deborah Salik ◽  
Guillaume Deprez ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Premature Infants ◽  
Zinc Supplementation ◽  
Good Prognosis ◽  
Acrodermatitis Enteropathica ◽  
Born Infant ◽  
Laboratory Investigations ◽  
Zinc Levels ◽  
Breast Fed ◽  
Low Serum

We present a case of a transient acquired zinc deficiency in a breast-fed, 4-month-old-male prematurely born infant, with acrodermatitis enteropathica-like symptoms such as crusted, eroded, erythemato-squamous eruption in periorificial and acral patterns. The laboratory investigations showed low zinc levels in the infant’s and the mother’s serum and in the mother’s milk; genetic analysis did not show any mutation in the SLC39A4 gene, involved in acrodermatitis enteropathica. Acquired zinc deficiency is often found in premature infants because of their increased requirement, the low serum and milk zinc levels in breastfeeding women being also an important risk factor, as in this case. A prompt zinc supplementation is essential for the good prognosis of the disease.

Zinc depletion reduced Egr-1 and HNF-3β expression and apolipoprotein A-I promoter activity in Hep G2 cells

2002 ◽  
Vol 283 (2) ◽  
pp. C623-C630 ◽  
Author(s):  
Libin Cui ◽  
Norberta W. Schoene ◽  
Lei Zhu ◽  
Jessica C. Fanzo ◽  
Ali Alshatwi ◽  
...  
Keyword(s):  
Promoter Activity ◽  
Basal Medium ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Apolipoprotein A ◽  
Zinc Depletion ◽  
Dna Contents ◽  
G2 Cells ◽  
Zinc Levels ◽  
Cellular Zinc

We examined the influence of zinc status on expression of certain transcription factors involved in regulation of apolipoprotein A-I (apoAI) expression in human hepatoblastoma Hep G2 cells. A low zinc basal medium (zinc deficient, ZD) consisting of DMEM and 10% Chelex100-treated fetal bovine serum was used to deplete cellular zinc over one passage. Cells were also cultured for one passage in medium supplemented with 0.4 (ZD0.4), 4.0 (zinc normal, ZN), 16.0 (zinc adequate, ZA), or 32.0 μM zinc (zinc supplemented, ZS). Compared with ZN cells, cellular zinc levels were 43 and 31% lower in ZD and ZD0.4 cells but 70 and 146% higher in ZA and ZS cells, respectively. Supplementation of 0.4 μM zinc significantly increased DNA contents per plate, from 65% in ZD cells to 83% in ZD0.4 cells compared with ZN cells. Addition of >4 μM zinc in medium did not further increase DNA contents. The proportion of cells in G1/S and S phase was about fourfold higher and threefold lower, respectively, in ZD cells compared with ZN and other groups. Nuclear Egr-1 protein was markedly decreased in ZD and ZD0.4 cells. Moreover, hepatocyte nuclear factor (HNF)-3β was severely degraded in ZD and ZD0.4 cells. In contrast, HNF-4α remained stable in all groups and was not significantly lower in ZD and ZD0.4 cells. Furthermore, downregulation of trans-acting factor Egr-1 and cleavage of HNF-3β were associated with reduction of apoAI promoter activity in zinc-deficient Hep G2 cells. Thus zinc is critical in transcriptional regulation of apoAI gene expression in hepatocytes.

scholarly journals The Effect of Biscuits Made From Pumpkin Seeds Flour on Serum Zinc Levels and Weight in Malnutrition Wistar Rats

2020 ◽  
Vol 8 (A) ◽  
pp. 428-433
Author(s):  
Aminuddin Syam ◽  
Fitrah Khaerani Burhan ◽  
Veni Hadju ◽  
C. Citrakesumasari ◽  
Andi Muhammad Akhmar
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Serum Zinc ◽  
Zinc Content ◽  
Control Group ◽  
Test Results ◽  
Pumpkin Seed ◽  
Seed Flour ◽  
Zinc Levels ◽  
Serum Zinc Levels

BACKGROUND: Serum zinc levels are found to be low in children of protein energy malnutrition globally. Pumpkin seed flour has a high zinc content of 6.88 mg/100 g, has been formulated biscuits made from pumpkin seed flour with a zinc content of 1.52 mg/100 g. AIM: This study aims to determine the effect of giving biscuits made from pumpkin seed flour to serum zinc levels and body weight in malnutrition Wistar rats. METHODS: This research is a true experiment with pre-post-test with control group design. Subjects were 28 male Wistar strain rats induced by fasting malnutrition for 3 days and then given biscuits with a zinc dose of 0.027 mg; 0.054 mg; and 0.081 mg/BW/day and in the control group without biscuits for 2 weeks. Serum zinc levels were examined using the atomic absorption spectrophotometry method. Data were analyzed using paired t-test and one-way ANOVA test. RESULTS: Paired t-test results on serum zinc levels obtained p > 0.05 and on body weight obtained p < 0.05. One-way ANOVA test results on serum zinc levels after the intervention obtained p > 0.05 and at body weight obtained p < 0.05 followed by post hoc least significant difference test found that there were significant differences between the control group and the P1 group, a dose of 0.027 mg (p = 0.015) and P2 groups, doses of 0.054 mg (p = 0.012). Greater weight gain was found in the P1 group with an increase of 38.85%. CONCLUSION: The provision of biscuits made from pumpkin seed flour has an effect on increasing body weight of malnutrition Wistar rats and has no effect on serum zinc levels, so further research is expected to use different doses.

scholarly journals Role and effects of zinc supplementation in HIV-infected patients with immunovirological discordance: A randomized, double blind, case control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244823
Author(s):  
Macarena Silva ◽  
Carmen G. Montes ◽  
Andrea Canals ◽  
Maria J. Mackenna ◽  
Marcelo Wolff
Keyword(s):  
Zinc Supplementation ◽  
Group Versus ◽  
Cd4 Count ◽  
Control Group ◽  
Immune Recovery ◽  
Plasma Zinc ◽  
Absolute Increase ◽  
Number Of Patients ◽  
Significant Difference ◽  
Zinc Levels

Introduction It has been estimated that between 15% and 18% of patients who start antiretroviral therapy (ART) do not achieve a successful immune recovery despite complete virological suppression. In the literature this phenomenom is known as poor immune recovery or immunovirological discordance (IVD). Zinc has an immunomodulatory role associated with T lymphocytes and its supplementation could enhance immune recovery. Objective To determine if zinc supplementation on IVD patients prevents immune failure after 12 months of supplementation. Secondary objectives were to determine serum zinc levels in HIV patients with and without IVD and the frequency of hypozincemia in discordant patients. Method We reviewed the historical record of patients under care at Arriarán Foundation. Following inclusion criteria were defined: 1) age ≥ 18 years, 2) standard ART (three effective drugs) for at least 18 months, 3) virologically suppressed for 12 months, 3) persistence of CD4 count ≤200 cells/mm3 and/or increase ≤ 80 cells/mm3 after one year of viral undetectability. A control group was assigned paired 1:1 by sex, age (± 2 years) that did achieved an increase of CD4> 350 cells/ mm3. In both groups plasma zinc levels were determined. In a later phase, patients with IVD were randomized to receive zinc (15 mg daily) versus placebo. Patients were followed for 12 months with CD4 count, viral load and zinc levels determinations every 4–6 months. Results A total of 80 patients, 40 patients with IVD criteria and 40 controls were included. 92.5% were men, and age average was 47.5 years. The median baseline CD4 was 189 cells/mm3 (71–258) in the cases vs. 552.5 cells/ mm3 (317–400) in the control group with a median increase at the end of the study of 39 cell/mm3 and 19 cell/mm3 respectively. There was no difference in baseline plasma zinc levels between both groups (81.7 + 18.1 in cases versus 86.2 + 11.0 in controls). In the 40 patients with IVD, the median absolute increase in CD4 after annual zinc supplementation was 31.5 cells/mm3 in the treated group versus 50 cells/mm3 in the placebo group, this difference being statistically not significant (p = 0.382). Conclusions Patients with IVD have plasma zinc levels similar to those who achieve adequate immune recovery. Zinc supplementation in IVD patients showed a statistically non-significant difference in in CD4 levels between cases and controls. The results warrant a comparative study with a larger number of patients.

Changes in plasma zinc content after exercise in men fed a low-zinc diet

1984 ◽  
Vol 247 (1) ◽  
pp. E88-E93 ◽  
Author(s):  
H. C. Lukaski ◽  
W. W. Bolonchuk ◽  
L. M. Klevay ◽  
D. B. Milne ◽  
H. H. Sandstead
Keyword(s):  
Copper Content ◽  
Maximal Exercise ◽  
Strong Predictor ◽  
Zinc Content ◽  
Plasma Zinc ◽  
Zinc Depletion ◽  
Plasma Copper ◽  
Zinc Concentrations ◽  
Zinc Repletion ◽  
Zinc Balance

For 30 days five healthy men aged 23-57 yr consumed a diet adequate in zinc (8.6 mg/day); they ate a low-zinc diet (3.6 mg/day) for the next 120 days and then received a zinc-supplemented (33.6 mg/day) diet for 30 days. Copper intake was constant at 1.8 mg/day. Aerobic capacity was determined periodically during each diet period. Relative zinc balance (% of control) declined during depletion (r = -0.28, P less than 0.009). Pre- and postexercise zinc concentrations decreased when dietary zinc was restricted (r = -0.61, P less than 0.0001 and r = -0.78, P less than 0.0001) and increased with supplementation (r = 0.61, P less than 0.008 and r = 0.76, P less than 0.0003, respectively). Both plasma zinc and hematocrit increased (P less than 0.01) after maximal exercise. To minimize the effect of hemoconcentration during exercise, the van Beaumont quotient (J. Appl. Physiol. 34: 102-106, 1973) was calculated using pre- and postexercise hematocrit and plasma zinc. The initial quotient of 1.8 +/- 1.8% (mean +/- SE) declined (P less than 0.05) to -7.4 +/- 2.3% during depletion. With zinc repletion, the quotient increased to 6.9 +/- 3.6%, which was greater (P less than 0.05) than the quotient in depletion but similar to the initial quotient. The quotient was a strong predictor (r = 0.71, P less than 0.0005) of the change in relative zinc balance during zinc depletion. In contrast, no changes were found in plasma copper content. These data suggest that zinc mobilization from tissues is impaired during zinc depletion, and they validate the use of the van Beaumont quotient as an index of change in body zinc stores.

scholarly journals The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial

2016 ◽  
Vol 48 (6) ◽  
pp. 374
Author(s):  
K. Suarca ◽  
Hendra S ◽  
B. N. P. Arhana ◽  
I K. G. Suandi
Keyword(s):  
Placebo Group ◽  
Hepatitis B ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Hepatitis B Vaccination ◽  
Double Blind ◽  
Baseline Serum ◽  
Zinc Supplements ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background Suboptimal zinc intake may depress thymus function,lymphoproliferation, and T cell-dependent B-cell proliferation,which can impair antibody production. Zinc supplementation canimprove immune function and reduce morbidity.Objective To assess the effect of zinc supplementation on infants'anti-HBs titer after hepatitis B vaccination.Methods A double-blind randomized control trial of 66 healthyinfants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjectswere followed from birth to three months of age and were placedinto two treatment groups using block randomization. One groupreceived zinc supplements with a standard hepatitis B vaccination(zinc group, n=33) and the other group received placebosupplements with standard hepatitis B vaccination (placebo group,n=33). The serum zinc levels were measured at baseline and atthree months. The difference in levels of anti-HBs titer between thezinc and placebo groups was the primary endpoint of this study.Results The serum zinc levels were significantly higher in the zincgroup compared to the placebo group (P = 0.017), with a meandifference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardlessof baseline serum zinc levels, the mean anti-HBs titers weresignificantly higher in the zinc group compared to the placebogroup (P <0.0001; mean difference = 495.8 miU/mL; 95%CI 362.32 to 629.44). Multivariate analysis showed that zincsupplementation was the only variable that influenced anti-HBstiter levels (P < 0.0001).Conclusion Regardless of their initial zinc serum level, infantsreceiving zinc supplements along with standard hepatitis Bvaccination have significantly higher levels of anti-HBs titersthan infants receiving hepatitis B vaccination without zincsupplements.

scholarly journals Influence of Dietary Phosphorus and Zinc Levels on Whole Body Mineral, Liver Mineral, and Liver Vitamin-C Contents of Fingerling Rainbow Trout, Oncorhynchus mykiss

1970 ◽  
pp. 135-142
Author(s):  
MS Alam Sarker ◽  
Shuichi Satoh
Keyword(s):  
Rainbow Trout ◽  
Vitamin C ◽  
Zinc Supplementation ◽  
Whole Body ◽  
Average Weight ◽  
Liver Copper ◽  
Dietary Phosphorus ◽  
Significant Difference ◽  
Zinc Levels ◽  
Liver Vitamin

A laboratory based 2 × 2 factorial experiment was conducted to investigate the influence of dietary phosphorus and zinc levels on whole body mineral, liver mineral, and liver vitamin-C contents of fingerling rainbow trout for 21 weeks. Two levels of phosphorus (19 and 30 mg g-1) and two levels of zinc (55 and 100 μ g g-1) in the dry diets were tested. Duplicate tanks of 30 rainbow trout (average weight 1.56 ± 0.24 g) per 60L glass tank were fed experimental diets three times a day to satiation level in 15 to 24oC water temperature. The result of the present study demonstrated that dietary zinc supplementation significantly influenced the whole body zinc and liver copper contents in fingerling rainbow trout where as additional phosphorus did not show any significant difference. Zinc supplementation significantly influenced the liver vitamin-C contents of the fish. Hence it is clear that zinc supplementation is necessary in fingerling rainbow trout feed. Further studies in this area are needed broadly. Key words: Phosphorus, zinc, whole body, liver mineral, liver vitamin-C, rainbow trout DOI = 10.3329/jard.v5i1.1470 J Agric Rural Dev 5(1&2), 135-142, June 2007

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