Regional Lung Haematocrit in Man Using Positron Emission Tomography (PET)

1985 ◽  
Vol 68 (s11) ◽  
pp. 60P-61P
Author(s):  
L. H. Brudin ◽  
S. O. Valind ◽  
C. G. Rhodes ◽  
T. Suzuki ◽  
D. Turton ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Positron Emission ◽  
Regional Lung

Regional lung hematocrit in humans using positron emission tomography

1986 ◽  
Vol 60 (4) ◽  
pp. 1155-1163 ◽  
Author(s):  
L. H. Brudin ◽  
S. O. Valind ◽  
C. G. Rhodes ◽  
D. R. Turton ◽  
J. M. Hughes
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Venous Blood ◽  
Normal Subjects ◽  
Emission Tomography ◽  
Thoracic Wall ◽  
Positron Emission ◽  
Regional Lung ◽  
Volume Measurements ◽  
Regional Blood Volume

Regional lung hematocrit ratio (R) was measured in five normal subjects and five patients (2 with pneumonia, 2 with nephrotic syndrome with anemia, and 1 with pancreatitis) using positron emission tomography, a red cell marker 11CO, and a plasma marker [methyl-11C]albumin). The measurements were made in a transaxial thoracic section at midheart level with the subject in supine posture and with a spatial resolution of 1.7 cm. The normal regional hematocrit ratio (means +/- SE) calculated for the lung was 0.90 +/- 0.014, 0.94 +/- 0.023 for the thoracic wall, and 1.00 +/- 0.003 for the heart chambers. The regional lung hematocrit ratio in the patients ranged between 0.81 and 0.86. No correlation was found among the regional lung hematocrit ratio and regional blood volume, lung extravascular density, and the peripheral hematocrit (obtained from venous blood samples). To the extent that 70% of the pulmonary blood in the field of view is in larger vessels with normal hematocrit, the hematocrit in the capillary bed is approximately two-thirds that of the peripheral venous value. Blood volume measurements on the basis of single vascular tracers need to take account of these results.

scholarly journals Ion beam induced 18F-radiofluorination: straightforward synthesis of gaseous radiotracers for the assessment of regional lung ventilation using positron emission tomography

2016 ◽  
Vol 52 (80) ◽  
pp. 11931-11934 ◽  
Author(s):  
V. Gómez-Vallejo ◽  
A. Lekuona ◽  
Z. Baz ◽  
B. Szczupak ◽  
U. Cossío ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Proton Irradiation ◽  
Ion Beam ◽  
Lung Ventilation ◽  
Emission Tomography ◽  
Positron Emission ◽  
Regional Lung ◽  
Cyclotron Target ◽  
Regional Lung Ventilation

[18F]CF4 and [18F]SF6 are produced in a cyclotron target under proton irradiation. [18F]CF4 is suitable for assessing lung ventilation.

Regional changes in extravascular lung water detected by positron emission tomography

1986 ◽  
Vol 60 (4) ◽  
pp. 1170-1178 ◽  
Author(s):  
D. P. Schuster ◽  
G. F. Marklin ◽  
M. A. Mintun
Keyword(s):  
Positron Emission Tomography ◽  
Cardiac Output ◽  
Left Atrium ◽  
Extravascular Lung Water ◽  
Indicator Dilution ◽  
Emission Tomography ◽  
Lung Water ◽  
Positron Emission ◽  
Regional Lung ◽  
Regional Blood Volume

Regional measurements of extravascular lung water (rEVLW) were made with positron emission tomography (PET) and 15O-labeled radionuclides. The label used to measure the total lung water (TLW) content fully equilibrated with TLW prior to scanning in both dogs with normal and low cardiac outputs, and nearly so in areas of lung made edematous by oleic acid injury (the TLW values used were 97% of maximum values). Regional EVLW measurements made by PET (EVLW-PET) and gravimetric techniques in both normal and edematous lung were closely correlated (r = 0.93), and EVLW-PET increased from an average of 0.20 to 0.37 mlH2O/ml lung (P less than 0.05) after regional lung injury. PET measurements of regional blood volume always decreased [from an average of 0.12 to 0.09 ml blood/ml lung (P less than 0.05)] after cardiac output was lowered by hemorrhage in a separate set of animals. Total EVLW (by thermodye indicator dilution) did not change. Likewise, regional EVLW remained constant in areas below the left atrium but decreased in areas above the left atrium. We conclude that PET measurements are accurate, noninvasive, and reproducible and that regional changes may be detected even when measurements of total EVLW by other methods may fail to change significantly.

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