The Causative Agent in Atrial Receptor Diuresis in the dog is a Low Molecular Weight, Lipophilic and Weakly Acidic Substance

1985 ◽  
Vol 68 (2) ◽  
pp. 243-246 ◽  
Author(s):  
J. M. Pither ◽  
M. F. Knapp ◽  
H. Gregory ◽  
R. J. Linden
Keyword(s):  
Molecular Weight ◽  
Ethyl Acetate ◽  
Left Atrium ◽  
Antidiuretic Hormone ◽  
Aqueous Phase ◽  
Weight Fraction ◽  
Low Molecular Weight ◽  
Humoral Agent ◽  
Atrial Receptors ◽  
Stimulation Of

1. Stimulation of atrial receptors by distension of a balloon in the left atrium of anaesthetized dogs results in a reflex diuresis mediated by a humoral agent of unknown identity. 2. In previous investigations, a substance was recovered in a low molecular weight fraction from Bio-Gel P-2 (100-1800 daltons) and shown to be related to the reflex diuresis. 3. In this investigation, the active Bio-Gel P-2 fraction was partitioned with ethyl acetate at pH 11.0, with subsequent partition of the aqueous phase with ethyl acetate at pH 7.4; the activity of the humoral agent was soluble in ethyl acetate at pH 7.4. 4. These investigations suggest that the humoral agent is a low molecular weight, lipophilic and weakly acidic substance. 5. The substance is not antidiuretic hormone (ADH) as vasopressin is insoluble in ethyl acetate at pH 7.4.

In Vivo Studies on the Inhibition of Coagulation by Fractionated Heparin and by a Heparin Analogue I. Effects of Heparin Fractions

1981 ◽  
Vol 46 (03) ◽  
pp. 612-616 ◽  
Author(s):  
U Schmitz-Huebner ◽  
L Balleisen ◽  
F Asbeck ◽  
J van de Loo
Keyword(s):  
Molecular Weight ◽  
Day Treatment ◽  
Gel Filtration ◽  
Weight Fraction ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
High Molecular Weight Fraction ◽  
Platelet Factor ◽  
Heparin Fractions

SummaryHigh and low molecular weight heparin fractions obtained by gel filtration chromatography of sodium mucosal heparin were injected subcutaneously into six healthy volunteers and compared with the unfractionated substance in a cross-over trial. Equal doses of 5,000 U were administered twice daily over a period of three days and heparin activity was repeatedly controlled before and 2, 4, 8 hrs after injection by means of the APTT, the anti-Xa clotting test and a chromogenic substrate assay. In addition, the in vivo effect of subcutaneously administered fractionated heparin on platelet function was examined on three of the volunteers. The results show that s.c. injections of the low molecular weight fraction induced markedly higher anti-Xa activity than injections of the other preparations. At the same time, APTT results did not significantly differ. Unfractionated heparin and the high molecular weight fraction enhanced ADP-induced platelet aggregation and collagen-mediated MDA production, while the low molecular weight fraction hardly affected these assays, but potently inhibited thrombin-induced MDA production. All heparin preparations stimulated the release of platelet Factor 4 in plasma. During the three-day treatment periods, no side-effects and no significant changes in the response to heparin injections were detected.

scholarly journals Candidate markers for the detection of hepatocellular carcinoma in low-molecular weight fraction of serum

2007 ◽  
Vol 28 (10) ◽  
pp. 2149-2153 ◽  
Author(s):  
Radoslav Goldman ◽  
Habtom W. Ressom ◽  
Mohamed Abdel-Hamid ◽  
Lenka Goldman ◽  
Antai Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Weight ◽  
Weight Fraction ◽  
Low Molecular Weight

Anti-Inflammatory Activity in the Low Molecular Weight Fraction of Commercial Human Serum Albumin (LMWF5A)

2015 ◽  
Vol 37 (1) ◽  
pp. 55-67 ◽  
Author(s):  
Gregory W. Thomas ◽  
Leonard T. Rael ◽  
Charles W. Mains ◽  
Denetta Slone ◽  
Matthew M. Carrick ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Weight Fraction ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

Characterization of Sol and Gel in Hevea Natural Rubber

1997 ◽  
Vol 70 (5) ◽  
pp. 707-713 ◽  
Author(s):  
Jitladda Tangpakdee ◽  
Yasukuki Tanaka
Keyword(s):  
Molecular Weight ◽  
Weight Fraction ◽  
Toluene Solution ◽  
Low Molecular Weight ◽  
Branch Points ◽  
Gel Content ◽  
High Ammonia ◽  
Linear Molecules ◽  
Cis And Trans

Abstract The gel content of rubber from high-ammonia latex (HA-latex) decreased significantly after deproteinization with proteolytic enzyme. The addition of 1–2% ethanol in toluene solution reduced the gel content of rubbers from HA-latex, deproteinized HA-latex (HA-DP) and pale crepe. Transesterification of the rubber in toluene solution with sodium methoxide dissolved the gel fraction. The gel fractions solubilized after transesterification showed molecular weight distribution rich in low molecular-weight fraction. The Huggins k′ constant of the fractionated rubbers from solubilized-gels was in the range of 0.42–0.45, lower than that of the fractionated HA-DP of 0.5–0.8. This indicates that all the branch-points were decomposed by transesterification to form linear molecules. The Mn values of rubber chains assembling the gel was 5.5−8.3×105 by 13C-NMR measurements of the ratio between cis- and trans-isoprene units, which were comparable to the molecular weight between crosslinks, Mc, of 7−11×105 by swelling measurements. These findings suggest that the branching and crosslinks are composed of two types of branch-points, i. e. one by association or aggregation of proteins or oligopeptides at the initiating end and the other by ester linkages including phosphoric ester at the terminal end.

scholarly journals Antitumor Activities of Low Molecular Weight Fraction Derived from the Cultured Fruit Body of Sparassis crispa in Tumor-Bearing Mice

2007 ◽  
Vol 54 (9) ◽  
pp. 419-423 ◽  
Author(s):  
Kyosuke Yamamoto ◽  
Yoshihiro Nishikawa ◽  
Takashi Kimura ◽  
Munehiko Dombo ◽  
Nariaki Matsuura ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Fruit Body ◽  
Weight Fraction ◽  
Low Molecular Weight ◽  
Antitumor Activities ◽  
Tumor Bearing ◽  
Sparassis Crispa

Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor

1987 ◽  
Vol 247 (1) ◽  
pp. 187-193 ◽  
Author(s):  
U. Rausch ◽  
G. Adler ◽  
H. Weidenbach ◽  
F. Weidenbach ◽  
D. Rudolff ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Proteinase Inhibitor ◽  
Secretory Process ◽  
Low Molecular Weight ◽  
Stimulation Of
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