The Basal Levels of Active and Inactive Plasma Renin Concentration in Infancy and Childhood

1984 ◽  
Vol 67 (4) ◽  
pp. 383-387 ◽  
Author(s):  
T. Fiselier ◽  
F. Derkx ◽  
L. Monnens ◽  
P. Van Munster ◽  
P. Peer ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Renin Concentration ◽  
Active Renin ◽  
Age Related ◽  
Infancy And Childhood ◽  
Basal Plasma ◽  
Inactive Renin

1. Basal plasma renin activity, active and inactive plasma renin concentration were measured in 89 healthy recumbent children aged between 1 week and 16 years. 2. A significant (P<0.001) age-related decrease for active (r = −0.60), inactive (r = −0.59) and total renin concentration (r = −0.66) was observed. 3. After correction for the influence of age, active renin concentration correlated with plasma renin activity (r = 0.81), but not with inactive renin concentration (r = 0.18). 4. The proportions of active and inactive renin were not related to age, and the overall percentage of inactive renin was 79%.

Effects of aging on human plasma renin: simultaneous multiple assays of enzyme activity and immunoactivity of plasma renin

1989 ◽  
Vol 120 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Jitsuo Higaki ◽  
Ryuichi Morishita ◽  
Toshio Ogihara ◽  
Masaru Nishiura
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Normal Subjects ◽  
The Elderly ◽  
Renin Activity ◽  
Elderly Subjects ◽  
Plasma Renin Concentration ◽  
Active Renin ◽  
Effects Of Aging ◽  
Renin Content

Abstract. The effects of aging on plasma renin in normotensive volunteers were evaluated by conventional indirect RIA of angiotensin I and a newly developed direct RIA. Plasma renin activity and the plasma concentration of active renin measured by radiometric assay with monoclonal antibody were significantly lower in 14 subjects over 60 years than in 15 subjects under 60 years (plasma renin activity: 0.5 ± 0.1 vs 1.7 ± 0.4 nmol · 1−1 · h−1, P< 0.01; plasma active renin: 0.50 ± 0.05 vs 0.87 ± 0.13 pmol/l, P< 0.01, means ± sem), wheres neither the total renin activity nor the total plasma renin concentration measured by the newly developed immunometric assay were different in the two groups. In another study, the plasma renin concentration, total renin concentration and immunoreactive total renin concentration measured by direct RIA with polyclonal antibody were determined in 17 young (<60 years) and 12 elderly (≧60 years) subjects. Plasma renin concentration was significantly lower in the elderly subjects (1.7 ± 0.2 nmol · 1−1 · h−1) than in young subjects (3.4 ± 0.7 nmol · 1−1 · h−1, P< 0.05), but the total renin concentration and immunoreactive total renin concentrations in the two groups were not significantly different. These results indicate that the total renin content of the plasma does not change, whereas the active renin content decreases with age in normal subjects, and suggest that activation of prorenin to active renin may be impaired in elderly subjects.

Influence of right atrial stretch on plasma renin activity in the conscious rat

1987 ◽  
Vol 65 (2) ◽  
pp. 257-259 ◽  
Author(s):  
Susan Kaufman
Keyword(s):  
Plasma Renin Activity ◽  
Superior Vena ◽  
Vena Cava ◽  
Extracellular Fluid ◽  
Plasma Renin ◽  
Renin Activity ◽  
Right Atrial ◽  
Balloon Inflation ◽  
Conscious Rat ◽  
Basal Plasma

Rats were prepared with inflatable balloons at the superior vena cava – right atrium junction. After recovery 1 week later, when blood was taken from conscious, normovolaemic animals plasma renin activity was found not to be influenced by right atrial stretch. Plasma renin activity was then measured in rats in which an extracellular fluid deficit had been produced by peritoneal dialysis against a hyperoncotic, isotonic solution. Although basal plasma renin activity was elevated (6.8 ± 0.9 from 1.5 ± 0.2 ng∙mL∙h, n = 19), no depression was observed in the experimental group after 15 or 90 min of balloon inflation. In rats pretreated with isoprenaline (10 μg/kg body wt.) plasma renin activity was also increased over basal levels, but again balloon inflation caused no reduction in plasma renin activity. It would appear that right atrial stretch has little, if any, influence on renin release in the conscious rat.

scholarly journals Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

2009 ◽  
Vol 55 (5) ◽  
pp. 867-877 ◽  
Author(s):  
Duncan J Campbell ◽  
Juerg Nussberger ◽  
Michael Stowasser ◽  
A H Jan Danser ◽  
Alberto Morganti ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Inhibitor Therapy ◽  
Renin Activity ◽  
Renin Inhibitor ◽  
Blood Samples ◽  
Hypertensive Patients ◽  
Active Renin ◽  
Open Conformation ◽  
Background Measurement

AbstractBackground: Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the plasma renin activity (PRA) assay and the renin immunoassay. The clinical application of renin inhibitor therapy has thrown into focus the differences in information provided by activity assays and immunoassays for renin and prorenin measurement and has drawn attention to the need for precautions to ensure their accurate measurement.Content: Renin activity assays and immunoassays provide related but different information. Whereas activity assays measure only active renin, immunoassays measure both active and inhibited renin. Particular care must be taken in the collection and processing of blood samples and in the performance of these assays to avoid errors in renin measurement. Both activity assays and immunoassays are susceptible to renin overestimation due to prorenin activation. In addition, activity assays performed with peptidase inhibitors may overestimate the degree of inhibition of PRA by renin inhibitor therapy. Moreover, immunoassays may overestimate the reactive increase in plasma renin concentration in response to renin inhibitor therapy, owing to the inhibitor promoting conversion of prorenin to an open conformation that is recognized by renin immunoassays.Conclusions: The successful application of renin assays to patient care requires that the clinician and the clinical chemist understand the information provided by these assays and of the precautions necessary to ensure their accuracy.

Plasma Renin Activity, Active and Inactive Renin Concentrations, and their Responses to β1-Adrenoceptor Blockade with Metoprolol in Hyperthyroidism

1986 ◽  
Vol 18 (09) ◽  
pp. 630-634 ◽  
Author(s):  
T. Baba ◽  
S. Murabayashi ◽  
K. Aoyagi ◽  
M. Kitaoka ◽  
M. Nakazono ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Inactive Renin

Effect of age on plasma aldosterone response to exogenous angiotensin II in normotensive subjects

1980 ◽  
Vol 94 (4) ◽  
pp. 552-558 ◽  
Author(s):  
Ryoyu Takeda ◽  
Shinpei Morimoto ◽  
Kenzo Uchida ◽  
Isamu Miyamori ◽  
Tetsuji Hashiba
Keyword(s):  
Angiotensin Ii ◽  
Plasma Renin Activity ◽  
Sodium Intake ◽  
Plasma Renin ◽  
The Elderly ◽  
Plasma Aldosterone ◽  
Renin Activity ◽  
Middle Aged ◽  
Basal Plasma ◽  
Normotensive Subjects

Abstract. The plasma aldosterone response to angiotensin II (10 ng/kg/min for 30 min, iv) under conditions of varied sodium intake was studied in 10 young subjects (20 to 35 years), 9 middle-aged (41 to 56 years) and 11 elderly (66 to 73 years) normotensive subjects. Basal plasma renin activity, basal plasma level and urinary excretion of aldosterone were significantly lower in the elderly than in the young and middle-aged groups on both 130 and 25 mEq sodium intakes. When sodium intake was reduced to 25 mEq for 3 days, the weight loss was significantly greater in the elderly than in the young and middle-aged groups. No significant differences in blood pressure and serum electrolytes were found between the three groups. Angiotensin II infusion caused significant increases in the mean blood pressure in all the three groups, but to a greater extent in the elderly group. Plasma aldosterone level and its absolute increment, but not its per cent increment, after angiotensin II infusion were significantly lower in the elderly than in the young and middle-aged groups. In combined young, middleaged and elderly subjects, the absolute plasma aldosterone increment correlated positively with basal plasma aldosterone and plasma renin activity levels on a 25 mEq sodium intake, and with plasma renin response to sodium restriction. These results suggest that ageing may cause a lesser plasma aldosterone response to angiotensin II with a decrease in basal plasma aldosterone, in parallel with a decrease in plasma renin activity, under condition of low sodium diet.

Immunoradiometric Assay of Active Renin in Human Plasma: Comparison with Plasma Renin Activity

1987 ◽  
Vol 9 (8-9) ◽  
pp. 1383-1390 ◽  
Author(s):  
P. Dessì-fulgheri ◽  
F. Cocco ◽  
N. Glorioso ◽  
F. Bandiera ◽  
P. Madeddu ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Human Plasma ◽  
Plasma Renin ◽  
Renin Activity ◽  
Immunoradiometric Assay ◽  
Active Renin

The Sympathetic Nervous System and the Renin-Angiotensin System in Borderline Hypertension

1981 ◽  
Vol 60 (1) ◽  
pp. 25-31 ◽  
Author(s):  
J. W. Henquet ◽  
T. Kho ◽  
M. Schols ◽  
H. Thijssen ◽  
K. H. Rahn
Keyword(s):  
Plasma Renin Activity ◽  
Plasma Concentrations ◽  
Renin Angiotensin System ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Catecholamine ◽  
Bicycle Ergometry ◽  
Angiotensin System ◽  
Plasma Renin Concentration ◽  
Borderline Hypertension

1. Plasma catecholamine levels as well as plasma renin activity and plasma renin concentration were compared in normotensive volunteers and in subjects with borderline hypertension. All subjects were studied at rest and during bicycle ergometry. 2. The two groups of volunteer subjects did not differ in the plasma concentrations of noradrenaline and adrenaline, both at rest and during physical activity. The same was true for plasma renin activity and plasma renin concentration. Furthermore, urinary excretion of noradrenaline, adrenaline and 4-hydroxy-3-methoxymandelic acid was similar in both groups. 3. The results do not support the assumption that there is increased sympathetic activity in subjects with borderline hypertension.

Plasma Renin Activity in Normal Human Pregnancy and in Pregnancy-Associated Hypertension, with Reference to Cryoactivation

1980 ◽  
Vol 59 (1) ◽  
pp. 49-53 ◽  
Author(s):  
E. D. M. Gallery ◽  
G. S. Stokes ◽  
A. Z. Györy ◽  
J. Rowe ◽  
J. Williams
Keyword(s):  
Plasma Renin Activity ◽  
Pregnant Women ◽  
Sodium Intake ◽  
Plasma Renin ◽  
Normal Pregnancy ◽  
Renin Activity ◽  
Central Feature ◽  
Plasma Renin Concentration ◽  
Significant Difference ◽  
In Pregnancy

1. Because hypertension is the central feature of pre-eclampsia, and because plasma renin activity is known to be elevated in normal pregnancy (with conflicting results published for pre-eclampsia), a prospective study of plasma renin activity was conducted in pregnancy, under conditions of a fixed sodium intake, in 178 initially normotensive volunteer subjects. Thirty of these women developed pregnancy-associated hypertension (pre-eclampsia) in the third trimester. 2. There was a significant elevation of plasma renin activity from the published values for non-pregnant women, throughout gestation in normotensive women. There was no significant difference, at any stage of gestation, between the values for normal women and those who developed pregnancy-associated hypertension. 3. The extent of cryoactivation of renin, produced by usual collection procedures, was investigated in a subgroup of the total population. It was highly significant and quite variable, but was similar in those who developed pregnancy-associated hypertension and in normal pregnant women. The mean increase in plasma renin concentration in maximally cryoactivated samples was 16-fold. 4. Neither measurement of peripheral plasma renin activity nor of cryoactivatable plasma renin concentration is of value in distinguishing between normal pregnant women and those destined for, or with pregnancy-associated, hypertension.

scholarly journals Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass

2004 ◽  
Vol 150 (4) ◽  
pp. 517-523 ◽  
Author(s):  
N Unger ◽  
I Lopez Schmidt ◽  
C Pitt ◽  
MK Walz ◽  
T Philipp ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Screening Method ◽  
Plasma Renin ◽  
Renin Activity ◽  
Primary Hyperaldosteronism ◽  
Receiver Operating Curve ◽  
Adrenal Tumors ◽  
Plasma Aldosterone Concentration ◽  
Active Renin ◽  
Design And Methods

OBJECTIVE: Plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio is an established screening test for primary hyperaldosteronism. Due to the increased recognition of adrenal incidentalomas, reliable parameters are required. Determination of active renin concentration (ARC) in contrast to PRA offers advantages with regard to processing and standardization. The present study compared PRA and ARC under random conditions to establish thresholds for the diagnosis of primary hyperaldosteronism. DESIGN AND METHODS: Fifty patients with various adrenal tumors, including ten patients with aldosterone-secreting adrenal adenomas, as well as ten hypertensive patients and 23 normotensive volunteers were studied. PAC and PRA were measured by radioimmunoassay. ARC was determined by an immunoluminometric assay. RESULTS: Receiver operating curve (ROC) analysis suggested a PAC to ARC ratio threshold of 90 ((ng/l)/(ng/l)) (sensitivity 100%, specificity 98.6%) and a ratio threshold of 62 by additional consideration of PAC > or =200 ng/l (sensitivity 100%, specificity 100%) for the diagnosis of aldosterone-secreting adrenal adenomas. CONCLUSIONS: A PAC to ARC ratio of > or =62 in patients with PAC levels > or =200 ng/l is a reliable screening method for primary hyperaldosteronism in patients with an aldosterone-producing adenoma under random conditions. Because of its advantages with regard to probe processing and its independence from endogenous angiotensinogen levels, ARC may be preferred to PRA.

Sign in / Sign up

Export Citation Format

Share Document