Reduced Brain Na+,K+-Atpase Activity During Acute Hepatic Failure in the Rat: a Possible Cause of Encephalopathy and Cerebral Oedema

1984 ◽  
Vol 66 (6) ◽  
pp. 62P.1-62P ◽  
Author(s):  
R.J. Ede ◽  
C.D. Gove ◽  
Roger Williams
Keyword(s):  
Atpase Activity ◽  
Hepatic Failure ◽  
Cerebral Oedema ◽  
Acute Hepatic Failure ◽  
Possible Cause

Reduced brain Na+,K+-ATPase activity in rats with galactosamine-induced hepatic failure: relationship to encephalopathy and cerebral oedema

1987 ◽  
Vol 72 (3) ◽  
pp. 365-371 ◽  
Author(s):  
Roland J. Ede ◽  
Christopher D. Gove ◽  
Robin D. Hughes ◽  
William Marshall ◽  
Roger Williams
Keyword(s):  
Atpase Activity ◽  
Rat Brain ◽  
Hepatic Failure ◽  
Cerebral Oedema ◽  
Toxic Substance ◽  
Clear Correlation ◽  
Sodium Efflux ◽  
Normal Rat

1. Previously we have shown that sera from patients with fulminant hepatic failure (FHF) will inhibit partially purified rat brain Na+,K+-ATPase and sodium efflux from human leucocytes in vitro. Similar inhibition may be involved in the pathogenesis of encephalopathy and cerebral oedema in these patients. 2. In the present study we have attempted to establish whether the activity of brain Na+,K+-ATPase is decreased in vivo in rats with d-galactosamine induced hepatic failure using homogenates of snap-frozen brains. 3. Na+,K+-ATPase activity was significantly reduced in the forebrain region at the stage of mild encephalopathy (43 h after injection), while at the deeper stage of coma (43–53 h after injection) enzyme activity was further reduced in the forebrain region and was also significantly reduced in the hindbrain region. Ouabain insensitive ATPase activity was not significantly altered at any time. 4. While a significant increase in the water content (0.5%) of the hindbrain region was found 43 h after galactosamine, there was no clear correlation between the development of cerebral oedema and the reduction of Na+,K+-ATPase activity. 5. The activity of partially purified normal rat brain Na+,K+-ATPase was 15% lower when incubated with sera from rats in the deep stage of coma compared with control sera. 6. These data support other evidence that the reduction in brain Na+,K+-ATPase is likely to be due to toxic substance circulating in serum which have been shown to inhibit this enzyme in vitro and to cause coma when administered to normal animals.

Applying the Principles of Bridging Therapy at Concomitant Acute Hepatic Failure

2016 ◽  
Vol 0 (3.74) ◽  
pp. 112
Author(s):  
I.A. Kuchinskaya ◽  
M.V. Bondar ◽  
D.B. Areshnikov ◽  
S.S. Shapoval ◽  
R.D. Dobush
Keyword(s):  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Bridging Therapy

scholarly journals Treatment of acute hepatic failure and encephalopathy with extracorporeal ex vivo pig-liver perfusion in the critical care unit

Critical Care ◽  
10.1186/cc560 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P187
Author(s):  
MC DaSilva ◽  
M Gupta ◽  
MJ Holman ◽  
HG Yang ◽  
RL Conter ◽  
...  
Keyword(s):  
Critical Care ◽  
Hepatic Failure ◽  
Critical Care Unit ◽  
Ex Vivo ◽  
Liver Perfusion ◽  
Acute Hepatic Failure ◽  
Pig Liver

Acute Hepatic Failure in Swine: Hepatectomy Versus Vascular Occlusion

2004 ◽  
Vol 17 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Nils R. Frühauf ◽  
Karl J. Oldhafer ◽  
Stephanie Westermann ◽  
Georgios C. Sotiropoulos ◽  
Gernot M. Kaiser
Keyword(s):  
Hepatic Failure ◽  
Vascular Occlusion ◽  
Acute Hepatic Failure

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

scholarly journals Fatal neurological complication after liver transplantation in acute hepatic failure patient with hepatic encephalopathy

2018 ◽  
Vol 33 (1) ◽  
pp. 96
Author(s):  
Joo-Yun Kim ◽  
Hyun-Su Ri ◽  
Ji-Uk Yoon ◽  
Eun-Ji Choi ◽  
Hye-Jin Kim ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatic Encephalopathy ◽  
Hepatic Failure ◽  
Neurological Complication ◽  
Acute Hepatic Failure
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