Differential Effects of Non-Steroidal Anti-Inflammatory Drugs on Renal Function in the Elderly

1983 ◽  
Vol 65 (3) ◽  
pp. 58P-59P
Author(s):  
W.J.C. Currie ◽  
S.G. Mann ◽  
M.J. Vandenburg
Keyword(s):  
Renal Function ◽  
The Elderly ◽  
Differential Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effects of Nonsteroidal Anti-Inflammatory Drugs on Renal Function in the Elderly

1983 ◽  
Vol 129 (5) ◽  
pp. 1081-1081
Author(s):  
R.B. Stewart ◽  
W.E. Hale ◽  
R.G. Marks
Keyword(s):  
Renal Function ◽  
The Elderly ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effects of Nonsteroidal Anti-inflammatory Drugs on Renal Function in the Elderly

1982 ◽  
Vol 75 (7) ◽  
pp. 824-826 ◽  
Author(s):  
RONALD B. STEWART ◽  
WILLIAM E. HALE ◽  
RONALD G. MARKS
Keyword(s):  
Renal Function ◽  
The Elderly ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Differential effects of non-steroidal anti-inflammatory drugs on seizures produced by pilocarpine in rats

1988 ◽  
Vol 462 (2) ◽  
pp. 275-285 ◽  
Author(s):  
C. Ikonomidou-Turski ◽  
E.A. Cavalheiro ◽  
L. Turski ◽  
Z.A. Bortolotto ◽  
Z. Kleinrok ◽  
...  
Keyword(s):  
Differential Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs in the elderly. Agreement with safe prescription recommendations according to cardiovascular and gastrointestinal risks

2021 ◽  
Vol 17 (9) ◽  
pp. 499-503
Author(s):  
David Vega-Morales ◽  
Iris Rosa Marisol Pérez-Luna ◽  
Virginia Alejandra Aguirre-García ◽  
Brenda Roxana Vázquez-Fuentes
Keyword(s):  
The Elderly ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-Steroidal Anti-Inflammatory Drugs: Usage and Co-prescription with Other Potentially Interacting Drugs in Elderly: a Cross-sectional Study

2019 ◽  
Author(s):  
Nuru Abdu ◽  
Samuel Teweldemedhin ◽  
Asmerom Mosazghi ◽  
Luwam Asfaha ◽  
Makda Teshale ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Drug Interactions ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Protective Agents ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Introduction: Globally, non-steroidal anti-inflammatory drugs (NSAIDs) usage in the elderly with chronic pain has been reported as frequent. Though it is fundamental in maintaining their quality of life, the risk of polypharmacy, drug interactions and adverse effects is of paramount importance as the elderly usually require multiple medications for their co-morbidities. If prescriptions are not appropriately monitored and managed, they are likely to expose patients to serious drug interactions and potentially fatal adverse effects. Thus, the objective of the study was to assess the appropriateness of NSAIDs use and incidence of NSAIDs related potential interactions in elderly. Methods: A descriptive cross-sectional study was conducted among elderly out-patients (aged 60 and above) who visited three hospitals in Asmara between August 22 and September 29, 2018. The sampling design was two-stage random sampling and data was collected using a questionnaire, exit interview and by abstracting information from patients’ clinical cards. Descriptive and analytical statistics including chi-square test and logistic regression were employed using SPSS. Results: A total of 285 elderly respondents were enrolled in the study with similar male to female ratio. One in four of all respondents were chronic NSAIDs users, of which 74.6% were not prescribed prophylactic gastro-protective agents (GPAs). About 20% of the elderly were involved in polypharmacy and nearly all of the encountered potential NSAIDs related interactions (n=322) with prescribed drugs were moderate. Diabetes and hypertension were significantly associated with chronic NSAIDs use (OR=3, 95% CI: 1.54, 5.84; OR=9.99, 95% CI: 4.46, 22.38) and incidence of drug interactions (OR=3.95, 95%CI: 1.92, 8.13; OR=3.12, 95%CI: 1.81, 5.33) while diabetes and cardiac problem were significantly associated with incidence of polypharmacy (OR=4.33, 95% CI: 2.36, 7.96; OR=3.56, 95% CI: 1.05, 12.11). Conclusion: Though the overall reflection of prescription pattern of NSAIDs during the study period was almost satisfactory, gastro-protective agents were poorly prescribed as a prophylaxis.

Sign in / Sign up

Export Citation Format

Share Document