The Protective Effect of γ-Glutamyl l-Dopa on the Glycerol Treated Rat Model of Acute Renal Failure

1983 ◽  
Vol 65 (2) ◽  
pp. 159-164 ◽  
Author(s):  
I. F. Casson ◽  
D. A. Clayden ◽  
G. F. Cope ◽  
M. R. Lee
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Rat Model ◽  
Fold Increase ◽  
Plasma Creatinine ◽  
Control Group ◽  
Creatinine Excretion ◽  
Urine Creatinine ◽  
Before And After

1. γ-Glutamyl l-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no γ-glutamyl l-dopa. 2. The plasma creatinine in rats given γ-glutamyl l-dopa and glycerol was significantly lower than in rats receiving glycerol alone. 3. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by γ-glutamyl l-dopa and the natriuresis abolished. 4. γ-Glutamyl l-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. 5. The administration of γ-glutamyl l-dopa reduces the severity of renal failure produced by glycerol.

Relationship Between Level of Heart Type Fatty Acid Binding Protein (Before and after Procedures) with Acute Renal Failure after PCI in Patients Under PCI

2020 ◽  
Vol 20 (1) ◽  
pp. 41-46
Author(s):  
Habib Haybar ◽  
Ahmad R. Assareh ◽  
Mina Mohammadzadeh ◽  
Shahla A. Hovyzian
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Serum Creatinine ◽  
Fatty Acid Binding Protein ◽  
Coronary Intervention ◽  
Good Test ◽  
Fatty Acid Binding ◽  
Percutaneous Coronary ◽  
Before And After ◽  
Specific Factors

Background & Objective: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors by focusing on HFAB-P that can be predictive for AKI after Percutaneous Coronary Intervention (PCI). Methods: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were divided into three groups based on the development of AKI after the procedure: no AKI, severe AKI (doubling of serum creatinine or needing dialysis) and any type of AKI (increased creatinine ≥ 0/3 mg/dl or a 50% increase in the means of 1/5 times serum creatinine). The demographic and clinical characteristics of the patients, the medical history and the results of the HFABP marker, GFR, and creatinine before and after PCI were evaluated for all patients. Results: The progenies showed 6 patients with severe AKI, 17 patients with any type of AKI, and 72 patients without AKI. Diabetes (P = 0.003), hypertension (P = 0.027), gender of patients (P = 0.025) and hospital admission days (P <0.001) were significantly different among the groups. Patients' age and positive troponin were significantly higher in patients with AKI. HFABP was the only factor that had significant changes before and after PCI (P <0.001). The cut-off value of HFABP was 4.69 with 95.6% sensitivity and 84.7% specificity. It has a good negative predictive value of 98.39% which suggests it to be a good test for the AKI prediction. Glomerular Filtration Rate (GFR) and creatinine (Cr) were significantly different after PCI (P <0.001). Conclusion: HFABP can be considered as a predictor for AKI after PCI. Moreover, our study suggests that evaluating several parameters such as Cr and GFR before and after PCI can predict the AKI development after PCI.

Low Creatininuria due to Hyponatremia Is Reversible in Many Patients

Nephron ◽  
2021 ◽  
pp. 1-5
Author(s):  
Guy Decaux
Keyword(s):  
Retrospective Review ◽  
Sodium Excretion ◽  
Biochemical Data ◽  
Creatinine Excretion ◽  
Urine Creatinine ◽  
Chronic Hyponatremia ◽  
Before And After ◽  
Solute Excretion

<b><i>Background:</i></b> Chronic hyponatremia has been reported to be associated with low solute intake and low creatinine excretion (reflecting likely sarcopenia). We wanted to study the effect, on the long term, of correction of hyponatremia on solute and creatinine excretion in chronic SIADH. <b><i>Methods:</i></b> We made a retrospective review of clinical and biochemical data of patients with euvolemic hyponatremia. We analyzed 24-h urine solute and creatinine excretion in volunteers with hyponatremia induced by dDAVP over 4 days, in 12 patients with chronic SIADH (&#x3e;1 month) before and after a few days of SNa correction and in 12 patients (6 women and 6 men) before and after 3 months of SNa correction by a vaptan or urea. <b><i>Results:</i></b> We confirm a low urine creatinine and solute excretion only in patients with chronic hyponatremia (&#x3e;1 month). Correction of SNa (from 127 ± 2.3 mEq/L to 139 ± 2.8 mEq/L) for &#x3e;3 months, in the 12 patients (mean age 58 ± 18), was associated with an increase in 24-h creatinine excretion (from 986 ± 239 to 1,238 ± 220 mg; <i>p</i> &#x3c; 0.02) and in patients treated with a vaptan (<i>n</i> = 5) solute excretion increased from 656 ± 207 mmol/24 h to 960 ± 193 mmol/24 h (<i>p</i> &#x3c; 0.02). Sodium excretion increased also in the 12 patients (from 100 ± 53 mEq/24 h to 169 ± 38 mEq/24 h; <i>p</i> &#x3c; 0.01). <b><i>Conclusion:</i></b> Chronic hyponatremia (&#x3e;1 month) is associated with a decrease in solute output (or intake) and in creatinine excretion. In many patients, these abnormalities are reversible in the long term.

scholarly journals Development of the proteinuria dosage

2021 ◽  
Vol 14 (3) ◽  
pp. 079-081
Author(s):  
Andriamiarimbola Irène Rakotoniaina ◽  
Miora Koloina Ranaivosoa ◽  
Annick Anjatiana Raherinaivo ◽  
Andry Rasamindrakotroka
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Kidney Disease ◽  
Urine Sample ◽  
Protein Detection ◽  
Urine Collection ◽  
Creatinine Ratio ◽  
Review Of The Literature ◽  
Creatinine Excretion ◽  
Albumin Creatinine Ratio

The 24-hour urine proteinuria or albuminuria ratio is still prescribed for protein detection in urine, despite the fact that it has been replaced by the albuminuria or protein/creatininuria ratio. The use of this ratio eliminates the misinterpretation of 24-hour urine proteinuria. The objective of this development is to clarify the importance of the ratio for the search for albumin or protein in the urine. We conducted a review of the literature focusing on different diagnostic recommendations. Indeed, 24-hour urine collection is tedious and prone to many errors. The ratio is therefore a simple, reliable and standardized indicator for assessing proteinuria except in acute renal failure patients. The correlation between these ratios and 24-hour urine has been demonstrated in several studies in various populations and is currently considered to be the most adequate measure for proteinuria quantification despite the variability in creatinine excretion. The Kidney Disease Improving Global Outcomes recommendations therefore suggest the use of the albumin/creatinine ratio and the protein/creatinine ratio on a 1st morning urine sample to test for proteinuria.

Protective effect of heme oxygenase induction in ischemic acute renal failure

2000 ◽  
Vol 28 (3) ◽  
pp. 809-817 ◽  
Author(s):  
Hiroko Shimizu ◽  
Toru Takahashi ◽  
Tsutomu Suzuki ◽  
Akira Yamasaki ◽  
Tadao Fujiwara ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Heme Oxygenase ◽  
Ischemic Acute Renal Failure

scholarly journals Protective effect of KB-R7943, a novel Na+/Ca2+ exchange inhibitor, on ischemic acute renal failure in rats

2000 ◽  
Vol 82 ◽  
pp. 70
Author(s):  
Junji Yamashita ◽  
Tosihiko Kuro ◽  
Makoto Itoh ◽  
Yutaka Kobayashi ◽  
Masanori Takaoka ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Exchange Inhibitor ◽  
Ischemic Acute Renal Failure

scholarly journals Protective Effect of Carbon Monoxide–Releasing Compounds in Ischemia-Induced Acute Renal Failure

2005 ◽  
Vol 16 (4) ◽  
pp. 950-958 ◽  
Author(s):  
Trinity Vera ◽  
Jeffery R. Henegar ◽  
Heather A. Drummond ◽  
John M. Rimoldi ◽  
David E. Stec
Keyword(s):  
Carbon Monoxide ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect
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