The Control of T Lymphocyte Proliferation by Con a Induced Suppressor Cells in Chronic Liver Disease

1983 ◽  
Vol 64 (2) ◽  
pp. 29P-30P ◽  
Author(s):  
M. Arabi ◽  
K. Nouri-Aria ◽  
G. Alexander ◽  
A.L.W.F. Eddleston ◽  
Roger Williams
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Suppressor Cells ◽  
Chronic Liver ◽  
Con A ◽  
T Lymphocyte Proliferation

T lymphocyte sensitization to hbcag and T cell-mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease

Hepatology ◽  
1985 ◽  
Vol 5 (2) ◽  
pp. 192-197 ◽  
Author(s):  
Sandro Vento ◽  
John E. Hegarty ◽  
Alfredo Alberti ◽  
Charles J. O'brien ◽  
Graeme J. M. Alexander ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Liver Disease ◽  
T Lymphocyte ◽  
Chronic Liver ◽  
B Virus ◽  
Lymphocyte Sensitization

scholarly journals The Relationship between Hepatic Myeloid-Derived Suppressor Cells and Clinicopathological Parameters in Patients with Chronic Liver Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zhijia Zhou ◽  
Penghua Lai ◽  
Shaoliang Zhang ◽  
Yujie Wang ◽  
Ning Qu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Clinical Characteristics ◽  
Suppressor Cells ◽  
Chronic Liver ◽  
Clinicopathological Parameters ◽  
Myeloid Derived Suppressor Cells ◽  
Liver Inflammation ◽  
The Difference ◽  
The Relationship

Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy controls to investigate the expression of MDSCs, and the relationships between the expression of hepatic MDSCs and the clinical characteristics were analyzed. We found that the expression of CD11b+CD33+ MDSCs is closely related to chronic liver disease and positively correlated with clinical parameters such as ALT, AST, and globulin. Ultimately, the present study suggests that hepatic CD11b+CD33+ MDSCs are increased in HCC and AIH and positively correlate with the liver stages of hepatitis activity and liver fibrosis stage.

Suppression of Novel Andrographolide Derivatives on Murine Splenic T Lymphocyte Proliferation

2011 ◽  
Vol 393-395 ◽  
pp. 1000-1003 ◽  
Author(s):  
Zhi Wen Jiang ◽  
Ya Nan Wang ◽  
Hai Wei Xu ◽  
Jing Zhao ◽  
Gui Fu Dai ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
T Lymphocyte ◽  
Lymphocyte Proliferation ◽  
Dependent Manner ◽  
Pharmacological Effects ◽  
Con A ◽  
Chinese Herbal ◽  
T Lymphocyte Proliferation ◽  
Dose Dependent ◽  
Derivatives Of

Andrographolide (1) is a primary constituent of Andrographis paniculata (Burm. f.) Nees which is a Chinese herbal medicine possesses extensive pharmacological effects. In this paper, the effect of compound 1 and some 15-alkylidene substituted derivatives of andrographolide (2-13) on murine splenic T lymphocyte proliferation reaction were appraised using MTT assay. The results showed that most of 15-alkylidene substituted andrographolides appraised could exert potent immunosuppressant effects. Especially compound 5, the most potent among all the tested compounds at concentrations with no obvious cytotoxicity, significantly inhibited the proliferation of murine splenic T lymphocytes activated by Con A in a dose-dependent manner (1.56μmol/l-12.50μmol/l), by the most inhibition of 55.8%. Findings implied that suitable 15-alkylidene substituted andrographolides might possess some better pharmacology activity than 1.

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
Sign in / Sign up

Export Citation Format

Share Document