Reversal of Left Ventricular Hypertrophy after Treatment of Hypertension by Atenolol for One Year

1982 ◽  
Vol 63 (s8) ◽  
pp. 367s-369s ◽  
Author(s):  
F. Sau ◽  
A. Cherchi ◽  
C. Seguro
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Essential Hypertension ◽  
Left Ventricle ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Wall Stress ◽  
Left Ventricular ◽  
R Ratio ◽  
Blood Pressures

1. Fifteen patients with essential hypertension, class I, II WHO, nine males and six females, whose mean age was 46 years, were given atenolol, 100 mg a day, for 1 year. 2. After 1 month, compared with control, systolic and diastolic blood pressures, heart rate and cardiac output were reduced, whereas left ventricular end-diastolic dimension and stroke volume were increased and total vascular resistances, wall stress, left ventricular mass and h/diastolic radius (R) ratio were unchanged. 3. After 1 year, compared with control, systolic and diastolic blood pressures, heart rate and cardiac output were still reduced, total vascular resistance and wall stress were unchanged. End-diastolic dimension and stroke volume reverted to previous values; left ventricular mass and h/R ratio were significantly decreased. 4. These results show that left ventricular hypertrophy in essential hypertension can revert after 1 year of treatment with atenolol, at least in relatively young people. Since the left ventricle wall stress was not changed after atenolol, the regression of left ventricle hypertrophy seems prevalently to be related to the decrease of adrenergic activity of the heart.

scholarly journals Hemodynamic Consequence of Different Pacing Modes after Aortic Valve Replacement

2018 ◽  
Vol 21 (2) ◽  
pp. 090
Author(s):  
Arndt H Kiessling
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Aortic Valve ◽  
Left Ventricular Hypertrophy ◽  
Aortic Valve Replacement ◽  
Diastolic Function ◽  
Valve Replacement ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Heart Rates

Objectives: Ventricular pacemaker stimulation may cause deterioration of hemodynamics in patients with left-ventricular hypertrophy following aortic valve replacement. Since the diastolic function is often impaired, it remains unclear which heart rate best optimizes cardiac output. Low heart rates are suggested to treat impaired diastolic function chronically, but it is possible that cardiac output may be augmented by increasing the heart rate in patients with a fixed stroke volume (SV). The aim of this study is the identification of the best pacing mode and heart rate for the surrogate parameter SV and cardiac index(CI) in patients with left ventricular hypertrophy.Methods: Various pacemaker stimulation modes and different heart rates, as well as their influence on hemodynamics, were tested following aortic valve replacement in 48 patients with severe left-ventricular hypertrophy (Intraventricular septum (IVS)>1.5 cm) and aortic stenosis. SV and cardiac output were recorded by pulse curve analysis. Four modes of stimulation (right ventricular pacemaker stimulation (DDDright), left ventricular pacemaker stimulation (DDDleft), biventricular pacemaker stimulation (DDDbi), atrial pacemaker stimulation (AAI)) were documented at five different rates (60, 80, 100, 120, 140 beats/min) and three different postoperative time points (intraoperatively, 3h and 24h postoperatively).Results: The highest CI was found at linear rates between 60 to 140bpm. AAI was the best mode of stimulation in the majority of cases (35%), but in others, either left, right and/or biventricular stimulation was found to be better (15%). SV showed a u-shaped trend with a peak at 100 beats/min.Conclusion: An increase in the heart rate does not lead to a notable drop in SV postoperatively in left-ventricular hypertrophy; hence a rise in cardiac output can be anticipated up to a rate of 100 beats/min. A standardized response in terms of an ideal pacemaker stimulation mode could not be identified.

scholarly journals Left ventricular hypertrophy and renin-angiotensin-aldosterone system: AT1-receptor blockers are in the focus

2013 ◽  
Vol 10 (1) ◽  
pp. 88-96
Author(s):  
A V Barsukov ◽  
D V Glukhovskoy ◽  
M S Talantseva ◽  
Z V Bagaeva ◽  
E V Pronina ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricle ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Renin Angiotensin ◽  
Reasonable Approach ◽  
Receptor Blockers ◽  
Cardio Vascular ◽  
At1 Receptor Blockers

Left ventricular hypertrophy (LVH) is one of the cardio-vascular continuum components, determining the prognosis of patient with essential hypertension (EH). Pathogenesis of LVH has a multifactor character. Important role in development of cardiomyocites hypertrophy, Intracardiac fibrosis, left ventricle cavity dilation belongs to renin-angiotensin-aldosteron system (RAAS). Pharmacologic blockade of RAAS composes the basis of therapy, directed to LVH regress. Application of Telmisartan is considered high-reasonable approach to treatment of EH-patient with LVH.

Effect of 24-hour blood pressure and heart rate variations on left ventricular hypertrophy and dilatation in essential hypertension

1990 ◽  
Vol 119 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Spyridon D. Moulopoulos ◽  
Stamatios F. Stamatelopoulos ◽  
Nikolaos A. Zakopoulos ◽  
Savvas T. Toumanidis ◽  
Serafim N. Nanas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular
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