Blood Viscosity, Glycaemic Control and Retinopathy in Insulin-Dependent Diabetes

1982 ◽  
Vol 63 (2) ◽  
pp. 211-216 ◽  
Author(s):  
P. Y. W. Poon ◽  
T. L. Dornan ◽  
C. Orde-Peckar ◽  
R. Mullins ◽  
A. J. Bron ◽  
...  
Keyword(s):  
Cell Volume ◽  
Blood Viscosity ◽  
Packed Cell Volume ◽  
Cross Sectional Study ◽  
Plasma Viscosity ◽  
Glycosylated Haemoglobin ◽  
Trend Test ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Low Shear

1. In a cross-sectional study, 32 insulin-treated diabetic patients had elevated low shear (27·1 vs 22·1 mPa s, P < 0·05) and high shear blood viscosity (5·4 vs 5·0 mPa s, P < 0·05) when compared with 10 non-diabetic controls. After correction to 45% packed cell volume, the abnormality had a tendency to be greater in patients with proliferative (mean low shear viscosity, 30·8 mPa s) than background (29·2 mPa s) or nil/minimal retinopathy (27·6 mPa s, 0·05 < P < 0·07, permutational trend test). 2. The fibrinogen levels were higher in the diabetic group (P < 0·05) and correlated with the low shear blood viscosity (rs = 0·38, P < 0·05). 3. In a prospective study, 74 insulin-treated diabetic patients with background retinopathy were randomized into two groups. Thirty-six patients were on attempted improved therapy (A group); in these the mean glycosylated haemoglobin (Hb A1c) fell within 1 year (11·6 to 10·1%, P < 0·001). Both the corrected low shear blood and plasma viscosity fell similarly (P < 0·001). The fall was greater than in those patients who were kept on usual therapy (U group) and whose glycosylated haemoglobin did not change significantly (11·7 to 11·4%) over the year. 4. The effect of diabetes on blood viscosity may not be a direct pathological factor, as the same increased viscosity would be produced by a mean increase of 1·7% in packed cell volume, compared with a population range of 14% packed cell volume.

Blood viscosity responses to maximal exercise in endurance-trained and sedentary female subjects

1985 ◽  
Vol 59 (2) ◽  
pp. 348-353 ◽  
Author(s):  
D. G. Martin ◽  
E. W. Ferguson ◽  
S. Wigutoff ◽  
T. Gawne ◽  
E. B. Schoomaker
Keyword(s):  
Blood Viscosity ◽  
Whole Blood ◽  
Cross Sectional Study ◽  
Plasma Viscosity ◽  
Physical Conditioning ◽  
Plasma Protein Concentration ◽  
Cross Sectional ◽  
Whole Blood Viscosity ◽  
Protein Pool ◽  
Female Subjects

To assess whether the rheological properties of blood might be altered by exercise, we measured whole blood viscosity, plasma viscosity, and its components in healthy female subjects before, immediately after, and 1 h after maximal upright exercise using the Bruce graded exercise protocol. Forty-seven female subjects (15 sedentary, 14 who ran 5–15 miles/wk, and 18 who ran greater than 50 miles/wk), ages 18–43 yr, were evaluated. Whole blood viscosity, measured with a cone and plate viscometer, increased an average of 12.6% with exercise. The increase was greater than can be attributed to the observed 8.9% increase in hematocrit alone due to a coincident increase in plasma protein concentration. However, plasma viscosity did not rise to the degree expected, likely due to a disproportionate observed loss of fibrinogen from the protein pool. These changes were independent of conditioning level or aerobic capacity. In this cross-sectional study, there appears to be no adaptive adjustment in females to physical conditioning that results in changes in blood viscosity.

scholarly journals Possible association of stroke with higher whole blood viscosity: study in a high altitude (Cusco 3399 masl)

2021 ◽  
Author(s):  
Charles Huamani Saldaña ◽  
Franklin Miranda- Solis ◽  
Víctor Oré Montalvo ◽  
William Bayona ◽  
Carlos Perez ◽  
...  
Keyword(s):  
High Altitude ◽  
Blood Viscosity ◽  
Direct Methods ◽  
Cross Sectional Study ◽  
Plasma Viscosity ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Viscosity Study ◽  
The Difference ◽  
The City

Background. Risk factors for stroke have been extensively studied, however, few studies have been carried out in high-altitude cities. Objectives. To evaluate the difference in blood viscosity, using direct methods, in stroke patients versus patients without stroke to discover any possible association. Design and setting. A cross-sectional study was carried out in the city of Cusco, Peru (3399 m.a.s.l). Methods: Participants included stroke patients with less than three days of illness and controls without stroke. Viscosity levels were measured in all patients using a cone-plate viscometer. Blood viscosity was evaluated at 10, 20, 30 and 40 revolutions per minute (RPM) because blood is considered a nonNewtonian fluid. Plasma viscosity was evaluated at 100RPM. All viscosity units are expressed as means standard deviations (SD) in centipoises (cP). Results: A total of 204 patients were included (61 cases/143 controls). The mean age was 67.5 (SD:15.9), and 88 (43%) were women. The means of blood viscosity for 10, 20, 30RPM in the stroke cases were 5.85cP (SD:1.21), 5.22cP (SD:1.09), and 4.91cP (SD:1.02), and 4.81cP (SD:1.02) respectively. For the controls were of 5.57cP (SD:1.19), 4.89cP (SD:4.85), 4.63cP (SD:0.97), 4.56cP (SD:0.95), respectively. All measured means were tested with significant differences (p <0.01). Plasma viscosities were 1.43cP (SD:0.17) for the stroke cases and 1.49cP (SD:0.23) for controls (p=0.05). Conclusions: This study found that blood viscosity is 0.3cP higher in stroke patients. This suggests that blood viscosity could play a role in the etiology. The results presented are preliminary and the study is still under development.

scholarly journals The glycosylated haemoglobin A1c and albuminuria in patients with type 2 diabetes in the Republic of Srpska: A cross sectional study

2019 ◽  
Vol 76 (8) ◽  
pp. 802-807
Author(s):  
Ljiljana Stanivuk ◽  
Bosa Mirjanic-Azaric ◽  
Nadja Vasiljevic
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Cross Sectional Study ◽  
Glycosylated Haemoglobin ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Republic ◽  
Roche Diagnostics

Background/Aim. Glycosylated haemoglobin (HbA1c) is currently the gold standard for glucose monitoring in the patients with diabetes. The aim of the present study was to examine the level of success in implementing international guideline targets with regard to glycaemic control in the patients with type 2 diabetes in the Republic of Srpska. This study also aimed to determine the association of albuminuria with the glycaemic control and lipid levels in this patient population. Methods. The participating diabetic patients were those registered in the project titled ??Estimation of the quality of glycoregulation and presence of vascular complications in the persons with diabetes in the Republic of Srpska.? The study was conducted as a cross-sectional study including 1037 patients. HbA1c was determined by a turbidimetric inhibition immunoassay used Roche Diagnostics. Total cholesterol, triglycerides, LDL-C, and HDL-C were determined by reagents from Roche Diagnostics (Roche Diagnostics, Mannheim, Germany) as well as albumin and creatinine in the urine. Results. Mean value for HbA1c was 7.35 ? 1.61% (57 ? 18 mmol/moL). The 49.46% of all participants achieved target values of HbA1c (< 7% or 53 mmol/moL) and 40.30% had albumin to creatinine ratio (ACR) < 30 mg/g. When the patients were divided according to HbA1c (with HbA1c < 7%, 519 patients, and HbA1c ? 7.0%, 510 patients) the ACR values were different between these groups (39.00 vs. 79.50, p < 0.001). We found no significant difference with respect to lipid status between the groups. Conclusion. The patients with type 2 diabetes in the Republic of Srpska, in a large percentage, did not meet targets for glycaemic control. Improvements are necessary in the treatment and maintenance of this disease process to ensure achievement of goals in management of diabetes, which in turn would decrease longstanding complications of type 2 diabetes.

Perception of Therapeutic Education in Diabetic Patients at Tit Melil Health Center

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Mory Sanoh
Keyword(s):  
Well Being ◽  
Cross Sectional Study ◽  
Basic Element ◽  
Therapeutic Education ◽  
Diabetic Patients ◽  
Oral Antidiabetics ◽  
Educational Training ◽  
Cross Sectional ◽  
Type 2 Diabetics

Introduction : A chronic condition like diabetes interferes with an individual's well-being, and if some of their needs are not met because of the disease, their quality of life is reduced. In this context, therapeutic education constitutes a basic element in the management of diabetes.Materials and Methods : A cross-sectional study by self-administered questionnaire and interviews which were carried out with all type 1 and type 2 diabetics, consultants at the level of the Tit Mélil Primary Health Care establishment, in 2019 and who benefited from or not therapeutic education, with or without complications.Result : The study included 50 diabetic patients, surveys show us that type 1 diabetic patients were 13 (26%). And type 2.37 (74%). Regarding the organization of care, 74% of patients say they are under treatment with oral antidiabetics, 10% oral antidiabetics and insulins, 6% insulin therapy and others under diet. Speaking of Food, 76.5% of diabetics know the importance and know what foods to avoid.Conclusion : TVE is possible, it will result in a change in the structure of programs and new educational training for caregivers.

A cross sectional study on assessment of risk of diabetes mellitus using Indian diabetic risk score in a medical college teaching hospital

2020 ◽  
Vol 5 (2) ◽  
pp. 32-40
Author(s):  
Singam Sivasankar Reddy ◽  
Syeda Rahath ◽  
Rakshitha H N ◽  
Godson K Lal ◽  
Swathy S ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Risk ◽  
Risk Score ◽  
Hospital Setting ◽  
College Teaching ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Patient Counselling ◽  
Related Quality

The objective of the study was to evaluate the risk of diabetes mellitus in elderlywith age above 20 years in a hospital setting using Indian Diabetes risk score and to provide patient counselling regarding their life style modifications and health related quality of life among participants with high risk of developing diabetes.A total of 125 non diabetic patients were interviewed with a pre designed selfstructured questionnaire (IDRS). Participants were chosen voluntarily and a written consent was obtained before the administration of the questionnaire from individual patients. In our study we observed that out of 125 patients,males 26[59%]and 18[41%] females were at high risk, males 39[58.2%] and 28[41.8%] females were at moderate risk, males 5[35.7%] and 9[64.3%] females were at low risk of developing diabetes mellitus.

scholarly journals The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects

2021 ◽  
Vol 18 (13) ◽  
pp. 6980
Author(s):  
Kazuko Kotoku ◽  
Ryoma Michishita ◽  
Takuro Matsuda ◽  
Shotaro Kawakami ◽  
Natsumi Morito ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Kidney Function ◽  
Survival Curve ◽  
Cross Sectional Study ◽  
Trend Test ◽  
Healthy Population ◽  
Middle Aged ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Older Subjects

Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group (p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor.

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