Estimates of Calcitonin Secretion Rates in Health, Paget's Disease and Renal Failure

1981 ◽  
Vol 60 (3) ◽  
pp. 10P-11P
Author(s):  
J. A. Kanis ◽  
G. Heynen ◽  
T. Cundy ◽  
S. Gaspar
Keyword(s):  
Renal Failure ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Calcitonin Secretion ◽  
Secretion Rates

scholarly journals Mass versus Activity: Validation of an Immunometric Assay for Bone Alkaline Phosphatase in Serum

1995 ◽  
Vol 32 (4) ◽  
pp. 405-412 ◽  
Author(s):  
C P Price ◽  
C A Mitchell ◽  
J Moriarty ◽  
M Gray ◽  
K Noonan
Keyword(s):  
Renal Failure ◽  
Alkaline Phosphatase ◽  
Reference Range ◽  
Paget’S Disease ◽  
Bone Alkaline Phosphatase ◽  
Paget's Disease ◽  
Cross Reactivity ◽  
Age Group ◽  
Immunometric Assay ◽  
Activity Measurements

A detailed investigation of the performance of an immunometric assay for the quantitation of bone alkaline phosphatase (ALP) in serum showed that precision of this assay was similar to that of lectin precipitation and electrophoretic methods. Relationships for mass and activity measurements of the bone isoform using samples from children and patients with Paget's disease were similar for lectin and electrophoretic methods. Purified liver enzyme showed 100% cross reactivity in the immunometric assay. However, comparison of the slopes between bone ALP mass and total ALP activity using only samples with predominantly liver or bone isoforms showed that the cross reactivity of the liver isoform in serum was 18·3%. Experiments in which increasing amounts of a sample containing 90% of liver isoform adding to a serum sample from a patient with Paget's disease showed a cross reactivity of 16·5%. The reference range for bone ALP mass was 7–28 μg/L for men ( n = 77) and 5–20 μg/L for women ( n = 110) in the age group 20–50 years. In women over 50 years bone ALP was 28% higher. Increased bone ALP mass was also demonstrated in patients with Paget's disease ( n = 59), liver disease ( n = 95), chronic renal failure ( n = 41) and hyperthyroidism ( n = 17).

Paget's Disease of Bone

2006 ◽  
Vol 39 (11) ◽  
pp. 20
Author(s):  
Elizabeth Mechcatie ◽  
Lora T. McGlade
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone
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