Early Changes in Noradrenaline Content of Some Brain Nuclei in Spontaneously Hypertensive Rats

1980 ◽  
Vol 59 (s6) ◽  
pp. 243s-245s ◽  
Author(s):  
Kim Hanh Le Quan-Bui ◽  
Jean-Luc Elghozi ◽  
Marie-Aude Devynck ◽  
Philippe Meyer
Keyword(s):  
High Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Cardiovascular Regulation ◽  
Hypertensive Rats ◽  
Salt Treatment ◽  
Noradrenaline Content ◽  
Brain Nuclei ◽  
Spontaneously Hypertensive ◽  
Hypothalamic Nuclei ◽  
Adrenergic Activity

1. The noradrenaline content of individual brain nuclei was measured by using high-pressure liquid chromatography coupled with electrochemical detection. 2. This study was performed on spontaneously hypertensive rats during the development of hypertension (4 and 12 weeks) and also on deoxycorticosterone-salt hypertensive rats after 1 and 4 weeks of treatment. 3. In young spontaneously hypertensive rats a significant decrease in noradrenaline content was observed in some medullary and hypothalamic nuclei which are involved in cardiovascular regulation. No change was observed after deoxycorticosterone-salt treatment. 4. It is proposed that a change in adrenergic activity, restricted to brain cardiovascular centres, could represent a mechanism triggering spontaneous hypertension.

Adrenergic activity in arteries of spontaneously hypertensive rats

1981 ◽  
Vol 59 (10) ◽  
pp. 1104-1107 ◽  
Author(s):  
Thomas T. Zsotér ◽  
Steve Sirko ◽  
Camille Wolchinsky ◽  
Dezso Kadar ◽  
Laszlo Endrenyi
Keyword(s):  
Column Chromatography ◽  
Spontaneously Hypertensive Rats ◽  
Similar Proportion ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Tail Artery ◽  
Wistar Kyoto Rats ◽  
Adrenergic Activity ◽  
Wistar Kyoto ◽  
Uptake And Release

This study compares the uptake and release of [3H]norepinephrine and residual 3H content in the tail artery of 7- to 9-week-old and 16- to 18-week-old spontaneously hypertensive rats (SHR) and age matched normotensive Wistar Kyoto rats (WKR). The composition of the 3H overflow from the artery, analyzed with column chromatography, revealed similar proportion of norepinephrine and in metabolites, namely normetanephrine, O-methylated deaminated products, dihydroxy-phenylglycol, and dihydroxymandelic acid in SHR and WKR. [3H]Norepinephrine was retained however in greater proportion in vessels of young and older SHR than in WKR.

Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats

Neuroscience ◽  
1997 ◽  
Vol 78 (4) ◽  
pp. 1187-1193 ◽  
Author(s):  
S Zini ◽  
P Masdehors ◽  
Z Lenkei ◽  
M.-C Fournie-Zaluski ◽  
B.P Roques ◽  
...  
Keyword(s):  
Rat Brain ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Brain Nuclei ◽  
Spontaneously Hypertensive ◽  
Aminopeptidase A ◽  
Increased Activity

Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats

1986 ◽  
Vol 379 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Markku Koulu ◽  
Juan M. Saavedra ◽  
Nina Bjelogrlic ◽  
Masami Niwa ◽  
Hans A˚gren ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Raphe Nuclei ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hypothalamic Nuclei ◽  
Serotonin Turnover ◽  
Raphé Nuclei

Role of renin–angiotensin system and oxidative status on the maternal cardiovascular regulation in spontaneously hypertensive rats

2012 ◽  
Vol 25 (4) ◽  
pp. 498-504 ◽  
Author(s):  
Dayane T. Ognibene ◽  
Lenize C.R.M. Carvalho ◽  
Cristiane A. Costa ◽  
Ana Paula M. Rocha ◽  
Roberto S. de Moura ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Renin Angiotensin System ◽  
Cardiovascular Regulation ◽  
Oxidative Status ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Renin Angiotensin
Sign in / Sign up

Export Citation Format

Share Document