Adipose Tissue Lipoprotein Lipase, Very-Low-Density Lipoprotein APO B Kinetics and Adiposity

1980 ◽  
Vol 58 (2) ◽  
pp. 17P-17P ◽  
Author(s):  
P. J. Magill ◽  
A. Nicoll ◽  
J. St Hilaire ◽  
J. D. Brunzell ◽  
N. E. Miller ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Apo B ◽  
Adipose Tissue Lipoprotein Lipase

Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation

2007 ◽  
Vol 35 (3) ◽  
pp. 472-476 ◽  
Author(s):  
F. Karpe ◽  
A.S. Bickerton ◽  
L. Hodson ◽  
B.A. Fielding ◽  
G.D. Tan ◽  
...  
Keyword(s):  
Stable Isotopes ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Lipase Activity ◽  
Remnant Lipoproteins ◽  
Triacylglycerol Content

The triacylglycerol content of chylomicrons and VLDL (very-low-density lipoprotein) compete for the same lipolytic pathway in the capillary beds. Although chylomicron triacylglycerols appear to be the favoured substrate for lipoprotein lipase, VLDL particles compete in numbers. Methods to quantify the specific triacylglycerol removal from VLDL and chylomicrons may involve endogenous labelling of the triacylglycerol substrate with stable isotopes in combination with arteriovenous blood sampling in humans. Arteriovenous quantification of remnant lipoproteins suggests that adipose tissue with its high lipoprotein lipase activity is a principal site for generation of remnant lipoproteins. Under circumstances of reduced efficiency in the removal of triacylglycerols from lipoproteins, there is accumulation of remnant lipoproteins, which are potentially atherogenic.

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