scholarly journals Urinary Kallikrein in Normotensive Subjects and in Patients with Essential Hypertension

1979 ◽  
Vol 57 (s5) ◽  
pp. 247s-250s ◽  
Author(s):  
H. Zschiedrich ◽  
P. Fleckenstein ◽  
R. Geiger ◽  
E. Fink ◽  
K. Sinterhauf ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Primary Role ◽  
Urinary Kallikrein ◽  
Sodium Potassium ◽  
Urinary Kallikrein Excretion ◽  
Normotensive Subjects

1. Excretion of urinary kallikrein was normal in 13 out of 15 patients with uncomplicated essential hypertension. 2. Frusemide increased urinary kallikrein excretion in normotensive subjects and in patients with essential hypertension. The stimulating effect of frusemide on urinary kallikrein was significantly diminished in patients with essential hypertension. 3. No correlations of urinary kallikrein with sodium, potassium, and aldosterone excretion were found. 4. The results do not support the idea that urinary kallikrein plays a primary role in the pathogenesis of essential hypertension.

Low Urinary Kallikrein Excretion and Elevated Blood Pressure Normalized by Orally Applied Kallikrein in Essential Hypertension

1979 ◽  
Vol 57 (s5) ◽  
pp. 263s-265s ◽  
Author(s):  
A. Overlack ◽  
K. O. Stumpe ◽  
C. Ressel ◽  
F. Krück
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Elevated Blood Pressure ◽  
Urinary Kallikrein ◽  
Elevated Blood ◽  
Kinin System ◽  
Borderline Hypertension ◽  
Low Sodium Diet ◽  
Urinary Kallikrein Excretion ◽  
Normotensive Subjects

1. Urinary kallikrein was measured in 67 patients with essential hypertension and 25 normotensive subjects variously on unrestricted and low sodium diet. Also, the effect of orally applied hog pancreatic kallikrein on elevated blood pressure and kallikrein excretion was evaluated. 2. Urinary kallikrein was reduced in a large subgroup of patients with sustained essential hypertension. 3. With salt restriction, urinary kallikrein rose markedly in normotensive subjects and patients with borderline hypertension but not in those with sustained hypertension. 4. Oral kallikrein normalized reduced kallikrein excretion and lowered elevated blood pressure. 5. The rise in urinary kallikrein with oral kallikrein was due to an increased formation of endogenous enzyme. 6. A defective kallikrein—kinin system may be involved in both the low urinary kallikrein excretion and the hypertension.

The Effect of Aging on Urinary Kallikrein Excretion in Normotensive Subjects and in Patients with Essential Hypertension*

1981 ◽  
Vol 52 (5) ◽  
pp. 1023-1026 ◽  
Author(s):  
TORU NAKA ◽  
TOSHIO OGIHARA ◽  
TAKESHI HATA ◽  
ANNA MARUYAMA ◽  
HIROSHI MIKAMI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Urinary Kallikrein ◽  
Urinary Kallikrein Excretion ◽  
Normotensive Subjects

scholarly journals Effect of Furosemide on Urinary Kallikrein Excretion in Patients with Essential Hypertension

1978 ◽  
Vol 124 (3) ◽  
pp. 197-203 ◽  
Author(s):  
MASAHIDE SEINO ◽  
KEISHI ABE ◽  
NOBUO IROKAWA ◽  
TORU ITO ◽  
MINORU YASUJIMA ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Urinary Kallikrein ◽  
Urinary Kallikrein Excretion

scholarly journals Effect of Spironolactone on Urinary Kallikrein Excretion in Patients with Essential Hypertension and in Primary Aldosteronism

1977 ◽  
Vol 121 (2) ◽  
pp. 111-119 ◽  
Author(s):  
MASAHIDE SEINO ◽  
KEISHI ABE ◽  
YUTAKA SAKURAI ◽  
NOBUO IROKAWA ◽  
MINORU YASUJIMA ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Primary Aldosteronism ◽  
Urinary Kallikrein ◽  
Urinary Kallikrein Excretion

scholarly journals Urinary Kallikrein in Normotensive Subjects and in Patients with Essential Hypertension

1980 ◽  
Vol 2 (3-4) ◽  
pp. 693-708 ◽  
Author(s):  
H. Zschiedrich ◽  
P. Fleckenstein ◽  
R. Geiger ◽  
E. Fink ◽  
K. Sinterhauf ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Urinary Kallikrein ◽  
Normotensive Subjects

Increased Excretion of Kallikrein during Dexamethasone Administrationl in Normal Man on Low and Normal Salt Intake

1983 ◽  
Vol 65 (5) ◽  
pp. 487-490 ◽  
Author(s):  
José M. López ◽  
Eugenio Arteaga ◽  
José A. Rodriguez ◽  
Héctor Croxatto
Keyword(s):  
Salt Intake ◽  
Sodium Intake ◽  
Direct Action ◽  
Urinary Kallikrein ◽  
Kinin System ◽  
Sodium Potassium ◽  
Urinary Kallikrein Excretion ◽  
Renal Kallikrein ◽  
Normal Men ◽  
Kallikrein Kinin System

1. The effect of dexamethasone administration for 3 days on urinary kallikrein excretion was studied in 12 normal men with normal sodium intake (n=6) or low sodium intake (n=6). Urinary excretion of sodium, potassium, 17-hydroxycorticosteroids, aldosterone and water was also measured in all subjects. 2. Dexamethasone administration was associated with a significant increase in urinary kallikrein excretion (F3, 30 = 6.9; P < 0.001) regardless of sodium intake. No significant correlation could be established between the increase in urinary kallikrein excretion and changes in urinary sodium, potassium, 17-hydroxycorticosteroids, aldosterone or water. 3. These results suggest that dexamethasone can exert a direct action on the renal kallikrein-kinin system.

Inhibition of Urinary Kallikrein Excretion by Semi-Purified Renin in the Rat

1979 ◽  
Vol 57 (s5) ◽  
pp. 243s-245s ◽  
Author(s):  
H. R. Croxatto ◽  
G. Silva ◽  
M. Boric
Keyword(s):  
Urinary Excretion ◽  
Considerable Increase ◽  
Rat Kidney ◽  
Renin Activity ◽  
Purification Procedure ◽  
Urinary Kallikrein ◽  
Sodium Potassium ◽  
Water Excretion ◽  
Urinary Kallikrein Excretion ◽  
Natriuretic Effect

1. Rat kidney extracts obtained at successive stages of a purification procedure, which allows the separation of renin and kallikrein, were used in order to investigate their effect upon urinary excretion of kallikrein, sodium, potassium and water in hyperhydrated rats. 2. Only the purified fraction containing renin reduced kallikrein excretion. The decrease of kallikrein coincided with a considerable increase in sodium, potassium and water excretion. 3. The natriuretic effect of renin extract did not depend on the presence of kallikrein. The injection of a mixture of renin and kallikrein attenuated the effect of renin alone, indicating that both enzymes exert antagonistic actions on the excretion of electrolytes and water by the kidneys. 4. A purified fraction of kidney extract containing no kallikrein and only traces of renin activity, had a stimulatory effect on kallikrein, water and elctrolyte excretion.

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