A Within-Patient Comparison of Bethanidine, Methyldopa and Propranolol in the Treatment of Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 567s-570s
Author(s):  
B. N. C. Prichard ◽  
A. J. Boakes ◽  
B. R. Graham
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Treatment Of Hypertension ◽  
Similar Incidence

1. A within-patient comparison showed that bethanidine, methyldopa and propranolol produced similar control of the blood pressure. 2. Unlike bethanidine, propranolol did not produce postural and exercise hypotension; methyldopa was intermediate in effect. 3. Overall side effects were of a similar incidence though there were differences in incidence of particular side effects.

Nutritional management of hypertension: controversies and frontiers Proceedings of one more meeting?

1986 ◽  
Vol 64 (6) ◽  
pp. 770-771
Author(s):  
Frans H. H. Leenen
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Side Effects ◽  
Antihypertensive Therapy ◽  
Mild Hypertension ◽  
Severe Hypertension ◽  
Nutritional Management ◽  
Blood Pressure Elevation ◽  
Cardiovascular Morbidity And Mortality ◽  
Treatment Of Hypertension

In recent years antihypertensive therapy has evolved from treatment for a relatively small number of patients with severe hypertension to treatment for millions of people with mild to severe hypertension. We now treat not only patients at high risk for future cardiovascular morbidity and mortality, of whom nearly all are benefitting from antihypertensive therapy, but also much larger groups of patients each individually at low risk. In this latter group only a small percentage actually benefits from antihypertensive therapy. For example, in the Australian trial in subjects with mild hypertension and no other evidence of cardiovascular disease, only two excess deaths were prevented at the expense of 1000 patient-years of drug treatment (Australian Therapeutic Trial 1980). For most individual members of this group normalizing their mild blood pressure elevation appears to offer no benefit, yet all of them are exposed to antihypertensive therapy and its side effects. When instituting antihypertensive pharmacotherapy in patients with mild hypertension one has to be concerned about these side effects, not just the objective ones (e.g., effects on plasma lipoproteins or glucose which may offset any gains to be obtained by lowering blood pressure), but also subjective ones (e.g., fatigue, impotence) which may markedly affect the quality of life.Nonpharmacologic, in particular nutritional, management of mild hypertension has intuitively major appeal for "lowering blood pressure without side effects." Many studies have evaluated the effects of dietary changes on blood pressure. Several recent symposia have addressed the issue of nutrition and hypertension. Despite this, the report from the first Consensus Development Conference of the Canadian Hypertension Society ("on the management of mild hypertension in Canada") states "Because of conflicting evidence and problems with patient compliance, the conference had difficulty reaching consensus on the effectiveness of salt restriction and, for the obese, of weight reduction in lowering blood pressure" (Logan 1984).This issue of the Canadian Journal of Physiology and Pharmacology contains the proceedings of a workshop "Nutritional Management of Hypertension: Controversies and Frontiers," held in Harrison Hot Springs, British Columbia, September 6–7, 1985. This workshop was organized under the auspices of the Canadian Hypertension Society and made possible by generous financial support from ICI Pharma, Canada (general sponsorship) as well as from the National Institute of Nutrition for the obesity session, and from the Dairy Bureau of Canada for the sodium–calcium session.To define more clearly the controversies and uncertainties, this workshop was organized in a different way than previous meetings dealing with this issue. A clinical scientist working in a particular area was invited to outline the evidence in favour of a given dietary manipulation for the treatment of hypertension, and another one to outline the evidence against. This evaluation would particularly concern evidence regarding "efficacy" and "effectiveness". A discussant then presented an evaluation of the two position papers, followed by a general discussion and a summary by the session chairman. This type of scrutiny of our current knowledge was done for sodium restriction, calcium supplementation, and weight loss. As part of this evaluation two speakers addressed the closely related issues of practical aspects of diet management (e.g. compliance) and the consequences–risks of weight loss in relation to the pathophysiology of obesity.In the last part of the workshop possible future developments in nutrition and hypertension were reviewed, such as "nutrition in the young, early intervention?," vegetarian approach to hypertension, role of dietary fats, and proteins and precursors.The organizing committee very much appreciated that Dr. David Sackett was willing to serve as the scientific chairman of this workshop, to summarize the present "state of the art" on diet modulation in the management of hypertension as well as to propose recommendations for treatment of hypertension in clinical practice and for future research directions.It was a pleasure for me to serve as chairman of the organizing committee. As President of the Canadian Hypertension Society I would like to thank all session chairmen, speakers, discussants, and participants for their enthusiasm and eagerness to explore the topic of nutrition and hypertension. I hope that the scientific information and insight that the proceedings of this workshop offer will convey their commitment.

Advantages of Treatment of Hypertension with Minoxidil

1980 ◽  
Vol 25 (2) ◽  
pp. 99-103
Author(s):  
C. Isles ◽  
R. W. Strachan
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Once Daily ◽  
Hypertensive Patients ◽  
Treatment Of Hypertension ◽  
Highly Effective ◽  
Drug Regimens ◽  
Excellent Control

A detailed study has been made of the five hypertensive patients who received Minoxidil in Dumfries; four have been observed for over a year. Minoxidil was found to be highly effective, free from commonly encountered side effects and capable of achieving excellent control of blood pressure when given once daily. Its use led to simpler drug regimens, improved compliance and significant reduction in the length, or even need, of admission to hospital. A prolonged and clinically useful delay in the recurrence of hypertension following withdrawal of the drug was also observed.

The Treatment of Benign Hypertension with Clonidine

1970 ◽  
Vol 15 (4) ◽  
pp. 137-142 ◽  
Author(s):  
R. J. Kellett ◽  
M. Hamilton
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Pressure Control ◽  
Effective Control ◽  
Comparable Group ◽  
Good Blood Pressure Control ◽  
Methyl Dopa ◽  
Treatment Of Hypertension ◽  
Troublesome Symptom ◽  
Discontinue Therapy

Clonidine (Catapres) is a new drug for the treatment of hypertension which has an uncertain mode of action. Sixty-one patients have been treated with Clonidine for up to 21 months. Side-effects of treatment have been troublesome and in 20 per cent of patients have necessitated discontinuing therapy. Sedation was the most frequent and troublesome side-effect. Dryness of the mouth was a less troublesome symptom. In only 48 per cent of patients continuing Clonidine was good blood pressure control achieved and maintained. In a comparable group of patients treated with Methyl Dopa only 7 per cent had to discontinue therapy because of side-effects of the drug, and effective control was achieved in 70 per cent of the remainder. Clonidine is strikingly devoid of postural and exercise hypotensive effects, and produces a uniform control of blood pressure throughout the day. It has been successfully combined with Methyl Dopa and Bethanidine. Despite its troublesome side-effects, these attributes may make it a satisfactory drug for the treatment of patients in whom uniform control is difficult.

Prazosin and Hydrallazine in the Treatment of Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 617s-619s ◽  
Author(s):  
Priscilla Kincaid-Smith ◽  
A. S. P. Hua ◽  
J. B. Myers ◽  
Ileene Macdonald ◽  
P. Fang
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Diastolic Blood Pressure ◽  
Blocking Agent ◽  
Base Line ◽  
Double Blind ◽  
Supine Diastolic Blood Pressure ◽  
Treatment Of Hypertension ◽  
Blood Pressures

1. Two vasodilators, prazosin and hydrallazine, have been compared in three double-blind cross-over studies designed to test their effect when used in combination with a β-adrenoceptor-blocking agent and a thiazide. 2. Single doses of 3 mg of prazosin or 75 mg of hydrallazine were administered to patients whose blood pressures remained uncontrolled on a thiazide and a β-adrenoceptor-blocking agent. Both agents produced significant falls in systolic and diastolic blood pressure apparent at 1 h. The effects of prazosin persisted for 6–7 h and those of hydrallazine for 4–6 h. Tachycardia was more marked and more prolonged after hydrallazine and continued after the blood pressure had risen to base-line levels or above. 3. In 6 week and 12 week double-blind cross-over studies, mean falls in blood pressure were similar with prazosin and hydrallazine. Similar falls in the supine diastolic blood pressure were achieved with 1 mg of prazosin and 20 mg of hydrallazine, but for a given fall in supine diastolic blood pressure, prazosin produced a significantly lower standing diastolic blood pressure. 4. Severe side effects were more pronounced after hydrallazine, which necessitated withdrawal of seven patients, whereas only one patient on prazosin withdrew from the trial because of side effects.

scholarly journals GAMBARAN KELUHAN DI RONGGA MULUT PADA PENGGUNA OBAT ANTIHIPERTENSI DI POLIKLINIK PENYAKIT DALAM RUMAH SAKIT TINGKAT III ROBERT WOLTER MONGISIDI MANADO

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Priscilia G. J. Tambuwun ◽  
Pieter L. Suling ◽  
Christy N. Mintjelungan
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Oral Cavity ◽  
Antihypertensive Agent ◽  
Antihypertensive Agents ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Treatment Of Hypertension

Abstract: Hypertension is a condition with an increased blood pressure above normal. Treatment of hypertension is proved to be very effective and widely available but some side effects inter alia in the oral cavity cannot be avoided. This study aimed to obtain the oral complaints of hypertensive outpatients at the Internal Department of Robert Wolter Mongisidi Hospital Manado. This was a descriptive cross sectional study. The results showed that of the 30 respondents there were more females (60%) than males (40%). The most frequent age group was 56-60 years (20% males and 26,6% females), and the most frequent antihypertensive agent was amlodipine (80%). The oral complaints were as follows: xerostomia (80%), swollen gums (16,67%), and stomatitis aphtous recurrent (3,33%).Keywords: hypertension, antihypertensive agents, oral complaints.Abstrak: Hipertensi adalah suatu keadaan dimana terjadi peningkatan tekanan darah di atas normal. Pengobatan hipertensi terbukti sangat efektif dan tersedia luas, namun beberapa efek samping akibat penggunaan obat hipertensi antara lain pada rongga mulut tidak dapat dihindari. Penelitian ini bertujuan untuk mengetahui gambaran keluhan di rongga mulut pengguna obat antihipertensi rawat jalan di Poliklinik Penyakit Dalam Rumah Sakit Tingkat III Robert Wolter Mongisidi Manado. Penelitian ini bersifat deskriptif dengan dessain potong lintang. Responden penelitian berjumlah 30 orang. Hasil penelitian memperlihatkan jenis kelamin perempuan (60%) lebih banyak dari laki-laki (40%); usia responden terbanyak 56-60 tahun (46,67%); dan obat antihipertensi yang tersering digunakan ialah amlodipine (80%). Keluhan rongga mulut yang dialami responden ialah xerostomia (80%), gingiva bengkak (16,7%), dan sariawan (3,3%).Kata kunci: hipertensi, obat antihipertensi, keluhan rongga mulut

Trasidrex (A Fixed Combination of Slow Trasicor 160mg and Navidrex 0.25mg) in the Treatment of Hypertension: A Multicentre Clinical Trial in General Practice

1978 ◽  
Vol 6 (6) ◽  
pp. 494-498 ◽  
Author(s):  
A F Ebbutt ◽  
R W Elsdon-Dew ◽  
J E Murphy
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
General Practice ◽  
Side Effects ◽  
Blood Pressure Control ◽  
Fixed Combination ◽  
Pressure Control ◽  
Combination Tablet ◽  
Multicentre Clinical Trial ◽  
Treatment Of Hypertension

Sixty-two patients with hypertension who were treated with a free combination of Slow Trasicor or Trasicor and Navidrex K were transferred to a fixed combination tablet, Trasidrex (slow oxprenolol 160 mg + cyclopenthiazide 0.25 mg). Blood pressure control was marginally improved and there was no increase in side-effects.

Using of urapidil for correction of arterial hypertension in cataract surgery

2021 ◽  
pp. 176-181
Author(s):  
E.A. Bachinin ◽  
◽  
D.Y. Ignatenko ◽  
M.V. Stolyarov ◽  
S.I. Utkin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Comparative Analysis ◽  
Side Effects ◽  
Arterial Hypertension ◽  
Cataract Surgery ◽  
Key Words ◽  
Treatment Of Hypertension ◽  
Group 10 ◽  
Intraoperative Hypertension

Purpose. Comparative analysis of clinical efficacy of urapidil and droperidol for relief of arterial hypertension (AH) during cataract surgery. Material and methods. The study included 30 patients who underwent relief of intraoperative hypertension with urapidil or droperidol in combination with sedation. According to method of treatment of hypertension, 3 groups of patients were distinguished: 1st group – 10 patients whom were injected only with urapidil, 2nd group – 10 patients whom were injected urapidil against the background of sedation; 3rd group – 10 patients whom received droperidol against the background of sedation. Results. We relieved intraoperative rise in blood pressure and avoided complications associated with it, in all 3 groups. Using of urapidil did not cause side effects from cardiovascular, respiratory and nervous systems. The dose of urapidil was reduced when used in conjunction with sedatives. Droperidol has been shown to be effective in patients with cognitive impairment with signs of arousal. Conclusion. The applied methods of relief of intraoperative AH were effective in all patients. Urapidil for correction of AH in outpatients is justified due to its effectiveness and safety. Droperidol for treatment of AH is preferable for patients with unstable psychoemotional status, agitation. Such patients should be monitored in hospital. Key words: urapidil, ebrantil, droperidol, intraoperative arterial hypertension, ophthalmosurgery.

scholarly journals The place of combination of lercanidipine – enalapril in the treatment of hypertension: efficacy, safety, special features

2021 ◽  
pp. 20-23
Author(s):  
O. M. Barna
Keyword(s):  
Blood Pressure ◽  
Side Effects ◽  
Moderate Hypertension ◽  
Evidence Base ◽  
Sufficient Evidence ◽  
Fixed Dose ◽  
Efficacy And Safety ◽  
Adherence To Treatment ◽  
Treatment Of Hypertension ◽  
Dose Combination

In order to improve the effectiveness of antihypertensive treatment, doctors more often prescribe fixed dose combinations of two or three antihypertensive products. In this case, the concomitant effects of these products contribute to better control of blood pressure, improve patient’s adherence to treatment and reduce the risk of side effects. The fixed dose combination of lercanidipine and enalapril is quite new for Ukrainian physicians; however, there is already a sufficient evidence base for the efficacy and safety of such combination therapy. Lecranidipine – enalapril combination reduce systolic and diastolic blood pressure in patients with moderate hypertension without severe side effects. In addition, this combination is effective and safe in patients with comorbidities.

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