Plasma Noradrenaline and Renovascular Hypertension in the Rat

1976 ◽  
Vol 51 (s3) ◽  
pp. 439s-442s
Author(s):  
J. L. Reid ◽  
H. J. Dargie ◽  
S. S. Franklin ◽  
Beverly Fraser
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Renal Artery ◽  
Renovascular Hypertension ◽  
Plasma Noradrenaline ◽  
Hypertensive Rats ◽  
Contralateral Kidney ◽  
Sympathetic Nervous ◽  
Peripheral Sympathetic Nervous System

1. Plasma noradrenaline was measured in groups of rats up to 4 weeks after application of a renal artery clip. 2. When renal artery clipping was accompanied by contralateral nephrectomy (one-kidney model) plasma noradrenaline was significantly higher in hypertensive rats than in sham-operated control rats at 7, 14 and 28 days. 3. Plasma noradrenaline was not altered at any time examined in the two-kidney model (unilateral clip and contralateral kidney left in situ). 4. Neurogenic mechanisms mediated by the peripheral sympathetic nervous system appear to participate in the development of one-kidney renovascular hypertension, but do not play a significant role in the two-kidney model.

scholarly journals SPECULATIONS ОN BLOOD PRESSURE INCREASE MECHANISMS IN RENAL ARTERY CLIPPED WISTAR RATS

2013 ◽  
Vol 19 (3) ◽  
pp. 221-226
Author(s):  
N. V. Kuzmenko ◽  
M. G. Pliss ◽  
N. S. Rubanova ◽  
V. A. Tsyrlin
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Renal Artery ◽  
Renovascular Hypertension ◽  
Wistar Rats ◽  
Renal Denervation ◽  
Renal Nerves ◽  
Blood Pressure Elevation ◽  
Sympathetic Nervous

Objective.To examine the mechanisms underlying the activation of the sympathetic nervous system and blood pressure elevation in vasorenal hypertension in the male Wistar rats weighing 250–300 g.Design and methods.We observed the development of renovascular hypertension, beat-to-beat interval and heart rate variability in animals with intact renal nerves and denervated ischemic kidney for 8 weeks after renal artery clamping. Eight weeks later after renal artery clamping in hypertensive rats with denervated ischemic kidney, both-sided renal denervation was performed, and blood pressure was monitored for 6 weeks.Results.Although the ischemic kidney denervation reduces the activity of the sympathetic nervous system, it does not prevent renovascular hypertension development. However, both-sided renal denervation leads to the normalization of blood pressure in the rats with stable renovascular hypertension.Conclusion.We suggest that increased afferent fl ow from structural formations of the ischemic kidney plays an important role for the increased sympathetic nervous system activity.

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