Delayed Onset and Reduced Severity of Adrenal-Compression Hypertension in Rats Treated with Digitoxin

1976 ◽  
Vol 51 (s3) ◽  
pp. 159s-162s
Author(s):  
C. E. Hall ◽  
S. Ayachi ◽  
O. Hall
Keyword(s):  
Sodium Chloride ◽  
Cardiac Hypertrophy ◽  
Adrenal Glands ◽  
Severe Hypertension ◽  
Unilateral Nephrectomy ◽  
High Sodium ◽  
Delayed Onset ◽  
Sodium Chloride Intake

1. Bilateral compression of adrenal glands combined with unilateral nephrectomy and followed by imposition of a high sodium chloride intake caused severe hypertension in all rats, accompanied by enlargement of the heart, kidneys and adrenal glands, atrophy of the thymus and severe nephrosclerosis. 2. Digitoxin treatment delayed the onset, reduced the incidence and ameliorated the magnitude of the hypertensive response in such rats; it also reduced the degree of cardiac hypertrophy, the severity of nephrosclerosis and completely prevented enlargement of the adrenals and kidneys or atrophy of the thymus.

EFFECT OF SODIUM CHLORIDE INTAKE AND MINERALOCORTICOID LEVEL ON THE GRANULARITY OF JUXTAGLOMERULAR CELLS

1958 ◽  
Vol 17 (3) ◽  
pp. 261-264 ◽  
Author(s):  
M. L. WIEDMAN ◽  
F. W. DUNIHUE ◽  
W. VAN B. ROBERTSON
Keyword(s):  
Sodium Chloride ◽  
Sodium Intake ◽  
Granular Cell ◽  
Juxtaglomerular Apparatus ◽  
High Sodium ◽  
Low Sodium ◽  
Similar Series ◽  
Adrenal Response ◽  
Reported Data ◽  
Sodium Chloride Intake

SUMMARY The effect of combinations of normal, low and high sodium chloride intake with normal, low and high mineralocorticoid level on granularity of cells in the juxtaglomerular apparatus has been studied in the rat. The results have been compared with previously reported data from a similar series in the cat. With one exception, low sodium intake by normal rats, the granular cell index in both rat and cat was inversely related to the mineralocorticoid level and unrelated to the sodium intake. Data are presented which suggest that this exception is only apparent and may be explained on the basis of a different adrenal response by the rat.

scholarly journals High sodium chloride intake exacerbates immobilisation induced bone loss

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Petra Frings ◽  
Natalie Baecker ◽  
Martina Heer
Keyword(s):  
Sodium Chloride ◽  
Bone Loss ◽  
High Sodium ◽  
Sodium Chloride Intake

Soybean proteins counteract heart remodeling in wistar rats fed a high sodium chloride diet

2019 ◽  
Vol 23 (6) ◽  
pp. 92-99
Author(s):  
I. G. Kayukov ◽  
O. N. Beresneva ◽  
M. M. Parastaeva ◽  
G. T. Ivanova ◽  
A. N. Kulikov ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
Cardiac Remodeling ◽  
Wistar Rats ◽  
Salt Intake ◽  
Left Ventricular ◽  
High Salt ◽  
Soy Proteins ◽  
High Sodium ◽  
Heart Remodeling

BACKGROUND. Increased salt intake is associated with a number of cardiovascular events, including increased blood pressure (BP) and the development of left ventricular hypertrophy (LVH). However, there is much evidence that a high content of sodium chloride in the diet does not always lead to an increase in BP, but almost inevitably causes cardiac remodeling, in particular, LVH. Many aspects of myocardial remodeling induced by high sodium content in the food have not been studied enough. THE AIM of the study was to trace the echocardiographic changes in Wistar rats fed the high salt ration and the high salt ration supplemented with soy proteins.MATERIAL AND METHODS. Echocardiography and BP measurements were performed on male Wistar rats, divided into three groups. The first (control; n = 8) included rats that received standard laboratory feed (20.16 % animal protein and 0.34 % NaCl); the second (n = 10) – animals that received standard feed and 8 % NaCl (high salt ration). The third group (n = 10) consisted of rats who consumed a low-protein diet containing 10 % soy protein isolate (SUPRO 760) and 8 % NaCl. The follow-up period was 2 and 4 months.THE RESULTS of the study showed that: (1) the intake of a large amount of salt with a diet does not necessarily lead to the formation of arterial hypertension; (2) despite the absence of a distinct increase in BP, under these conditions signs of cardiac remodeling, in particular, LVH, appear rather quickly; (3) supplementing a high-salt diet with soy isolates counteracts the development of LVH.CONCLUSION. High salt intake with food can cause heart remodeling, regardless of blood pressure, while soy proteins can counteract this process.

Effect of Prolonged High Sodium Chloride Ingestion and Withdrawal upon Blood Pressure of Dogs.

1951 ◽  
Vol 77 (3) ◽  
pp. 379-382 ◽  
Author(s):  
C. M. Wilhelmj ◽  
E. B. Waldmann ◽  
T. F. McGuire
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
High Sodium

scholarly journals Stabilization of the Serum Lithium Concentration by Regulation of Sodium Chloride Intake: Case Report

2016 ◽  
Vol 136 (3) ◽  
pp. 517-521 ◽  
Author(s):  
Takashi Tomita ◽  
Hidekazu Goto ◽  
Kenji Sumiya ◽  
Tadashi Yoshida ◽  
Katsuya Tanaka ◽  
...  
Keyword(s):  
Case Report ◽  
Sodium Chloride ◽  
Lithium Concentration ◽  
Serum Lithium Concentration ◽  
Sodium Chloride Intake

TURBIDITY OF SUSPENSIONS AND MORPHOLOGY OF RED HALOPHILIC BACTERIA AS INFLUENCED BY SODIUM CHLORIDE CONCENTRATION

1960 ◽  
Vol 6 (5) ◽  
pp. 535-543 ◽  
Author(s):  
Dinah Abram ◽  
N. E. Gibbons
Keyword(s):  
Sodium Chloride ◽  
Salt Concentration ◽  
Morphological Changes ◽  
Halophilic Bacteria ◽  
Chloride Concentration ◽  
Chloride Content ◽  
Wall Structure ◽  
Abrupt Decrease ◽  
High Sodium ◽  
Rigid Cell Wall

The optical densities of suspensions of cells of Halobacterium cutirubrum, H. halobium, or H. salinarium, grown in media containing 4.5 M sodium chloride, increase as the salt concentration of the suspending medium decreases, until a maximum is reached at about 2 M; below this concentration there is an abrupt decrease in optical density. The cells are rod shaped in 4.5 M salt and change, as the salt concentration decreases, through irregular transition forms to spheres; equal numbers of transition forms and spheres are present at the point of maximum turbidity, while spheres predominate at lower salt concentrations. Cells suspended in 3.0 M salt, although slightly swollen, are viable, but viability decreases rapidly with the more drastic changes in morphology at lower salt concentrations. Cells grown in the presence of iron are more resistant to morphological changes but follow the same sequence. Cells "fixed" with formaldehyde, at any point in the sequence, act as osmometers and do not rupture in distilled water although their volume increases 10–14 times. The results indicate that the red halophilic rods require a high sodium chloride content in their growth or suspending medium to maintain a rigid cell wall structure.

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