Haemodynamic Studies in Dogs with Chronic Bile-Duct Ligation

1976 ◽  
Vol 50 (6) ◽  
pp. 533-537 ◽  
Author(s):  
S. M. Shasha ◽  
O. S. Better ◽  
C. Chaimovitz ◽  
J. Doman ◽  
Y. Kishon
Keyword(s):  
Bile Duct ◽  
Bile Duct Ligation ◽  
Venous Pressure ◽  
Peripheral Resistance ◽  
Significant Rise ◽  
Cirrhosis Of The Liver ◽  
Sodium Retention ◽  
Oedema Formation ◽  
Duct Ligation

1. Dogs with bile-duct ligation retain salt and water and form ascites. The present study was undertaken to examine the role of haemodynamic factors in the aetiology of this sodium retention. 2. Haemodynamic studies were performed in five dogs before and 5 weeks after bile-duct ligation. 3. After the operation there was an insignificant fall in mean arterial pressure, a significant rise in mean cardiac index and a significant fall in mean total peripheral resistance. 4. It is concluded that heart failure is not a factor in renal sodium retention of the dog with bile-duct ligation, since the central venous pressure was not elevated. 5. The haemodynamic pattern and the tendency to salt retention in the dog with chronic bile-duct ligation closely resemble findings reported in patients with cirrhosis of the liver, and it is suggested that oedema formation in patients with cirrhosis of the liver and dogs with chronic bile-duct ligation shares a common aetiology.

Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-β1, IL-10 and c-Myc

Life Sciences ◽  
2018 ◽  
Vol 211 ◽  
pp. 245-251 ◽  
Author(s):  
Maha H. Sharawy ◽  
Noha Abdel-Rahman ◽  
Nirmeen Megahed ◽  
Mohammed S. El-Awady
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Bile Duct Ligation ◽  
Duct Ligation ◽  
Tgf Β1

scholarly journals Melatonin regulates L-arginine transport and NADPH oxidase in young rats with bile duct ligation: role of protein kinase C

2013 ◽  
Vol 73 (1-4) ◽  
pp. 395-401 ◽  
Author(s):  
You-Lin Tain ◽  
Chih-Cheng Chen ◽  
Chien-Te Lee ◽  
Ying-Hsien Kao ◽  
Jiunn-Ming Sheen ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Bile Duct ◽  
Protein Kinase ◽  
Nadph Oxidase ◽  
Bile Duct Ligation ◽  
Arginine Transport ◽  
Young Rats ◽  
Kinase C ◽  
Duct Ligation

Role of Antidiuretic Hormone in Impaired Urinary Dilution Associated with Chronic Bile-Duct Ligation

1980 ◽  
Vol 58 (6) ◽  
pp. 493-500 ◽  
Author(s):  
O. S. Better ◽  
G. A. Aisenbrey ◽  
T. Berl ◽  
R. J. Anderson ◽  
W. A. Handelman ◽  
...  
Keyword(s):  
Bile Duct ◽  
Antidiuretic Hormone ◽  
Bile Duct Ligation ◽  
Diluting Segment ◽  
Water Excretion ◽  
Duct Ligation ◽  
Normal Mean ◽  
And Function ◽  
Distal Delivery

1. The effect of chronic bile-duct ligation on systemic and renal haemodynamics and on the capacity to dilute the urine was studied in conscious rats. Sham-operated rats served as controls. 2. In the rats with bile-duct ligation, the maximal urinary diluting capacity was impaired, despite an expanded plasma volume, a normal mean arterial pressure and cardiac output, and normal intrarenal determinants of water excretion including distal delivery of fluid and function of the diluting segment. 3. In contrast, maximal urinary dilution capacity was intact in rats with congenital central diabetes insipidus and chronic bile-duct ligation. 4. It is concluded that the defect in urinary dilution in rats with chronic bile-duct ligation is dependent on antidiuretic hormone.

Serial natriuretic response to atrial peptide in preascitic bile duct ligated dogs

1990 ◽  
Vol 68 (11) ◽  
pp. 1396-1400 ◽  
Author(s):  
Elizabeth Maher ◽  
Peter Cernacek ◽  
Mortimer Levy
Keyword(s):  
Bile Duct ◽  
Sodium Excretion ◽  
Bile Duct Ligation ◽  
Control Period ◽  
Sodium Balance ◽  
Sodium Retention ◽  
Time Intervals ◽  
Similar Time ◽  
Duct Ligation ◽  
Time Periods

We determined if nine precirrhotic unanaesthetized dogs with chronic bile duct ligation (CBDL) responded uniformly to atrial natriuretic peptide (ANF) by infusing this peptide sequentially over 8–12 weeks at 175 ng∙kg−1∙min−1 and observing the natriuretic response. ANF was administered every 2 weeks post-CBDL until the 8th week and given again during the cirrhotic phase with ascites present (10–12 weeks post-CBDL). Sodium balance studies were conducted at similar time intervals. During the control period and at weeks, 2, 6, and 8 post-CBDL all dogs responded to ANF with a significant change in sodium excretion (ΔUNaV, 50–240 μequiv./min). At these times, all dogs were in sodium balance. At week 4 and during the ascitic period, heterogeneity of response to ANF was observed. In the former interval, five dogs responded (ΔUNaV, 75–230 μequiv./min) and four did not, while in the latter interval, five dogs responded (ΔUNaV, 50–240 μequiv./min) and three did not (one dog died). In both time periods, there was severe urinary sodium retention (daily UNaV, 11 ± 3 and 2 ± 1 mequiv./day, respectively) while the dogs were ingesting 45 mequiv. Na+/day. The heterogeneity of natriuretic response was not correlated to plasma immunoreactive ANF, renin, or aldosterone levels. Plasma volume was significantly expanded from control during both intervals. We conclude that there is transient sodium retention during the 4th week post-CBDL, and that this period is associated with the heterogeneity of natriuretic response to ANF, despite the absence of ascites or edema.Key words: sodium excretion, cirrhosis, edema.

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