Urinary Cyclic Amp Excretion in Thyroid Disease

1974 ◽  
Vol 47 (5) ◽  
pp. 19P-20P
Author(s):  
D. J. Carter ◽  
D. A. Heath ◽  
R. Hoffenberg
Keyword(s):  
Cyclic Amp ◽  
Thyroid Disease ◽  
Urinary Cyclic Amp

THE EFFECT OF TREATMENT OF HYPERAND HYPOTHYROIDISM ON URINARY EXCRETION OF CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE

1977 ◽  
Vol 84 (3) ◽  
pp. 542-547 ◽  
Author(s):  
D. J. Carter ◽  
D. A. Heath
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Thyroid Disease ◽  
Primary Hypothyroidism ◽  
Euthyroid Status ◽  
Urinary Cyclic Amp ◽  
Effect Of Treatment ◽  
Significant Change ◽  
Hyperthyroid Patients

ABSTRACT The urinary excretion of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) was examined in patients with hyperthyroidism and primary hypothyroidism, before treatment and at least six months later on return to euthyroid status. Urinary cyclic AMP excretion was significantly greater in the hyperthyroid group than in the hypothyroid group both in the basal state (P < 0.01) and the ambulant state (P < 0.001). In ambulant hyperthyroid patients absolute urinary cyclic AMP excretion (μmol/24 h) was significantly greater (P < 0.05) prior to treatment than on return to euthyroid status. In the hypothyroid group no significant change occurred after treatment with 1-thyroxine (P > 0.05). The mechanism of changes in urinary cyclic AMP excretion in thyroid disease are discussed.

Urinary cyclic AMP excretion is increased inMacaca fascicularis andMacaca mulatta compared to humans

1991 ◽  
Vol 23 (3) ◽  
pp. 201-206
Author(s):  
John L. Stock ◽  
James A. Coderre ◽  
James A. Simon
Keyword(s):  
Cyclic Amp ◽  
Urinary Cyclic Amp

Urinary Cyclic AMP in ‘Endogenous' and ‘Neurotic’ Depression

1975 ◽  
Vol 126 (1) ◽  
pp. 49-55 ◽  
Author(s):  
K. Sinanan ◽  
A. M. B. Keatinge ◽  
P. G. S. Beckett ◽  
W. Clayton Love
Keyword(s):  
Cyclic Amp ◽  
Second Messenger ◽  
Adenyl Cyclase ◽  
Induced Responses ◽  
High Concentration ◽  
Cyclic Monophosphate ◽  
Cyclic Amp Phosphodiesterase ◽  
Urinary Cyclic Amp ◽  
The Brain

Since the discovery of adenosine 3'5'-cyclic monophosphate (cyclic AMP) by Sutherland and Rall (1958), the concept has evolved that this nucleotide acts as the second messenger substance for many neurotransmitter and hormone-induced responses (Sutherland, Robison and Butcher, 1968). Cyclic AMP occurs in high concentration in the brain. Cyclic AMP is functionally closely related, and possibly fundamental, to the action of catecholamines and serotonin, both of which have been implicated in the amine hypothesis of depression (Granville-Grossman, 1971). Cyclic AMP is formed from ATP by the action of an enzyme adenyl cyclase, and it is degraded by the enzyme cyclic-AMP-phosphodiesterase (Lancet, Editorial, 1970) both of which occur in brain.

Dissociation between plasma, urine, and renal papillary cyclic AMP content following vasopressin and DDAVP

1979 ◽  
Vol 237 (3) ◽  
pp. F218-F225 ◽  
Author(s):  
M. J. Bia ◽  
S. Dewitt ◽  
J. N. Forrest
Keyword(s):  
Cyclic Amp ◽  
Urine Osmolality ◽  
Brattleboro Rats ◽  
Renal Papilla ◽  
Brattleboro Rat ◽  
Clearance Studies ◽  
Urinary Cyclic Amp ◽  
Stimulation Of

The effects of in vivo physiologic doses of vasopressin and 1-deamino-8-D-arginine vasopressin (DDAVP) on the cyclic AMP content of plasma, urine, and renal papillary tissue were determined in the ADH-deficient Brattleboro rat. During clearance studies, plasma cyclic AMP concentrations and both total and nephrogenous urinary cyclic AMP excretion in vasopressin- and DDAVP-treated rats were similar to the values in time-matched controls. In contrast, in situ renal papillary cyclic AMP content was higher (P less than 0.001) in both vasopressin- (35.7 +/- 3.6 pmol/mg protein) and DDAVP- (29.7 +/- 2.2 pmol/mg protein) treated rats compared to controls (15.1 +/- 1.3 pmol/mg protein). Endogenous stimulation of vasopressin by dehydration in normal rats increased both papillary cyclic AMP content (27.1 +/- 2.7 pmol/mg protein) and urine osmolality, whereas no change in papillary cyclic AMP was observed following dehydration in Brattleboro rats (13.6 +/- 0.8 pmol/mg protein) despite an increase in urine osmolality. The results demonstrate that changes in cyclic AMP following in vivo vasopressin are best demonstrated by measurement of in situ cyclic AMP content of the renal papilla, whereas total urinary cyclic AMP and nephrogenous cyclic AMP are not useful indices of tubular sensitivity to this hormone.

Urinary Adenosine 3’,5′-Cyclic Monophosphate: Effects of Electroconvulsive Therapy

1976 ◽  
Vol 129 (2) ◽  
pp. 173-177 ◽  
Author(s):  
Richard B. Moyes ◽  
Isabel C. A. Moyes
Keyword(s):  
Cyclic Amp ◽  
Electroconvulsive Therapy ◽  
Consistent Pattern ◽  
Cyclic Monophosphate ◽  
Urinary Cyclic Amp

SummarySerial studies of urinary cyclic AMP in in-patients undergoing electroconvulsive therapy (ECT) have been carried out. No consistent pattern of change following ECT could be demonstrated. The results do not support earlier reports of large rises in urinary cAMP directly after administration of ECT.

Renal Acid, Urinary Cyclic AMP, and Hydroxyproline Excretion as Affected by Level of Protein, Sulfur Amino Acid, and Phosphorus Intake

1981 ◽  
Vol 111 (12) ◽  
pp. 2106-2116 ◽  
Author(s):  
Sally A. Schuette ◽  
Maren Hegsted ◽  
Michael B. Zemel ◽  
Hellen M. Linkswiler
Keyword(s):  
Amino Acid ◽  
Cyclic Amp ◽  
Sulfur Amino Acid ◽  
Urinary Cyclic Amp ◽  
Hydroxyproline Excretion ◽  
Phosphorus Intake

scholarly journals Effect of 24,25-dihydroxyvitamin D3 on 1,25-dihydroxyvitamin D3 metabolism in calcium-deficient rats

1988 ◽  
Vol 250 (3) ◽  
pp. 671-677 ◽  
Author(s):  
T Matsumoto ◽  
K Ikeda ◽  
H Yamato ◽  
K Morita ◽  
I Ezawa ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Water Soluble ◽  
Considerable Proportion ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Calcium Diet ◽  
Low Calcium Diet ◽  
Low Calcium ◽  
Urinary Cyclic Amp ◽  
24,25 Dihydroxyvitamin D3

The effect of 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] on 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] metabolism was examined in rats fed on a low-calcium diet. These rats exhibit hypocalcaemia, high urinary cyclic AMP excretion, a markedly elevated serum 1,25(OH)2D concentration and low serum concentrations of both 24,25(OH)2D and 25(OH)D. When the rats are treated orally with 1, 5 or 10 micrograms of 24,25(OH)2D3/100 g every day, there is a dramatic decrease in serum 1,25(OH)2D concentration in a dose-dependent manner concomitant with an increase in serum 24,25(OH)2D concentration. Serum calcium concentration and urinary cyclic AMP excretion are not significantly affected by the 24,25(OH)2D3 treatment, which suggests that parathyroid function is not affected by the 24,25(OH)2D3 treatment. The 25(OH)D3 1 alpha-hydroxylase activity measured in kidney homogenates is markedly elevated in rats on a low-calcium diet but is not affected by any doses of 24,25(OH)2D3. In contrast, recovery of intravenously injected [3H]1,25(OH)2D3 in the serum is decreased in 24,25(OH)2D3-treated rats. Furthermore, when [3H]1,25(OH)2D3 is incubated in vitro with kidney or intestinal homogenates of 24,25(OH)2D3-treated rats there is a decrease in the recovery of radioactivity in the total lipid extract as well as in the 1,25(OH)2D3 fraction along with an increase in the recovery of radioactivity in the water-soluble phase. These results are consistent with the possibility that 24,25(OH)2D3 has an effect on 1,25(OH)2D3 metabolism, namely that of enhancing the degradation of 1,25(OH)2D3. However, because a considerable proportion of the injected 24,25(OH)2D3 is expected to be converted into 1,24,25(OH)3D3 by renal 1 alpha-hydroxylase in 24,25(OH)2D3-treated rats, at least a part of the decrease in serum 1,25(OH)2D concentration may be due to a competitive inhibition by 24,25(OH)2D3 of the synthesis of 1,25(OH)2D3 from 25(OH)D3. Thus the physiological importance of the role of 24,25(OH)2D3 in regulating the serum 1,25(OH)2D concentration as well as the mechanism and metabolic pathway of degradation of 1,25(OH)2D3 remain to be clarified.

BASAL AND HORMONE-INDUCED URINARY CYCLIC AMP IN CHILDREN WITH RENEL DISORDERS

1976 ◽  
Vol 65 (6) ◽  
pp. 739-745 ◽  
Author(s):  
E. MoNN ◽  
J. B. OSNES ◽  
I. ØYE
Keyword(s):  
Cyclic Amp ◽  
Urinary Cyclic Amp
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