Effect of Salmon Calcitonin Treatment on Bone Turnover, Cardiac Output and Oxygen Transport in Patients with Paget's Disease

1974 ◽  
Vol 47 (2) ◽  
pp. 5P-6P
Author(s):  
W. A. Crosbie ◽  
N. J. Y. Woodhouse
Keyword(s):  
Cardiac Output ◽  
Bone Turnover ◽  
Oxygen Transport ◽  
Salmon Calcitonin ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Calcitonin Treatment

Effect of Salmon Calcitonin on Cardiac Output, Oxygen Transport and Bone Turnover in Patients with Paget's Disease

1975 ◽  
Vol 48 (6) ◽  
pp. 537-540 ◽  
Author(s):  
W. A. Crosbie ◽  
S. M. Mohamedally ◽  
N. J. Y. Woodhouse
Keyword(s):  
Cardiac Output ◽  
Pain Relief ◽  
Oxygen Transport ◽  
Salmon Calcitonin ◽  
Bone Pain ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Urinary Hydroxyproline ◽  
The Mean ◽  
Hydroxyproline Excretion

1. Twelve patients with symptomatic Paget's disease were studied before starting treatment with salmon calcitonin (12.5 μg) subcutaneously twice daily. Eleven of them were studied again after 3 months on this therapy. 2. Although pretreatment values for urinary total hydroxyproline excretion and cardiac output were considerably increased in some patients, there was no correlation between these two variables in the group as a whole. 3. Treatment resulted in a striking reduction in disease activity; the mean urinary hydroxyproline decreased 67%. 4. There was, however, no significant fall in cardiac output or change in oxygen transport during treatment. 5. Of the eight patients with bone pain who received treatment, five claimed complete pain relief.

scholarly journals Cardiac output in Paget's disease: response to long-term salmon calcitonin therapy.

BMJ ◽  
1975 ◽  
Vol 4 (5998) ◽  
pp. 686-686 ◽  
Author(s):  
N J Woodhouse ◽  
W A Crosbie ◽  
S M Mohamedally
Keyword(s):  
Cardiac Output ◽  
Salmon Calcitonin ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Disease Response
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