Divided Renal and Peripheral Venous Renin as a Means of Predicting Operative Curability of Renal Hypertension

1973 ◽  
Vol 45 (s1) ◽  
pp. 311s-314s ◽  
Author(s):  
Kikuo Arakawa ◽  
Zenziro Masaki ◽  
Yukio Osada ◽  
Junko Yamada ◽  
Shunro Momose
Keyword(s):  
Plasma Renin Activity ◽  
Similar Pattern ◽  
Renal Vein ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Arterial Stenosis ◽  
Lateral Side ◽  
Corrective Surgery ◽  
Parenchymal Lesion ◽  
Affected Side

1. Eighteen patients with unilateral arterial stenosis or renal parenchymal lesion underwent corrective surgery for hypertension. Operative curability of hypertension was compared with pre-operative plasma renin activity (PRA) determined in three different veins; affected side renal (A), contralateral renal (C), and peripheral veins (P). 2. Those with renal arterial stenosis in whom the PRA in the affected side renal vein was significantly higher (more than 14 ng/ml) than that in both the contra-lateral side and peripheral veins, i.e. those with PRA values showing a pattern of A > C=P were found surgically curable without exception. 3. Patients with unilateral renoparenchymal lesions showed either A, C > P or A = C=P pattern and these were all found not curable. A similar pattern was found in four controls.

Renal Hypertension Due to Hydronephrosis with Normal Plasma Renin Activity

1970 ◽  
Vol 283 (19) ◽  
pp. 1032-1033 ◽  
Author(s):  
John M. Palmer ◽  
Franklin G. Zweiman ◽  
Tatiana A. Assaykeen
Keyword(s):  
Plasma Renin Activity ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity ◽  
Normal Plasma

Peripheral and Renal Vein Plasma Renin Activity in Hypertensive Urological Patients

1982 ◽  
Vol 54 (4) ◽  
pp. 348-353 ◽  
Author(s):  
D. ARMANINI ◽  
F. FALLO ◽  
G. OPOCHER ◽  
M. BOSCARO ◽  
C. SCARONI ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Renal Vein ◽  
Plasma Renin ◽  
Renin Activity

scholarly journals Renal vein plasma renin activity in patients with essential hypertension and renovascular hypertension.

1986 ◽  
Vol 75 (6) ◽  
pp. 728-732
Author(s):  
Ko SATO ◽  
Keishi ABE ◽  
Masahide SEINO ◽  
Minoru YASUJIMA ◽  
Yutaka IMAI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Renovascular Hypertension ◽  
Renal Vein ◽  
Plasma Renin ◽  
Renin Activity

Effects of Sex Hormones on the Renal Pressor System

1971 ◽  
Vol 49 (4) ◽  
pp. 292-301 ◽  
Author(s):  
Alberto Nasjletti ◽  
Masato Matsunaga ◽  
Georges M. C. Masson
Keyword(s):  
Plasma Renin Activity ◽  
Sex Hormones ◽  
Negative Feedback ◽  
Substrate Concentration ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity ◽  
High Substrate Concentration ◽  
High Substrate ◽  
Constant Dose

The effects of sex and sex hormones on angiotensinogen, renin activity, and renin concentration in plasma and on renal renin were investigated in rats. During estrus there was a significant increase in angiotensinogen, which was suppressed by ovariectomy. In males, castration had no effect. Administration of stilbestrol caused a rapid increase in angiotensinogen. Renal renin and plasma renin concentration decreased while plasma renin activity remained near normal levels. Following addition of a constant dose of rat renin, plasma from estrogen-treated rats released angiotensin at a faster rate than normal plasma; this increased reactivity is attributed to the high substrate concentration and not to the lack of an inhibitor, to the presence of an activator, or of a more reactive substrate. These changes were not modified by progesterone or testosterone. Progesterone alone caused a significant increase in renal renin. Estrogens did not elicit hypertension nor modify a preexisting renal hypertension. These observations support the hypothesis that the primary effect of estrogens is an increased angiotensinogen formation, and that the resulting enhancement in plasma reactivity to renin causes an increase in angiotensin which acts as a negative feedback on renin production.

CIRCULATORY RESPONSES, PLASMA RENIN ACTIVITY AND KININOGEN IN RATS WITH RENAL HYPERTENSION

Abstracts ◽  
1978 ◽  
pp. 378
Author(s):  
P. Säynävälammi ◽  
A. Raitanen ◽  
J. Olkoniemi ◽  
T. Pohjolainen ◽  
M.-L. Pyykönen ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Renin Activity

scholarly journals An analysis of errors found in renal vein sampling for plasma renin activity

1977 ◽  
Vol 11 (2) ◽  
pp. 136-138 ◽  
Author(s):  
John S. Horvath ◽  
Claire R. Baxter ◽  
K. Sherbon ◽  
I. Smee ◽  
J. Roche ◽  
...  
Keyword(s):  
Plasma Renin Activity ◽  
Renal Vein ◽  
Plasma Renin ◽  
Renin Activity

A comparison of the development of renal hypertension in male and female rats

1998 ◽  
Vol 95 (4) ◽  
pp. 445-451 ◽  
Author(s):  
Rachel OKUNIEWSKI ◽  
Elizabeth A. DAVIS ◽  
Bevyn JARROTT ◽  
Robert E. WIDDOP
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Renal Hypertension ◽  
Plasma Renin ◽  
Female Rats ◽  
Sham Operation ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Intact Female ◽  
Sprague Dawley Rats

1.The objective of this study was to determine the influence of gender on the development of renal hypertension in Sprague–Dawley rats using the Goldblatt two-kidney, one-clip (2K1C) model. In addition, this study examined the effect of ovariectomy upon the development of hypertension in female rats. 2.At 10 weeks of age, male, intact female and ovariectomized female rats underwent clipping of the right renal artery or sham operation. Tail-cuff plethysmography was used to monitor the systolic blood pressure of all animals for 7 weeks post-clipping or sham operation. Rats were sub-grouped according to whether or not they developed hypertension (systolic blood pressure ⩾ 150 ;mmHg). 3.Within 2 to 3 weeks of clipping, hypertension was induced in only 53% (n = 120) of the intact female 2K1C rats, but in 83% (n = 18) of the male and 78% (n = 18) of the ovariectomized female rats. 4.Seven weeks after right renal artery clipping, plasma renin activity was determined in a subset of each group and was found to be 5–6 fold higher in male (17.29±4.04 ;ng angiotensin I·h-1·ml-1) and ovariectomized female (9.71±1.25 ;ng angiotensin I·h-1·ml-1) hypertensive rats compared with their respective normotensive or sham-operated counterparts (3.39±0.58 ;ng angiotensin I·h-1·ml-1 and 1.60±0.41 ;ng angiotensin I·h-1·ml-1 respectively) (P< 0.05, analysis of variance). In contrast, the plasma renin activity measured in intact female hypertensive rats was not significantly different from that measured in the corresponding 2K1C normotensive or sham-operated groups. 5.These results indicate that the success rate of inducing renal hypertension in Sprague–Dawley rats is higher in males than in intact females. Furthermore, these results suggest that the induction of 2K1C hypertension may be influenced by ovarian hormones.

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