Renal Handling of Calcium, Magnesium, Inorganic Phosphate and Hydrogen Ions during Prolonged Exposure to Elevated Carbon Dioxide Concentrations

1973 ◽  
Vol 45 (6) ◽  
pp. 751-764 ◽  
Author(s):  
S. P. Gray ◽  
J. E. W. Morris ◽  
C. J. Brooks
Keyword(s):  
Urinary Excretion ◽  
Inorganic Phosphate ◽  
Prolonged Exposure ◽  
Serum Levels ◽  
Hydrogen Ions ◽  
Acid Excretion ◽  
Renal Handling ◽  
Carbon Dioxide Concentrations ◽  
Calcium Magnesium ◽  
Urinary Acid

1. Fifteen healthy young men were exposed to an atmosphere of 0–7% CO2 in air for 7 weeks. 2. For 1 week before and during the exposure to CO2, serum calcium, magnesium and inorganic phosphate (Pi) levels were measured at intervals, together with 24 h urinary excretion of these three components, and net urinary acid excretion. 3. The urinary excretion of Ca2+, Mg2+ and Pi fell during exposure to CO2, whereas the serum levels of these components increased. 4. Serum levels of calcium were inversely correlated with urinary Ca2+ excretion both in control conditions and during exposure to CO2 5. An increase in urinary acid excretion in the third to fourth week of exposure to CO2 was associated with an increase in the urinary excretion of Ca2+, but not of Mg2+. 6. It is suggested that there is a difference from the normal in the renal handling of H+ and Ca2+ ions during exposure to CO2 which may lead to a retention of Ca2+ in the tissues.

Magnesiuric and calciuric effects of terbutaline in man

1988 ◽  
Vol 74 (6) ◽  
pp. 595-597 ◽  
Author(s):  
W. J. W. Bos ◽  
D. S. Postma ◽  
J. J. van Doormaal
Keyword(s):  
Calcium Phosphate ◽  
Urinary Excretion ◽  
Healthy Volunteers ◽  
Cardiac Disease ◽  
Serum Levels ◽  
Ionized Calcium ◽  
Short Term ◽  
Cyclic Monophosphate ◽  
Calcium Magnesium ◽  
Calcium And Magnesium

1. The effect of terbutaline infusion over 4 h on serum levels of potassium, ionized calcium, phosphate and magnesium and urinary excretion of potassium, calcium, magnesium and adenosine 3′:5′-cyclic monophosphate was studied in six healthy volunteers. 2. Serum levels of potassium, calcium, phosphate and magnesium decreased. Urinary excretion of potassium decreased, whereas those of calcium, magnesium and adenosine 3′:5′-cyclic monophosphate increased. 3. These results indicate that the hypocalcaemic and hypomagnesaemic effects of terbutaline can, at least partly, be explained by enhanced urinary excretion of calcium and magnesium. This may have important implications for the short-term terbutaline treatment of patients with, for example, cardiac disease.

Effect of Parathyroid Hormone on cAMP and 1,25-Dihydroxyvitamin D Formation and Renal Handling of Phosphate in Vitamin D-Dependent Rickets

PEDIATRICS ◽  
1983 ◽  
Vol 71 (1) ◽  
pp. 59-63
Author(s):  
Dagfinn Aarskog ◽  
Lage Aksnes ◽  
Trond Markestad
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Serum Concentration ◽  
Urinary Excretion ◽  
Serum Levels ◽  
Renal Handling ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Control Subjects

Studies were carried out to compare the effects of parathyroid extract (PTE) on the serum concentration of 1,25-dihydroxyvitamin D (1,25[OH]2D), 24,25-dihydroxyvitamin D (24,25[OH]2D), 25,26-dihydroxy vitamin D (25,26[OH]2D) and cAMP, and the urinary excretion of calcium, phosphorus, and cAMP in two normal adult subjects, and in a girl with vitamin D-dependent rickets. The concentration of 1,25[OH]2D was markedly decreased even when she was receiving a daily dose of 25,000 IU of ergocalciferol. PTE infusion resulted in a prompt and distinct increase in the serum levels and the urinary excretion of cAMP in the patient and control subjects. In the control subjects the serum concentration of 1,25[OH]2D increased after the PTE infusion, whereas there was no response in the patient with vitamin D-dependent rickets. The two other dihydroxylated metabolites of vitamin D showed no consistent response to the PTE infusion in the control subjects or the patient. The patient showed no phosphaturic response to PTE while she was receiving high-dosage ergocalciferol treatment. By contrast, when the patient was re-studied after therapy with lα-hydroxyvitamin D, PTE infusion resulted in an increase in urinary phosphate excretion. These findings might lend support for the notion that 1,25[OH]2D has an effect on tubular phosphate resorption and has a permissive role in the phosphaturic effect of parathyroid hormone. The present findings also confirm that the formation of 1,25[OH]2D is impaired in vitamin D-dependent rickets and indicate that the renal 25-hydroxyvitamin D-lα-hydroxylase is unresponsive to the stimulatory effect of parathyroid hormone in this condition.

Renal Excretion of Bicarbonate and Hydrogen Ions: Effects of Mannitol Diuresis in Normal Man

1972 ◽  
Vol 43 (4) ◽  
pp. 561-567 ◽  
Author(s):  
P. A. Poole-Wilson ◽  
J. Patrick ◽  
G. A. MacGregor ◽  
N. F. Jones
Keyword(s):  
Renal Excretion ◽  
Hydrogen Ion ◽  
Normal Adult ◽  
Hydrogen Ions ◽  
Acid Excretion ◽  
Urinary Ph ◽  
Titratable Acid ◽  
Initial Ph ◽  
Normal Man ◽  
Urinary Acid

1. The pattern of urinary acid excretion during mannitol diuresis was studied in five normal adult subjects. 2. At peak diuresis (osmolal clearance 19·3–27·9 ml/min), the urinary pH approached 6·9 irrespective of the initial pH. 3. Total hydrogen ion excretion fell sharply during mannitol diuresis. Changes in the excretion of ammonium and titratable acid were small and variable, but in each subject bicarbonate excretion increased markedly. 4. Despite previous conflicting published results urinary acid excretion during mannitol diuresis in man resembles that in the dog and is dominated by a bicarbonate diuresis.

scholarly journals THE URINARY EXCRETION OF INORGANIC PHOSPHATE IN FASTING WITH PARTICULAR REFERENCE TO THE EFFECT OF EXERCISE

1932 ◽  
Vol 98 (1) ◽  
pp. 269-279
Author(s):  
Arthur G. Mulder ◽  
Irwin E. Phillips ◽  
Maurice B. Visscher
Keyword(s):  
Urinary Excretion ◽  
Inorganic Phosphate

Effect of prolonged exposure of rats to high carbon dioxide concentrations

1978 ◽  
Vol 86 (3) ◽  
pp. 1149-1151
Author(s):  
P. M. Gramenitskii ◽  
V. A. Galichii ◽  
N. V. Petrova ◽  
N. Yu. Leont'eva
Keyword(s):  
Carbon Dioxide ◽  
Prolonged Exposure ◽  
High Carbon ◽  
Carbon Dioxide Concentrations ◽  
High Carbon Dioxide

scholarly journals 48 Urinary Acid Excretion in the Intact Lamb Fetus

1967 ◽  
Vol 1 (3) ◽  
pp. 212-212
Author(s):  
Fred G Smith ◽  
Richard Bashore
Keyword(s):  
Acid Excretion ◽  
Urinary Acid
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