The Effect of Plasma from Blood Volume Expanded Dogs on Sodium and Potassium Transport of Renal Tubule Fragments

1970 ◽  
Vol 38 (5) ◽  
pp. 34P-34P
Author(s):  
E. M. Clarkson ◽  
L. B. Talner ◽  
H. E. de Wardener
Keyword(s):  
Blood Volume ◽  
Renal Tubule ◽  
Potassium Transport ◽  
Sodium And Potassium

Inhibition of Sodium and Potassium Transport in Separated Renal Tubule Fragments Incubated in Extracts of Urine Obtained from Salt-Loaded Individuals

1972 ◽  
Vol 42 (5) ◽  
pp. 607-617 ◽  
Author(s):  
E. M. Clarkson ◽  
H. E. De Wardener
Keyword(s):  
Sodium Transport ◽  
Renal Tubule ◽  
Gel Filtration ◽  
Oral Intake ◽  
Potassium Transport ◽  
Intracellular Sodium ◽  
Rabbit Kidney ◽  
Kidney Cortex ◽  
Freeze Dried ◽  
Sodium And Potassium

1. Extracts of urine were prepared from salt-depleted and salt-loaded subjects by gel filtration of freeze-dried urine on Sephadex G-50. The extracts were dissolved and adjusted to physiological pH and electrolyte concentration. 2. Separated renal tubule fragments were prepared from rabbit kidney cortex and their intracellular sodium and potassium measured after incubation in the dissolved adjusted extracts. Those concerned with the measurement of intracellular sodium and potassium did not know the identity of the samples. 3. Extracts of urine from salt-loaded subjects inhibited the sodium and potassium transport of the tubules whereas extracts of urine from salt-depleted subjects had no effect. 4. Of ten known hormones that were tested, none had any inhibitory effect on the sodium transport of the tubule fragments. 5. It is concluded that the oral intake of large amounts of salt in normal subjects causes the appearance of an unknown substance in the urine which inhibits sodium transport in separated renal tubule fragments.

The Effect of Plasma from Blood Volume Expanded Dogs on Sodium, Potassium and Pah Transport of Renal Tubule Fragments

1970 ◽  
Vol 38 (6) ◽  
pp. 617-627 ◽  
Author(s):  
E. M. Clarkson ◽  
L. B. Talner ◽  
H. E. de Wardener
Keyword(s):  
Blood Volume ◽  
Volume Expansion ◽  
Renal Tubule ◽  
Sodium Potassium ◽  
Transport Studies ◽  
Blood Volume Expansion ◽  
Before And After ◽  
Control Plasma ◽  
Sodium And Potassium

1. Sodium, potassium and para-amino hippurate (PAH) transport was studied in renal tubule fragments incubated in vitro in plasma taken from dogs before and after their blood volume was expanded with blood with which the dog was in equilibrium. The individuals who carried out the cell transport studies did not know the identity of the plasma samples. 2. Tubule fragments were less able to maintain a gradient of sodium and potassium, or to accumulate PAH when incubated in plasma obtained after blood volume expansion than when they were incubated in control plasma. 3. It is concluded that expansion of the blood volume causes the dog to change the concentration of some unknown circulating substance which influences sodium, potassium and PAH transport in separated tubule fragments. 4. It is proposed that this substance is partly responsible for the rise in urinary excretion of sodium that accompanies blood volume expansion in the intact animal.

Early contributions to the neurochemistry of sodium and potassium transport

1989 ◽  
Vol 14 (3) ◽  
pp. 243-248
Author(s):  
William L. Stahl ◽  
Phillip D. Swanson
Keyword(s):  
Potassium Transport ◽  
Sodium And Potassium

scholarly journals A novel antiporter activity catalyzing sodium and potassium transport from right-side-out vesicles of E. coli

FEBS Letters ◽  
1995 ◽  
Vol 363 (1-2) ◽  
pp. 46-48 ◽  
Author(s):  
Marina L. Verkhovskaya ◽  
Michael I. Verkhovsky ◽  
Mårten Wikström
Keyword(s):  
Potassium Transport ◽  
E Coli ◽  
Sodium And Potassium
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