scholarly journals Effects of the β-agonist, isoprenaline, on the down-regulation, functional responsiveness and trafficking of β2-adrenergic receptors with N-terminal polymorphisms

2012 ◽  
Vol 36 (12) ◽  
pp. 1171-1183 ◽  
Author(s):  
Yulia Koryakina ◽  
Stacie M. Jones ◽  
Lawrence E. Cornett ◽  
Kathryn Seely ◽  
Lisa Brents ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Down Regulation ◽  
Functional Responsiveness

Decreased glucagon binding and glucagon-stimulated lipolysis in adipocytes from streptozotocin-diabetic rats

1989 ◽  
Vol 121 (5) ◽  
pp. 705-713 ◽  
Author(s):  
Nobuyuki Sato ◽  
Minoru Irie ◽  
Hiroshi Kajinuma ◽  
Kazuo Suzuki
Keyword(s):  
Quantitative Analysis ◽  
Cyclic Amp ◽  
Adrenergic Receptors ◽  
Marked Reduction ◽  
Diabetic Rats ◽  
Down Regulation ◽  
Streptozotocin Diabetic Rats ◽  
Β Adrenergic Receptors ◽  
Glucagon Receptors ◽  
The Relationship

Abstract. Adipocytes from streptozotocin-diabetic rats showed a markedly reduced lipolytic response to glucagon concomitant with a 90% or greater decrease in the number of glucagon receptors per cell. In contrast, β-adrenergic receptors assessed by [3H]dihydroalprenolol binding and lipolysis stimulated by isoproterenol, dibutyryl 3′5′-cyclic AMP and 3-isobutyl-1-methylxanthine were reduced by only 10–25% in diabetic rats compared with controls. Furthermore, quantitative analysis of the relationship between the amount of cell-bound glucagon and the hormone-stimulated lipolysis revealed that the function of the remaining 10% of glucagon receptors remained intact in cells from diabetic animals. These findings suggest that the lipolytic cascades, including β-adrenergic receptors, in adipocytes are not greatly impaired by diabetes, and therefore, the unresponsiveness of these cells to glucagon is mostly due to a marked reduction in the number of glucagon receptors, probably as a result of a down-regulation by postprandial hyperglucagonemia.

scholarly journals Tocolytic Therapy with Fenoterol Induces Selective Down-Regulation of β-Adrenergic Receptors in Human Myometrium1

1997 ◽  
Vol 82 (4) ◽  
pp. 1235-1242
Author(s):  
Stefan Engelhardt ◽  
Wolfgang Zieger ◽  
Jan Kassubek ◽  
Martin C. Michel ◽  
Martin J. Lohse ◽  
...  
Keyword(s):  
Adrenergic Receptors ◽  
Down Regulation ◽  
Β Adrenergic Receptors
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