Human PMNs are phagocytosed by dendritic cells and interfere with DCs maturation: a new link between innate and acquired immunity

2010 ◽  
Vol 34 (8) ◽  
pp. S72-S72
Author(s):  
Qi Xu ◽  
Xiumin Ma ◽  
Yuejie Zhu ◽  
Fengsen Li ◽  
Jianbing Ding
Keyword(s):  
Dendritic Cells ◽  
Acquired Immunity ◽  
Human Pmns

Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

10.1038/ni943 ◽  
2003 ◽  
Vol 4 (7) ◽  
pp. 694-701 ◽  
Author(s):  
Kenji Kabashima ◽  
Takahiko Murata ◽  
Hiroyuki Tanaka ◽  
Toshiyuki Matsuoka ◽  
Daiji Sakata ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Thromboxane A2 ◽  
Acquired Immunity

scholarly journals Interaction of Salmonella entericaSerotype Typhimurium with Dendritic Cells Is Defined by Targeting to Compartments Lacking Lysosomal Membrane Glycoproteins

2000 ◽  
Vol 68 (5) ◽  
pp. 2985-2991 ◽  
Author(s):  
Francisco García-Del Portillo ◽  
Heidrun Jungnitz ◽  
Manfred Rohde ◽  
Carlos A. Guzmán
Keyword(s):  
Dendritic Cells ◽  
Salmonella Enterica ◽  
Regulatory System ◽  
Intracellular Survival ◽  
Lysosomal Membrane ◽  
Acquired Immunity ◽  
Pathogenic Microorganisms ◽  
Membrane Glycoproteins ◽  
Two Component ◽  
Dc Line

ABSTRACT Dendritic cells (DCs) play a central role in the generation of acquired immunity to infections by pathogenic microorganisms.Salmonella enterica serotype Typhimurium is known to survive and proliferate intracellularly within macrophages and nonphagocytic cells, but no data exist on how this pathogen interacts with DCs. In this report, we show the capacity of serotype Typhimurium to survive within the established mouse DC line CB1. In contrast to the case for the macrophage model, the compartments of DCs containing serotype Typhimurium are devoid of lysosomal membrane glycoproteins and the PhoPQ two-component regulatory system is not essential for pathogen intracellular survival.

scholarly journals Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10

2006 ◽  
Vol 87 (11) ◽  
pp. 3177-3181 ◽  
Author(s):  
Anna Chan ◽  
Margaret Baird ◽  
Andrew A. Mercer ◽  
Stephen B. Fleming
Keyword(s):  
Dendritic Cells ◽  
Progressive Disease ◽  
Skin Lesions ◽  
Interleukin 10 ◽  
Orf Virus ◽  
Acquired Immunity ◽  
Surface Activation ◽  
Mhc Ii ◽  
And Function ◽  
Human Dendritic Cells

Orf virus (ORFV) is a parapoxvirus that infects sheep, goats and man. In humans, the virus induces acute, pustular skin lesions that can develop into a progressive disease. Humans are susceptible to reinfection with ORFV and rare cases of persistent infection have been reported. ORFV encodes several immunomodulators, including a homologue of interleukin-10 (ORFV IL-10), that may explain these phenomena. The immunosuppressive effects of ORFV IL-10 on immature human dendritic cells (DCs) cultured from blood-derived monocytes (MoDCs) were investigated. MoDCs exposed simultaneously to lipopolysaccharide and ORFV IL-10 showed enhanced ovalbumin–FITC uptake and reduced IL-12 expression, indicating inhibition of maturation. Moreover, ORFV IL-10 inhibited the upregulation of DC cell-surface activation and maturation markers MHC II, CD80, CD83 and CD86 and inhibited the capacity of MoDCs to activate CD4+ T cells in an oxidative mitogenesis assay. These findings suggest that ORFV IL-10 may influence the development of acquired immunity in humans by impairing DC function.

scholarly journals CD40ligand‐expressing dendritic cells induce regression of hepatocellular carcinoma by activating innate and acquired immunity in vivo

Hepatology ◽  
2008 ◽  
Vol 48 (1) ◽  
pp. 157-168 ◽  
Author(s):  
Maria A. Gonzalez‐Carmona ◽  
Veronika Lukacs‐Kornek ◽  
Anne Timmerman ◽  
Sara Shabani ◽  
Miroslaw Kornek ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dendritic Cells ◽  
Acquired Immunity

scholarly journals Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity

2017 ◽  
Vol 25 (6) ◽  
pp. 1294-1304.e6 ◽  
Author(s):  
Marit Westerterp ◽  
Emmanuel L. Gautier ◽  
Anjali Ganda ◽  
Matthew M. Molusky ◽  
Wei Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Acquired Immunity ◽  
Cholesterol Accumulation

scholarly journals Dendritic Cells Are Host Cells for Mycobacteria In Vivo That Trigger Innate and Acquired Immunity

2002 ◽  
Vol 168 (3) ◽  
pp. 1294-1301 ◽  
Author(s):  
Xinan Jiao ◽  
Richard Lo-Man ◽  
Pierre Guermonprez ◽  
Laurence Fiette ◽  
Edith Dériaud ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Host Cells ◽  
Acquired Immunity
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