Compared with vitamin A plus iron and multiple micronutrient supplementations, solely vitamin A fortified seasoning powder affect iron metabolic index without changing body total iron contents in children

2010 ◽  
Vol 34 (8) ◽  
pp. S66-S66
Author(s):  
Ke Chen ◽  
TingYu Li ◽  
Li Chen ◽  
Ping Qu ◽  
YouXue Liu
1998 ◽  
Vol 19 (2) ◽  
pp. 168-171 ◽  
Author(s):  
Denis Barclay

Diet-related micronutrient deficiencies rarely occur in isolation; deficiencies of iodine and vitamin A or of iron and vitamin A or zinc are often observed in the same populations. In addition, widespread deficiencies of some micronutrients, for example, zinc and calcium, may often go undiagnosed because of the absence of specific and sensitive status indicators. Multiple micronutrient supplementation can be more effective in improving nutritional status than supplementation with single key micronutrients; therefore, the multiple fortification of appropriate food vectors, including beverages, is of interest from the nutritional standpoint. Beverages fortified with multiple micronutrients include dairy products, chocolate beverages, fruit juices, and soya-based drinks. As well as the documented or estimated micronutrient deficiencies and the requirements of the target population or consumer group, the conception of such a multiply fortified beverage must take into account a number of other important factors. The choice of the chemical form of the fortification micronutrients should be made with consideration of bioavailability, the effects on the organoleptic characteristics of the particular beverage, and cost. The initial calculation of the composition of the micronutrient premix should include the levels of micronutrients in the raw materials used and the estimated losses of specific micronutrients during processing and storage. Preliminary production and storage trials are then needed to determine the actual losses. The composition of the micronutrient premix may then be finalized. Interactions, both positive and negative, between fortification micronutrients may also need to be considered. For example, the bioavailability of iron may be enhanced by the addition of vitamin C, whereas mineral–vitamin and vitamin–vitamin interactions can accelerate the destruction of some vitamins. To render quality control procedures simple and cost-effective, only a limited number of fortification micronutrients, which are especially sensitive to losses and which are easy to measure, may be analysed. Simple, inexpensive, and rigorous analytical methods for such measurements are now available.


Nutrition ◽  
2011 ◽  
Vol 27 (4) ◽  
pp. 428-434 ◽  
Author(s):  
Ke Chen ◽  
Xuan Zhang ◽  
Ting-yu Li ◽  
Li Chen ◽  
Xiao-ping Wei ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ngan T. D. Hoang ◽  
Liliana Orellana ◽  
Rosalind S. Gibson ◽  
Tuyen D. Le ◽  
Anthony Worsley ◽  
...  

AbstractWe aimed to determine the efficacy of multiple micronutrient supplementation on the biomarkers of iron, zinc, and vitamin A status across anthropometric status categories in Vietnamese school children. In this 22-week randomised controlled trial, 347 undernourished, normal weight, or overweight/obese children aged 6–9 years were allocated to receive every school day a multiple micronutrient supplement (10 mg iron, 10 mg zinc, 400 µg vitamin A) or a placebo. Haematological indices; circulating ferritin, zinc, and retinol (corrected for inflammation); and C-reactive protein were measured at baseline and 22 weeks. At week 22, linear mixed models showed that mean corpuscular volume increased by 0.3 fL, serum ferritin by 9.1 µg/L, plasma zinc by 0.9 µmol/L, and plasma retinol by 15%, and the prevalence of zinc deficiency decreased by 17.3% points in the intervention group compared to placebo. No intervention effects were found for other haematological indices, or the prevalence of anaemia. Multiple micronutrient supplementation for 22 weeks improved the biomarkers of zinc and vitamin A status and some biomarkers of iron status, and reduced the prevalence of zinc deficiency in Vietnamese school children.Trial registration: This trial was registered on 06/09/2016 at www.anzctr.org.au as ACTRN12616001245482.


2016 ◽  
Vol 13 (4) ◽  
Author(s):  
Lara Livia Santos Silva ◽  
Rosângela Aparecida Augusto ◽  
Daniela Cardoso Tietzmann ◽  
Leopoldina Augusta Souza Sequeira ◽  
Maria Claret Costa Monteiro Hadler ◽  
...  

2007 ◽  
Vol 137 (9) ◽  
pp. 2147-2153 ◽  
Author(s):  
S. M. Ziauddin Hyder ◽  
Farhana Haseen ◽  
Marufa Khan ◽  
Tom Schaetzel ◽  
Chowdhury S. B. Jalal ◽  
...  

2003 ◽  
Vol 24 (4_suppl_1) ◽  
pp. S111-S119 ◽  
Author(s):  
Haile Mehansho ◽  
Renee I. Mellican ◽  
Don L. Hughes ◽  
Don B. Compton ◽  
Tomas Walter

At the World Summit for Children (New York, 1990), a resolution was passed to eliminate vitamin A and iodine deficiencies and significantly reduce iron-deficiency anemia by the year 2000. In responding to this urgent call, we developed a unique multiple-micronutrient fortification delivery system called “GrowthPlus/CreciPlus®.” Using this technology, a fortified powder fruit drink has been formulated and extensively evaluated. One serving of the product delivers the following US recommended dietary allowances: 20–30% of iron; 10–35% of vitamin A; 25–35% of iodine; 100–120% of vitamin C; 25–35% of zinc; 15–35% of folate; and 10–50% of vitamins E, B2, B6, and B12. This was accomplished through (a) identifying and selecting the right fortificants, and (b) understanding their chemical and physical properties that contribute to multiple problems (product acceptability, stability, and bioavailability). Data from a home-use test showed fortification with the “Multiple-Fortification Technology” has no effect on the appearance and taste of the eventually consumed powder fruit drink. One-year stability studies demonstrated that iodine and the vitamins have adequate stability. Bioavailability evaluation by using double-isotope labeling technique showed that the iron from the fortified powder drink has excellent bioavailability (23.4% ± 6.7). In conclusion, a powder fruit drink has been clinically demonstrated to deliver multiple micronutrients, which include adequate levels of bioavailable iron, vitamin A, iodine, zinc, vitamin C, and B vitamins, without compromising taste, appearance, and bioavailability. The critical limiting step in the micronutrient fortification program is the production and distribution of the multiplemicronutrient-fortified product. The fortified powder drink was marketed in Venezuela under the brand name NutriStar®.


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