STK31 acts as a cell fate determinant in spermatogonial stem cell

2010 ◽  
Vol 34 (8) ◽  
pp. S37-S37
Author(s):  
Kin Lam Ellis Fok ◽  
Chin Man Chung ◽  
Hsiao Chang Chan
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Spermatogonial Stem Cell ◽  
Cell Fate Determinant ◽  
A Cell

335 Divergent VEGFA signaling determines spermatogonial stem cell fate

2016 ◽  
Vol 94 (suppl_2) ◽  
pp. 157-158
Author(s):  
K. M. Sargent ◽  
J. R. Essink ◽  
M. L. Bremer ◽  
W. E. Pohlmeier ◽  
M. M. Laughlin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Fate

scholarly journals Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Jarmon G. Lees ◽  
David K. Gardner ◽  
Alexandra J. Harvey
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Nutrient Availability ◽  
Cell Metabolism ◽  
Embryonic Stem ◽  
Glutamine Metabolism ◽  
Preimplantation Embryo Development ◽  
A Cell ◽  
Species Production ◽  
Cell Growth And Proliferation

Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highlighted by extensive studies of their impact on preimplantation embryo development, physiology, and viability. ESC similarly modulate their metabolism in response to altered metabolite levels, with changes in nutrient availability shown to have a lasting impact on derived cell identity through the regulation of the epigenetic landscape. Further, the preferential use of glucose and anaplerotic glutamine metabolism serves to not only support cell growth and proliferation but also minimise reactive oxygen species production. However, the perinuclear localisation of spherical, electron-poor mitochondria in ESC is proposed to sustain ESC nuclear-mitochondrial crosstalk and a mitochondrial-H2O2presence, to facilitate signalling to support self-renewal through the stabilisation of HIFα, a process that may be favoured under physiological oxygen. The environment in which a cell is grown is therefore a critical regulator and determinant of cell fate, with metabolism, and particularly mitochondria, acting as an interface between the environment and the epigenome.

The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells

2010 ◽  
Vol 30 (5) ◽  
pp. 403-408 ◽  
Author(s):  
Hyo-Jung Park ◽  
Jun-Kyum Kim ◽  
Hye-Min Jeon ◽  
Se-Yeong Oh ◽  
Sung-Hak Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Glioma Stem Cells ◽  
Stem Cell Fate ◽  
Cell Fate Determinant

Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast

Nature ◽  
10.1038/38015 ◽  
1997 ◽  
Vol 389 (6646) ◽  
pp. 90-93 ◽  
Author(s):  
Peter A. Takizawa ◽  
Anita Sil ◽  
Jason R. Swedlow ◽  
Ira Herskowitz ◽  
Ronald D. Vale
Keyword(s):  
Cell Fate ◽  
Cell Fate Determinant ◽  
A Cell

scholarly journals Erratum to: The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells

2011 ◽  
Vol 31 (2) ◽  
pp. 199-199 ◽  
Author(s):  
Hyo-Jung Park ◽  
Jun-Kyum Kim ◽  
Hye-Min Jeon ◽  
Se-Yeong Oh ◽  
Sung-Hak Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Glioma Stem Cells ◽  
Stem Cell Fate ◽  
Cell Fate Determinant

scholarly journals Feed-Forward Regulation of a Cell Fate Determinant by an RNA-Binding Protein Generates Asymmetry in Yeast

Genetics ◽  
2010 ◽  
Vol 185 (2) ◽  
pp. 513-522 ◽  
Author(s):  
Joshua J. Wolf ◽  
Robin D. Dowell ◽  
Shaun Mahony ◽  
Michal Rabani ◽  
David K. Gifford ◽  
...  
Keyword(s):  
Cell Fate ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Feed Forward ◽  
Cell Fate Determinant ◽  
A Cell

scholarly journals Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell

2015 ◽  
Vol 211 (4) ◽  
pp. 737-739 ◽  
Author(s):  
Marisa M. Faraldo ◽  
Marina A. Glukhova
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Cell Expansion ◽  
Progenitor Cell ◽  
Asymmetric Cell Divisions ◽  
Stem Cell Expansion ◽  
Cell Divisions ◽  
Cell Fate Determinant ◽  
Mammary Stem

In this issue, Tosoni et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505037) report that cell fate determinant and tumor suppressor Numb imposes asymmetric cell divisions in mammary stem cells by regulating p53. Numb thereby restricts mammary stem cell expansion and controls the proliferation and lineage-specific characteristics of their progeny.

scholarly journals Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling

2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Yuke Shu ◽  
Qing Xu ◽  
Yahong Xu ◽  
Qing Tao ◽  
Mingyang Shao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Cell Fate ◽  
Malignant Transformation ◽  
Intrahepatic Cholangiocarcinoma ◽  
Stem Cell Markers ◽  
Notch Intracellular Domain ◽  
Chemically Induced ◽  
Secretase Inhibitor ◽  
Cell Fate Determinant

AbstractNumb, a stem cell fate determinant, acts as a tumor suppressor and is closely related to a wide variety of malignancies. Intrahepatic cholangiocarcinoma (iCCA) originates from hepatic progenitors (HPCs); however, the role of Numb in HPC malignant transformation and iCCA development is still unclear. A retrospective cohort study indicated that Numb was frequently decreased in tumor tissues and suggests poor prognosis in iCCA patients. Consistently, in a chemically induced iCCA mouse model, Numb was downregulated in tumor cells compared to normal cholangiocytes. In diet-induced chronic liver injury mouse models, Numb ablation significantly promoted histological impairment, HPC expansion, and tumorigenesis. Similarly, Numb silencing in cultured iCCA cells enhanced cell spheroid growth, invasion, metastasis, and the expression of stem cell markers. Mechanistically, Numb was found to bind to the Notch intracellular domain (NICD), and Numb ablation promoted Notch signaling; this effect was reversed when Notch signaling was blocked by γ-secretase inhibitor treatment. Our results suggested that loss of Numb plays an important role in promoting HPC expansion, HPC malignant transformation, and, ultimately, iCCA development in chronically injured livers. Therapies targeting suppressed Numb are promising for the treatment of iCCA.

The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function

Leukemia ◽  
2018 ◽  
Vol 32 (5) ◽  
pp. 1211-1221 ◽  
Author(s):  
Juliane Mohr ◽  
Banaja P. Dash ◽  
Tina M. Schnoeder ◽  
Denise Wolleschak ◽  
Carolin Herzog ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Hematopoietic Stem ◽  
Cell Fate Determinant
Sign in / Sign up

Export Citation Format

Share Document