Burkholderia pseudomallei pathogenesis and survival in different niches

2020 ◽  
Vol 48 (2) ◽  
pp. 569-579
Author(s):  
Chee-Hoo Yip ◽  
Ahmad-Kamal Ghazali ◽  
Sheila Nathan

Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a disease of the tropics with high clinical mortality rates. To date, no vaccines are approved for melioidosis and current treatment relies on antibiotics. Conversely, common misdiagnosis and high pathogenicity of Bp hamper efforts to fight melioidosis. This bacterium can be isolated from a wide range of niches such as waterlogged fields, stagnant water bodies, salt water bodies and from human and animal clinical specimens. Although extensive studies have been undertaken to elucidate pathogenesis mechanisms of Bp, little is known about how a harmless soil bacterium adapts to different environmental conditions, in particular, the shift to a human host to become a highly virulent pathogen. The bacterium has a large genome encoding an armory of factors that assist the pathogen in surviving under stressful conditions and assuming its role as a deadly intracellular pathogen. This review presents an overview of what is currently known about how the pathogen adapts to different environments. With in-depth understanding of Bp adaptation and survival, more effective therapies for melioidosis can be developed by targeting related genes or proteins that play a major role in the bacteria's survival.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kai Yan ◽  
Chun-lian Wang ◽  
Steffen Mischke ◽  
Jiu-yi Wang ◽  
Li-jian Shen ◽  
...  

AbstractMajor, trace and rare earth element (REE) geochemistry of the late Cretaceous lower Zhoutian Formation from the Jitai Basin of Southeast China were measured by inductively coupled plasma mass spectrometry (ICP-MS) analysis to infer the provenance of the sediments and to reconstruct the palaeoenvironment and palaeoclimate. The wide range of Sr/Cu ratios point to a fluctuating palaeoclimate, and the negative correlation between the FeO/MnO and Al2O3/MgO ratios and the Sr/Cu ratio indicates that the late Cretaceous climate during the lower Zhoutian Formation in the Jitai Basin can be divided into two parts. The lower part experienced two cooling periods, whilst the upper part was dominated by warm-humid climate. Mostly corresponding trends of the B/Ga, Sr/Ba and Sr/Cu ratios show that the salinity changed consistently with the late Cretaceous climate during the lower Zhoutian Formation in the Jitai Basin. During the lower part, the salinity changed from salt water to fresh/brackish water. In the upper part, water was mainly fresh/brackish, and there were many changes from fresh/brackish water to salt water. The relatively stable Ni/Co, V/Cr, V/(V + Ni) and Ce/Ce* data indicate a long period of oxic conditions. The La-Th-Sc, Th-Sc-Zr/10 and La/Th-Hf data of the silt- and sandstones of the lower Zhoutian Formation show that its provenance was mainly a mixture of felsic upper crust sediments and older sedimentary rocks.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Verónica Gamón ◽  
Isabel Hurtado ◽  
José Salazar-Fraile ◽  
Gabriel Sanfélix-Gimeno

AbstractSchizophrenia is a chronic mental condition presenting a wide range of symptoms. Although it has a low prevalence compared to other mental conditions, it has a negative impact on social and occupational functions. This study aimed to assess the appropriateness of antipsychotic medications administered to schizophrenic patients and describe current treatment patterns for schizophrenia. A retrospective cohort study was conducted in all patients over the age of 15 with an active diagnosis of schizophrenia and treated with antipsychotics between 2008 and 2013 in the Valencia region. A total of 19,718 patients were eligible for inclusion. The main outcome assessed was inappropriateness of the pharmacotherapeutic management, including polypharmacy use. Altogether, 30.4% of patients received antipsychotic polypharmacy, and 6.8% were prescribed three or more antipsychotics. Overdosage affected 318 individuals (1.6%), and 21.5% used concomitant psychotropics without an associated psychiatric diagnosis. Women and people with a comorbid condition like anxiety or depression were less likely to receive antipsychotic polypharmacy. In contrast, increased polypharmacy was associated with concomitant treatment with other psychoactive drugs, and only in user on maintenance therapy, with more visits to the mental health hospital. Overall, we observed a high level of inappropriateness in antipsychotic prescriptions. Greater adherence to guidelines could maximize the benefits of antipsychotic medications while minimizing risk of adverse effects.


Parasitology ◽  
1993 ◽  
Vol 107 (S1) ◽  
pp. S159-S167 ◽  
Author(s):  
P. S. Shetty ◽  
N. Shetty

Interactions between infection and nutrition have been well recognized for several years now since they contribute directly to the health of individuals and communities. Malnourished individuals are specially prone to developing infections while infections themselves can lead to profound changes in the nutritional status of the individual. Health workers in developing countries in the tropics have long recognized the mutually aggravating interactions of malnutrition and infection. The importance of this synergistic relationship between infection and nu-tritional status has been studied extensively in the case of young children. The nutritional status of a young child is a critical determinant of both c morbidity and mortality resulting from a wide range of infections: bacterial, viral, or parasitic. Chandra (1983), in his review on the relationship of nutrition, immunity and infection has categorized the wide range of infectious agents (bacterial, viral, fungal and parasitic) into those that are definitely, variably or minimally influenced by the nutritional status of the child.


2019 ◽  
Author(s):  
Pierre Gentine ◽  
Adam Massmann ◽  
Benjamin R. Lintner ◽  
Sayed Hamed Alemohammad ◽  
Rong Fu ◽  
...  

Abstract. The continental tropics play a leading role in the terrestrial water and carbon cycles. Land–atmosphere interactions are integral in the regulation of surface energy, water and carbon fluxes across multiple spatial and temporal scales over tropical continents. We review here some of the important characteristics of tropical continental climates and how land–atmosphere interactions regulate them. Along with a wide range of climates, the tropics manifest a diverse array of land–atmosphere interactions. Broadly speaking, in tropical rainforests, light and energy are typically more limiting than precipitation and water supply for photosynthesis and evapotranspiration; whereas in savanna and semi-arid regions water is the critical regulator of surface fluxes and land–atmosphere interactions. We discuss the impact of the land surface, how it affects shallow clouds and how these clouds can feedback to the surface by modulating surface radiation. Some results from recent research suggest that shallow clouds may be especially critical to land–atmosphere interactions as these regulate the energy budget and moisture transport to the lower troposphere, which in turn affects deep convection. On the other hand, the impact of land surface conditions on deep convection appear to occur over larger, non-local, scales and might be critically affected by transitional regions between the climatologically dry and wet tropics.


2021 ◽  
Vol 38 ◽  
pp. 115-117
Author(s):  
C.N. Greenwell ◽  
◽  

Ruddy Turnstones Arenaria interpres have been identified as egg-predators at seabird and shorebird colonies, including gull and tern colonies in the tropics and Northern Hemisphere. The Australian Fairy Tern Sternula nereis nereis is a threatened (Environment Protection and Biodiversity Conservation Act 1999: Vulnerable) coastal seabird, whose breeding behaviour and ecology expose it to a wide range of threats. This study describes inferred predation on Fairy Tern eggs at a small breeding colony on Rottnest Island, Western Australia, by Ruddy Turnstones, a previously unsuspected predator for thisspecies. Unlike the behavioural response shown towards Silver Gulls Larus novaehollandiae and Australian Ravens Corvus coronoides, which includes collective group defence and dive-bombing, Fairy Terns showed a lack of aggression towards Turnstones within the colony. The lack of a behavioural response suggests that the Terns did not recognise the Turnstones as predators, which may increase the risk of egg-predation. This study suggests that we should be alert to threats from unsuspected predators, which have the potential to reduce the breeding success of this Vulnerable tern.


Climate ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 168
Author(s):  
Julien Boucharel ◽  
Loane Santiago ◽  
Rafael Almar ◽  
Elodie Kestenare

At first order, wind-generated ocean surface waves represent the dominant forcing of open-coast morpho-dynamics and associated vulnerability over a wide range of time scales. It is therefore paramount to improve our understanding of the regional coastal wave variability, particularly the occurrence of extremes, and to evaluate how they are connected to large-scale atmospheric regimes. Here, we propose a new “2-ways wave tracking algorithm” to evaluate and quantify the open-ocean origins and associated atmospheric forcing patterns of coastal wave extremes all around the Pacific basin for the 1979–2020 period. Interestingly, the results showed that while extreme coastal events tend to originate mostly from their closest wind-forcing regime, the combined influence from all other remote atmospheric drivers is similar (55% local vs. 45% remote) with, in particular, ~22% coming from waves generated remotely in the opposite hemisphere. We found a strong interconnection between the tropical and extratropical regions with around 30% of coastal extremes in the tropics originating at higher latitudes and vice-versa. This occurs mostly in the boreal summer through the increased seasonal activity of the southern jet-stream and the northern tropical cyclone basins. At interannual timescales, we evidenced alternatingly increased coastal wave extremes between the western and eastern Pacific that emerge from the distinct seasonal influence of ENSO in the Northern and SAM in the Southern Hemisphere on their respective paired wind-wave regimes. Together these results pave the way for a better understanding of the climate connection to wave extremes, which represents the preliminary step toward better regional projections and forecasts of coastal waves.


2009 ◽  
Vol 9 (15) ◽  
pp. 5847-5864 ◽  
Author(s):  
J. S. Wright ◽  
R. Fu ◽  
A. J. Heymsfield

Abstract. The factors that control the influence of deep convective detrainment on water vapor in the tropical upper troposphere are examined using observations from multiple satellites in conjunction with a trajectory model. Deep convection is confirmed to act primarily as a moisture source to the upper troposphere, modulated by the ambient relative humidity (RH). Convective detrainment provides strong moistening at low RH and offsets drying due to subsidence across a wide range of RH. Strong day-to-day moistening and drying takes place most frequently in relatively dry transition zones, where between 0.01% and 0.1% of Tropical Rainfall Measuring Mission Precipitation Radar observations indicate active convection. Many of these strong moistening events in the tropics can be directly attributed to detrainment from recent tropical convection, while others in the subtropics appear to be related to stratosphere-troposphere exchange. The temporal and spatial limits of the convective source are estimated to be about 36–48 h and 600–1500 km, respectively, consistent with the lifetimes of detrainment cirrus clouds. Larger amounts of detrained ice are associated with enhanced upper tropospheric moistening in both absolute and relative terms. In particular, an increase in ice water content of approximately 400% corresponds to a 10–90% increase in the likelihood of moistening and a 30–50% increase in the magnitude of moistening.


2021 ◽  
Author(s):  
Stefan Schlaffer ◽  
Marco Chini ◽  
Wouter Dorigo

<p>The North American Prairie Pothole Region (PPR) consists of millions of wetlands and holds great importance for biodiversity, water storage and flood management. The wetlands cover a wide range of sizes from a few square metres to several square kilometres. Prairie hydrology is greatly influenced by the threshold behaviour of potholes leading to spilling as well as merging of adjacent wetlands. The knowledge of seasonal and inter-annual surface water dynamics in the PPR is critical for understanding this behaviour of connected and isolated wetlands. Synthetic aperture radar (SAR) sensors, e.g. used by the Copernicus Sentinel-1 mission, have great potential to provide high-accuracy wetland extent maps even when cloud cover is present. We derived water extent during the ice-free months May to October from 2015 to 2020 by fusing dual-polarised Sentinel-1 backscatter data with topographical information. The approach was applied to a prairie catchment in North Dakota. Total water area, number of water bodies and median area per water body were computed from the time series of water extent maps. Surface water dynamics showed strong seasonal dynamics especially in the case of small water bodies (< 1 ha) with a decrease in water area and number of small water bodies from spring throughout summer when evaporation rates in the PPR are typically high. Larger water bodies showed a more stable behaviour during most years. Inter-annual dynamics were strongly related to drought indices based on climate data, such as the Palmer Drought Severity Index. During the extremely wet period of late 2019 to 2020, the dynamics of both small and large water bodies changed markedly. While a larger number of small water bodies was encountered, which remained stable throughout the wet period, also the area of larger water bodies increased, partly due to merging of smaller adjacent water bodies. The results demonstrate the potential of Sentinel-1 data for long-term monitoring of prairie wetlands while limitations exist due to the rather low temporal resolution of 12 days over the PPR.</p>


2021 ◽  
Author(s):  
Thorsten Fehr ◽  
Gail Skofronick-Jackson ◽  
Vassilis Amiridis ◽  
Jonas von Bismarck ◽  
Shuyi Chen ◽  
...  

<p>The Tropics are covering around 40% of the globe and are home to approximately 40% of the world population. However, numerical weather prediction (NWP) for this region still remains challenging due to the lack of basic observations and incomplete understanding of atmospheric processes, also affecting extratropical storm developments. As a result, the largest impact of the ESA’s Aeolus satellite observations on NWP is expected in the Tropics where only a very limited number of wind profile observations from the ground can be performed.</p><p>An especially important case relating to the predictability of tropical weather system is the outflow of Saharan dust, its interaction with cloud micro-physics and the overall impact on the development of tropical storms over the Atlantic Ocean. The region of the coast of West Africa uniquely allows the study of the Saharan Aerosol layer, African Easterly Waves and Jets, Tropical Easterly Jet, as well as the deep convection in ITCZ and their relation to the formation of convective systems and the transport of dust.</p><p>Together with international partners, ESA and NASA are currently implementing a joint Tropical campaign from July to August 2021 with its base in Cape Verde. The campaign objective is to provide information on the validation and preparation of the ESA missions Aeolus and EarthCARE, respectively, as well as supporting a range of related science objectives for the investigation in the interactions between African Easterly and other tropical waves with the mean flow, dust and their impact on the development of convective systems; the structure and variability of the marine boundary layer in relation to initiation and lifecycle of the convective cloud systems within and across the ITCZ; and impact of wind, aerosol, clouds, and precipitation effects on long range dust transport and air quality over the western Atlantic.</p><p>The campaign comprises a unique combination of both strong airborne and ground-based elements collocated on Cape Verde. The airborne component with wind and aerosol lidars, cloud radars, in-situ instrumentation and additional observations includes the NASA DC-8 with science activities coordinated by the U. of Washington, the German DLR Falcon-20, the French Safire Falcon-20 with activities led by LATMOS, and the Slovenian Aerovizija Advantic WT-10 light aircraft in cooperation with the U. Novo Gorica. The ground-based component led by the National Observatory of Athens is a collaboration of more than 25 European teams providing in-situ and remote sensing aerosol and cloud measurements with a wide range of lidar, radar and radiometer systems, as well as drone observatins by the Cyprus Institute.</p><p>In preparation for the field campaign, the NASA and ESA management and science teams are closely collaborating with regular coordination meetings, in particular in coordinating the shift of the activity by one year due to the COVID-19 pandemic. The time gained has been used to further consolidate the planning, and in particular with a dry-run campaign organized by NASA with European participation where six virtual flights were conducted in July 2020.</p><p> This paper will present a summary of the campaign preparation activities and the consolidated plan for the 2021 Tropical campaign.</p>


Author(s):  
Peter A. Furley

What are savannas and where are they? ‘Savanna landscapes’ considers these dynamic and diverse biomes—the most widespread form of vegetation in the tropics and sub-tropics. They are areas covered by a nearly continuous grassy layer, interspersed with trees and shrubs of varying densities and heights, but their nature and distribution is affected by the local topography and is closely allied with continental evolution. Marked seasonal variation is characterized by unpredictably long wet or dry spells and there is a wide range of flora and fauna across the major continental savannas. There are numerous theories on the role of savannas in shaping the emergence and spread of human populations.


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