scholarly journals Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family

2013 ◽  
Vol 41 (4) ◽  
pp. 1066-1071 ◽  
Author(s):  
Olga Mayans ◽  
Guy M. Benian ◽  
Felix Simkovic ◽  
Daniel J. Rigden

The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinity. In the present article, we discuss the speciation of mechanosensory mechanisms in titin-like kinases, their scaffolding properties and the kinase/pseudokinase domain variations that define a rich functional diversity across the family.

2009 ◽  
Vol 1793 (11) ◽  
pp. 1738-1748 ◽  
Author(s):  
Natalia de Miguel ◽  
Nathalie Braun ◽  
Alexander Bepperling ◽  
Thomas Kriehuber ◽  
Andreas Kastenmüller ◽  
...  

1995 ◽  
Vol 10 (2) ◽  
pp. 169-198
Author(s):  
David Postles

Le présent article, à partir d'une étude détaillée du changement dans les sociétés locales, s'attache à la transformation radicale de la façon dont on attribue un nom dans l'Angleterre des XIIIe-XVe siècles. De subtiles nuances se font jour quant au changement lié à une réciprocité de plusieurs facteurs. II ne s'agit pas seulement de l'impact des changements démographiques et culturels, mais aussi de l'influence de l'organisation sociale et de la seigneurie. Alors que la ‘diffusion’ sociale joue un rôle important dans les diverses façons d'attribuer les noms, l'accueil de cette évolution selon les groupes sociaux varie. Cela est mis en lumière dans la paysannerie serve. Bien que les documents ne fournissent qu'une vue formelle et imposée des noms que l'on donne, il y a moyen de ne pas se laisser abuser et de retracer l'essentiel du processus oral de dénomination familière.


2020 ◽  
Author(s):  
А.Б. Бритаева

В представленной статье на материале произведений Музафера Дзасохова известного современного осетинского писателя, поэта, публициста, переводчика, рассматриваются художественные особенности лирической прозы, а именно, автобиографической повести в осетинской детской литературе. Повесть Весенние звезды (1973) и ее продолжение На берегу Уршдона Барагун (1981) стали началом эпопеи о жизни отдельно взятой семьи, а на их примере всей страны в тяжелые послевоенные годы. В качестве одной из важнейших констант художественного мира писателя рассматривается образ детства. В ходе анализа особое внимание уделяется преобладанию нравственного аспекта, актуализации проблемы регулятивно-воспитательной функции национального этикета, ценностно-нормативных ориентиров осетинской ментальности. С опорой на биографический и историко-генетический методы, основное внимание в исследовании акцентируется на темах послевоенного детства, роли семьи и общества в формировании нравственных ориентиров, в становлении личности, образе матери, теме памяти, а также на художественном осмыслении этих проблем и тем в автобиографических повестях писателя. Типологически воплощение детской темы в творчестве М. Дзасохова во многом опирается на традицию изображения детства в русской автобиографической прозе XX в. В заключительной части сформулированы выводы, отражающие особенности лирической прозы в творчестве М. Дзасохова, обозначено место автобиографических повестей автора в контексте осетинской детской литературы второй половины XX века.Актуальность и научная новизна работы обусловлены недостаточной исследованностью истории и проблем осетинской детской литературы. Результаты исследования могут быть использованы при написании истории осетинской детской литературы. The present article examines the artistic features of lyrical prose, namely, autobiographical story in the Ossetian childrens literature in the works of Muzafer Dzasokhov, a well-known modern Ossetian writer, poet, publicist, translator. The story Spring Stars (1973) and its continuation - On the Bank of Ursdon Baragun ... (1981) marked the beginning of an epic about the life of a family, and via their fates the author shows life of the whole country in the difficult post-war years. The theme of childhood is considered as one of the most important constants of the writers artistic world. In the course of the analysis, special attention is paid to the predominance of the moral aspect, the actualization of the problem of the regulatory and educational function of national etiquette, the value and normative guidelines of the Ossetian mentality. The focus of the study is based on biographical and historical-genetic methods and highlights the themes of post-war childhood, the role of the family and society in the formation of moral guidelines, in the formation of personality, the image of the mother, the theme of memory, as well as on the artistic understanding of these problems and topics in autobiographical novels of the writer. Typologically, the embodiment of the childrens theme in the works of M. Dzasokhov is largely based on the tradition of depicting childhood in Russian autobiographical prose of the XXth century. The formulated conclusions in the final part reflect the peculiarities of lyrical prose in the works of M. Dzasokhov, the place of the authors autobiographical stories is indicated in the context of Ossetian childrens literature of the second half of the XXth century. The relevance and scientific novelty of the work are due to insufficient research on the history and problems of Ossetian childrens literature. The results of the study can be used in writing the history of Ossetian childrens literature.


2007 ◽  
Vol 2 (1) ◽  
pp. 47-136
Author(s):  
W. South Coblin

The present article compares data from seven Huīzhōu dialects in an effort to construct a common phonological system for the family as a whole. In the final section of the paper it is concluded that this dialect group is probably an areal or geographical grouping rather than a genetically related dialect family.


2017 ◽  
Vol 2 (1) ◽  
pp. 7 ◽  
Author(s):  
Wanda Stojanowska

THE OPINION OF THE FAMILY DIAGNOSTIC-ADVISORY CENTRE AS THE EVIDENCE IN DIVORCE CASES AND ITS INFLUENCE ON JUDGEMENTS (IN THE LIGHT OF C OURT RECORDS)Summary The present article contains results of studies conducted in the Institute of Justice in Warsaw. Basis for the research was 100 judgments in divorce cases by Polish provincial courts from 1997 to 1998. Each of the examined judgments was done after hearing by court of the Family Diagnostic - Advisory Centre (FDAC) opinion in cases including decision as to the guilt for breaking up of marriage and subsequent granting of the paternal authority to the innocent party. The study is going to establish relation between opinions by the FDAC and judgments.The study contains complex and detailed analysis of court decision and its grounds. It shows that opinion given by FDAC is very influential for courts granting judgments which followed it in 80% of analyzed cases. However not all of the suggestions given by experts were relevant. In the majority of the examined cases a mistake made by the expert consisted of the ignorance of law and consequendy of the ambiguous wording of the opinion. Such an opinion was then followed by the judge who usually chose the simplest solution granting the full parental authority to both of the divorced spouses thus avoiding the time consuming and laborious procedure based on the article 58 of the Code of Family and Guardianship Law determining possibility of limitation of the parental authority.Such approach could be declared as an opportunistic one, and provokes postulate de lege ferenda for abolishment of the institution of granting the full parental authority to both of the divorced spouses. Proposed change should simplify courts procedure as well as enable the FDEC to develop its activity as family advisory centers which until now does not exist in Polish legal system.


2019 ◽  
Vol 11 (14) ◽  
pp. 14899-14901
Author(s):  
Jatishwor Singh Irungbam ◽  
Meenakshi Jatishwor Irungbam

In the present article, we report the first record of the moth, Ethmia lineatonotella (Moore, 1867) family Depressariidae, subfamily Ethmiinae from Mendrelgang village of Tsirang district, Bhutan. The species is the second known species from the family, so far only Ethmia assamensis was recorded from Bhutan.  


Comunicar ◽  
2005 ◽  
Vol 13 (25) ◽  
Author(s):  
Ana-Luisa Fernandes-Gonçalves

The present article is about the presence of the tv in the society, in general, and its potential as an important agent, such as the family and the school, on the children’s and young people’s development and education. Nowadays we live in a complex world of images with sound, the most of them transmitted by the tv, the cinema and the internet. The infantile universe is full of those images. This way we structured this article in four parts, refering some of the contents related with this subject. The first part describes the presence of the television in the children's daylife and their relationship with the magic box, even the identification that they make with its favourites characters, in order to understand the space that the TV occupies in their lives. The second part presents the different messages transmitted by the television. It is important to analyze the main risks and advantages of television, that is to say, in spite of some programs show bad values, foment the excessive consumption, expose the children to an atmosphere of violence and pornography, also entertains, accompanies, educates, informs, favours the access to the culture and allows to unite the family around a program. At last the third part, this one outlines the necessity to put the tele as a curricular resource in the school, to teaches the students how to analyze, how to criticize and to think about the texts and the news of the world today. The television, considered a powerful tool, is decisive in the communication, such in the formation of values and ideas as in the culture transmission. The function of the school is not to remain far from this factor, but to try to meditate, to understand and to decide its impact, in a better way, on the development of the children and youngs. As conclusion we can add that we’ve tried to aim some strategies that educators and parents will be able to work, united to the children and the youngs, so they could have a new look of the Tv’s world and that they could know how to make their own selection and how to have a critical attitude before the watched product.La presente comunicación se refiere a la presencia de la tele en la sociedad en general y a su potencial como agente importante de formación y educación, junto con la escuela y la familia, en la vida de los niños y de los jóvenes. Actualmente vivimos inmersos en un mundo complejo de imágenes con sonido, que recibimos muy especialmente a través de la tele, del cine y de Internet, los cuales hacen parte del cotidiano del universo infantil. Así, a fin de organizar algunos de los contenidos desde los que es posible enfocar el tema, estructuramos este artículo en cuatro partes. La primera parte describe la presencia de la tele a diario de los niños y su relación con la caja mágica, incluso la identificación que hacen de sus personajes favoritos, a fin de comprender el espacio que ocupa la tele en su cotidianidad. La segunda parte presenta los distintos mensajes transmitidos por la tele. Es importante analizar las principales riesgos y ventajes de la televisión, o sea, a pesar de algunos programas muestran antivalores de la tele: fomentar excesivamente el consumo, exponer a los niños a un ambiente de violencia y pornografía también entretiene, acompaña, educa, informa, favorece el acceso a la cultura y permite unir a la familia en torno a un programa. Cuanto a la tercera parte, plantea la necesidad de incorporar la tele como recurso curricular en la escuela, para que enseñe a los alumnos a analizar crítica y reflexivamente los textos mediáticos. La televisión es considerada como una herramienta poderosa, determinante en la comunicación, tanto en la formación de valores e ideas, como en la transmisión de cultura; la función de la escuela no es permanecer ajena a este factor, pero procurar reflexionar para comprender y decidir mejor su impacto en el desarrollo de los niños y jóvenes. Como conclusión podemos añadir que hemos tratado de apuntar algunas estrategias que educadores y padres podrán trabajar junto con los niños y los jóvenes, para que éstes tengan una nueva mirada del mundo de la tele y para que sepan hacer su propia selección y tener una actitud crítica ante el producto visionado.


Development ◽  
1999 ◽  
Vol 126 (23) ◽  
pp. 5285-5294 ◽  
Author(s):  
S. Garel ◽  
F. Marin ◽  
R. Grosschedl ◽  
P. Charnay

Ebf1/Olf-1 belongs to a small multigene family encoding closely related helix-loop-helix transcription factors, which have been proposed to play a role in neuronal differentiation. Here we show that Ebf1 controls cell differentiation in the murine embryonic striatum, where it is the only gene of the family to be expressed. Ebf1 targeted disruption affects postmitotic cells that leave the subventricular zone (SVZ) en route to the mantle: they appear to be unable to downregulate genes normally restricted to the SVZ or to activate some mantle-specific genes. These downstream genes encode a variety of regulatory proteins including transcription factors and proteins involved in retinoid signalling as well as adhesion/guidance molecules. These early defects in the SVZ/mantle transition are followed by an increase in cell death, a dramatic reduction in size of the postnatal striatum and defects in navigation and fasciculation of thalamocortical fibres travelling through the striatum. Our data therefore show that Ebf1 plays an essential role in the acquisition of mantle cell molecular identity in the developing striatum and provide information on the genetic hierarchies that govern neuronal differentiation in the ventral telencephalon.


1979 ◽  
Vol 16 (02) ◽  
pp. 261-273 ◽  
Author(s):  
Larry P. Ammann ◽  
Peter F. Thall

The probability generating functional (p.g.fl.) of a non-homogeneous Poisson cluster process is characterized in Ammann and Thall (1977) via a decomposition of the KLM measure of the process. This p.g.fl. representation is utilized in the present article to show that the family 𝒟 of Poisson cluster processes with a.s. finite clusters is invariant under a class of cluster transformations. Explicit expressions for the finite-dimensional count distributions, product moment measures, and the distribution of clusters are derived in terms of the KLM measure. It is also shown that an element of 𝒟 has no multiple events iff the points of each cluster are a.s. distinct.


1986 ◽  
Vol 56 (2) ◽  
pp. 282-290 ◽  
Author(s):  
Frank Fiers

The present article in a series on the harpacticoid copepods gathered during the West Indian expeditions of the University of Amsterdam deals with three species of the family Darcythompsoniidae: Darcythompsonia inopinata Smirnov, Leptocaris glaber n. sp., and Leptocaris echinatus n. sp. Through comparison with other specimens from different localities, Darcythompsonia radans Por is considered here a synonym of D. inopinata Smirnov.


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