Topological constraints and chromosome organization in eukaryotes: a physical point of view

2013 ◽  
Vol 41 (2) ◽  
pp. 612-615 ◽  
Author(s):  
Angelo Rosa
Keyword(s):  
Experimental Evidence ◽  
Three Dimensional ◽  
Point Of View ◽  
Level Of Detail ◽  
Chromosome Organization ◽  
Physical Point ◽  
Topological Constraints ◽  
Polymer Models ◽  
Quantitative Understanding ◽  
Eukaryotic Genomes

New experimental tools capable of probing the three-dimensional organization of eukaryotic genomes with an unprecedented level of detail have been developed in the last few years. In the quest for a quantitative understanding of experimental results, several polymer models for chromatin organization were introduced and critically evaluated. In the present article, I give a brief introduction to the physical basis of chromosome organization, and recall the experimental evidence in favour of the importance of topological constraints for the description of chromosome conformations in eukaryotes.

scholarly journals Formation of corner waves in the wake of a partially submerged bluff body

2015 ◽  
Vol 771 ◽  
pp. 547-563 ◽  
Author(s):  
P. Martínez-Legazpi ◽  
J. Rodríguez-Rodríguez ◽  
A. Korobkin ◽  
J. C. Lasheras
Keyword(s):  
Bluff Body ◽  
Physical Mechanism ◽  
Essential Feature ◽  
Three Dimensional ◽  
Two Dimensions ◽  
Point Of View ◽  
Similar Solution ◽  
Physical Point ◽  
Self Similar Solution ◽  
Self Similar

We study theoretically and numerically the downstream flow near the corner of a bluff body partially submerged at a deadrise depth ${\rm\Delta}h$ into a uniform stream of velocity $U$, in the presence of gravity, $g$. When the Froude number, $\mathit{Fr}=U/\sqrt{g{\rm\Delta}h}$, is large, a three-dimensional steady plunging wave, which is referred to as a corner wave, forms near the corner, developing downstream in a similar way to a two-dimensional plunging wave evolving in time. We have performed an asymptotic analysis of the flow near this corner to describe the wave’s initial evolution and to clarify the physical mechanism that leads to its formation. Using the two-dimensions-plus-time approximation, the problem reduces to one similar to dam-break flow with a wet bed in front of the dam. The analysis shows that, at leading order, the problem admits a self-similar formulation when the size of the wave is small compared with the height difference ${\rm\Delta}h$. The essential feature of the self-similar solution is the formation of a mushroom-shaped jet from which two smaller lateral jets stem. However, numerical simulations show that this self-similar solution is questionable from the physical point of view, as the two lateral jets plunge onto the free surface, leading to a self-intersecting flow. The physical mechanism leading to the formation of the mushroom-shaped structure is discussed.

scholarly journals Three-Dimensional Motion of Tennis Ball

2021 ◽  
Vol 1 (1) ◽  
pp. 57-68
Author(s):  
Anastas Ivanov ◽  
Keyword(s):  
Three Dimensional ◽  
Initial Position ◽  
Linear Velocity ◽  
Point Of View ◽  
Tennis Ball ◽  
Physical Point ◽  
Tennis Players ◽  
Advantages And Disadvantages ◽  
Bottom Side ◽  
The Way

Modern tennis players use a variety of strokes. From the physical point of view, these shots can be classified into eight main groups depending on the way the racket interacts with the tennis ball. These are strokes with top, bottom, side, top-side, and bottom-side rotation, as well as strokes without rotation. These eight interactions lead to eight main types of trajectories at the same initial position and the same initial linear velocity. The main purpose of the study is to determine these trajectories and to describe their advantages and disadvantages in modern competitive tennis. The calculations and graphical images are performed with the MatLab mathematical package

GROUNDWATER TIME SERIES

1970 ◽  
Vol 1 (3) ◽  
pp. 181-205 ◽  
Author(s):  
ERIK ERIKSSON
Keyword(s):  
Time Series ◽  
Point Of View ◽  
Hydrologic Models ◽  
Physical Point ◽  
Run Off ◽  
Fort Collins ◽  
Statistical Sense ◽  
Full Benefit ◽  
Future Work ◽  
Prediction Problems

The term “stochastic hydrology” implies a statistical approach to hydrologic problems as opposed to classic hydrology which can be considered deterministic in its approach. During the International Hydrology Symposium, held 6-8 September 1967 at Fort Collins, a number of hydrology papers were presented consisting to a large extent of studies on long records of hydrological elements such as river run-off, these being treated as time series in the statistical sense. This approach is, no doubt, of importance for future work especially in relation to prediction problems, and there seems to be no fundamental difficulty for introducing the stochastic concepts into various hydrologic models. There is, however, some developmental work required – not to speak of educational in respect to hydrologists – before the full benefit of the technique is obtained. The present paper is to some extent an exercise in the statistical study of hydrological time series – far from complete – and to some extent an effort to interpret certain features of such time series from a physical point of view. The material used is 30 years of groundwater level observations in an esker south of Uppsala, the observations being discussed recently by Hallgren & Sands-borg (1968).

scholarly journals Percolation and tortuosity in heart-like cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
R. Rabinovitch ◽  
Y. Biton ◽  
D. Braunstein ◽  
I. Aviram ◽  
R. Thieberger ◽  
...  
Keyword(s):  
Action Potential ◽  
Forest Fire ◽  
Sinus Node ◽  
Heart Tissue ◽  
Point Of View ◽  
Physical Point ◽  
Electrical Currents ◽  
Single Wave ◽  
Heart Arrhythmia ◽  
The One

AbstractIn the last several years, quite a few papers on the joint question of transport, tortuosity and percolation have appeared in the literature, dealing with passage of miscellaneous liquids or electrical currents in different media. However, these methods have not been applied to the passage of action potential in heart fibrosis (HF), which is crucial for problems of heart arrhythmia, especially of atrial tachycardia and fibrillation. In this work we address the HF problem from these aspects. A cellular automaton model is used to analyze percolation and transport of a distributed-fibrosis inflicted heart-like tissue. Although based on a rather simple mathematical model, it leads to several important outcomes: (1) It is shown that, for a single wave front (as the one emanated by the heart's sinus node), the percolation of heart-like matrices is exactly similar to the forest fire case. (2) It is shown that, on the average, the shape of the transport (a question not dealt with in relation to forest fire, and deals with the delay of action potential when passing a fibrotic tissue) behaves like a Gaussian. (3) Moreover, it is shown that close to the percolation threshold the parameters of this Gaussian behave in a critical way. From the physical point of view, these three results are an important contribution to the general percolation investigation. The relevance of our results to cardiological issues, specifically to the question of reentry initiation, are discussed and it is shown that: (A) Without an ectopic source and under a mere sinus node operation, no arrhythmia is generated, and (B) A sufficiently high refractory period could prevent some reentry mechanisms, even in partially fibrotic heart tissue.

Comparison of the reluctance laminated and solid rotor synchronous machine operating at high temperatures

2019 ◽  
Vol 38 (4) ◽  
pp. 1111-1119 ◽  
Author(s):  
Marcin Lefik ◽  
Krzysztof Komeza ◽  
Ewa Napieralska-Juszczak ◽  
Daniel Roger ◽  
Piotr Andrzej Napieralski
Keyword(s):  
High Speed ◽  
Design Methodology ◽  
Three Dimensional ◽  
Synchronous Machine ◽  
Point Of View ◽  
Heat Sources ◽  
Model Calculations ◽  
Content Type ◽  
Thermal Phenomenon ◽  
Practical Implications

Purpose The purpose of this paper is to present a comparison between reluctance synchronous machine-enabling work at high internal temperature (HT° machine) with laminated and solid rotor. Design/methodology/approach To obtain heat sources for the thermal model, calculations of the electromagnetic field were made using the Opera 3D program including effect of rotation and the resulting eddy current losses. To analyse the thermal phenomenon, the 3D coupled thermal-fluid (CFD) model is used. Findings The presented results show clearly that laminated construction is much better from a point of view of efficiency and temperature. However, solid construction can be interesting for high speed machines due to their mechanical robustness. Research limitations/implications The main problem, despite the use of parallel calculations, is the long calculation time. Practical implications The obtained simulation and experimental results show the possibility of building a machine operating at a much higher ambient temperature than it was previously produced for example in the vicinity of the aircraft turbines. Originality/value The paper presents the application of fully three-dimensional coupled electromagnetic and thermal analysis of new machine constructions designed for elevated temperature.

Cyclopean Vision, Size Estimation, and Presence in Orthostereoscopic Images

2001 ◽  
Vol 10 (3) ◽  
pp. 312-330 ◽  
Author(s):  
Bernard Harper ◽  
Richard Latto
Keyword(s):  
Visual System ◽  
Three Dimensional ◽  
Point Of View ◽  
Psychophysical Experiment ◽  
Size Estimation ◽  
Human Form ◽  
Image Capture ◽  
Series Of Experiments ◽  
Abstract Shapes ◽  
And Control

Stereo scene capture and generation is an important facet of presence research in that stereoscopic images have been linked to naturalness as a component of reported presence. Three-dimensional images can be captured and presented in many ways, but it is rare that the most simple and “natural” method is used: full orthostereoscopic image capture and projection. This technique mimics as closely as possible the geometry of the human visual system and uses convergent axis stereography with the cameras separated by the human interocular distance. It simulates human viewing angles, magnification, and convergences so that the point of zero disparity in the captured scene is reproduced without disparity in the display. In a series of experiments, we have used this technique to investigate body image distortion in photographic images. Three psychophysical experiments compared size, weight, or shape estimations (perceived waist-hip ratio) in 2-D and 3-D images for the human form and real or virtual abstract shapes. In all cases, there was a relative slimming effect of binocular disparity. A well-known photographic distortion is the perspective flattening effect of telephoto lenses. A fourth psychophysical experiment using photographic portraits taken at different distances found a fattening effect with telephoto lenses and a slimming effect with wide-angle lenses. We conclude that, where possible, photographic inputs to the visual system should allow it to generate the cyclopean point of view by which we normally see the world. This is best achieved by viewing images made with full orthostereoscopic capture and display geometry. The technique can result in more-accurate estimations of object shape or size and control of ocular suppression. These are assets that have particular utility in the generation of realistic virtual environments.

scholarly journals Focal transformation, an imaging concept for signal restoration and noise removal

Geophysics ◽  
2006 ◽  
Vol 71 (6) ◽  
pp. A55-A59 ◽  
Author(s):  
A. J. Berkhout ◽  
D. J. Verschuur
Keyword(s):  
Input Data ◽  
Noise Removal ◽  
Point Of View ◽  
Data Interpolation ◽  
Signal Restoration ◽  
Physical Point ◽  
Seismic Processing ◽  
Promising Tool ◽  
Focal Area ◽  
Forward Operator

Interpolation of data beyond aliasing limits and removal of noise that occurs within the seismic bandwidth are still important problems in seismic processing. The focal transform is introduced as a promising tool in data interpolation and noise removal, allowing the incorporation of macroinformation about the involved wavefields. From a physical point of view, the principal action of the forward focal operator is removing the spatial phase of the signal content from the input data, and the inverse focal operator restores what the forward operator has removed. The strength of the method is that in the transformed domain, the focused signals at the focal area can be separated from the dispersed noise away from the focal area. Applications of particular interest in preprocessing are interpolation of missing offsets and reconstruction of signal beyond aliasing. The latter can be seen as the removal of aliasing noise.

scholarly journals Cell Bioprinting: The 3D-Bioplotter™ Case

Materials ◽  
2019 ◽  
Vol 12 (23) ◽  
pp. 4005 ◽  
Author(s):  
Angelats Lobo ◽  
Ginestra
Keyword(s):  
3D Structure ◽  
Three Dimensional ◽  
Petri Dish ◽  
Two Dimensions ◽  
Point Of View ◽  
Lack Of Information ◽  
Synthetic Materials ◽  
Different Types ◽  
Available Information ◽  
User Friendly

The classic cell culture involves the use of support in two dimensions, such as a well plate or a Petri dish, that allows the culture of different types of cells. However, this technique does not mimic the natural microenvironment where the cells are exposed to. To solve that, three-dimensional bioprinting techniques were implemented, which involves the use of biopolymers and/or synthetic materials and cells. Because of a lack of information between data sources, the objective of this review paper is, to sum up, all the available information on the topic of bioprinting and to help researchers with the problematics with 3D bioprinters, such as the 3D-Bioplotter™. The 3D-Bioplotter™ has been used in the pre-clinical field since 2000 and could allow the printing of more than one material at the same time, and therefore to increase the complexity of the 3D structure manufactured. It is also very precise with maximum flexibility and a user-friendly and stable software that allows the optimization of the bioprinting process on the technological point of view. Different applications have resulted from the research on this field, mainly focused on regenerative medicine, but the lack of information and/or the possible misunderstandings between papers makes the reproducibility of the tests difficult. Nowadays, the 3D Bioprinting is evolving into another technology called 4D Bioprinting, which promises to be the next step in the bioprinting field and might promote great applications in the future.

Engineering Analysis of Shoulder Dystocia in the Human Birth Process by the Finite Element Method

1992 ◽  
Vol 206 (4) ◽  
pp. 243-250 ◽  
Author(s):  
A Meghdari ◽  
R Davoodi ◽  
F Mesbah
Keyword(s):  
Finite Element ◽  
Three Dimensional ◽  
Shoulder Dystocia ◽  
Point Of View ◽  
Engineering Analysis ◽  
The Finite Element Method ◽  
Birth Process ◽  
Beam Elements ◽  
Finite Element Package ◽  
Human Birth

This paper presents an engineering analysis of shoulder dystocia (SD) in the human birth process which usually results in damaging the brachial plexus nerves and the humerus and/or clavicle bones of the baby. The goal is to study these injuries from the mechanical engineering point of view. Two separate finite element models of the neonatal neck and the clavicle bone have been simulated using eight-node three-dimensional elements and beam elements respectively. Simulated models have been analysed under suitable boundary conditions using the ‘SAP80’ finite element package. Finally, results obtained have been verified by comparing them with published clinical and experimental observations.

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