scholarly journals Chemical approaches for profiling dynamic palmitoylation

2013 ◽  
Vol 41 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Brent R. Martin
Keyword(s):  
Global Analysis ◽  
Present Review ◽  
Post Translational Modification ◽  
Enzymatic Regulation ◽  
Protein Palmitoylation ◽  
Future Challenges ◽  
Selective Chemical ◽  
Cellular Pathways ◽  
Membrane Compartmentalization ◽  
The Impact

Protein palmitoylation is a critical post-translational modification important for membrane compartmentalization, trafficking and regulation of many key signalling proteins. Recent non-radioactive chemo-proteomic labelling methods have enabled a new focus on this emerging regulatory modification. Palmitoylated proteins can now be profiled in complex biological systems by MS for direct annotation and quantification. Based on these analyses, palmitoylation is clearly widespread and broadly influences the function of many cellular pathways. The recent introduction of selective chemical labelling approaches has opened new opportunities to revisit long-held questions about the enzymatic regulation of this widespread post-translational modification. In the present review, we discuss the impact of new chemical labelling approaches and future challenges for the dynamic global analysis of protein palmitoylation.

O-GlcNAc transferase inhibitors: current tools and future challenges

2016 ◽  
Vol 44 (1) ◽  
pp. 88-93 ◽  
Author(s):  
Riccardo Trapannone ◽  
Karim Rafie ◽  
Daan M.F. van Aalten
Keyword(s):  
Animal Models ◽  
Biological Systems ◽  
Biological Role ◽  
Present Review ◽  
Biological Functions ◽  
Post Translational Modification ◽  
Embryonic Lethal ◽  
Future Challenges ◽  
Glcnac Transferase

The O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification (O-GlcNAcylation) is the dynamic and reversible attachment of N-acetylglucosamine to serine and threonine residues of nucleocytoplasmic target proteins. It is abundant in metazoa, involving hundreds of proteins linked to a plethora of biological functions with implications in human diseases. The process is catalysed by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that add and remove sugar moieties respectively. OGT knockout is embryonic lethal in a range of animal models, hampering the study of the biological role of O-GlcNAc and the dissection of catalytic compared with non-catalytic roles of OGT. Therefore, selective and potent chemical tools are necessary to inhibit OGT activity in the context of biological systems. The present review focuses on the available OGT inhibitors and summarizes advantages, limitations and future challenges.

Perception of Professionals towards Effectiveness of Human Resource Information System

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Bharti Motwani
Keyword(s):  
Information System ◽  
Human Resource ◽  
Training Programme ◽  
Middle Level ◽  
Human Beings ◽  
Human Resource Information System ◽  
Resource Information ◽  
Future Challenges ◽  
Operational Decision Making ◽  
The Impact

Organizations are facing stiff market and other external pulls and pushes, thus HR will become vital source for managing future challenges. HRIS is an information system that makes use of computers to monitor, control, and influence the movement of human beings from the time they indicate their intention to join an organization till the time they separate from it. The purpose of the HRIS is to provide service, in the form of accurate and timely information, to the clients of the system. As there are a variety of potential users of HR information, it may be used for strategic, tactical, and operational decision making (e.g., to plan for needed professionals in a merger), to avoid litigation (e.g., to identify discrimination problems in hiring), to evaluate programmes, policies, or practices (e.g., to evaluate the effectiveness of a training programme), and/or to support daily operations (e.g., to help managers monitor time and attendance of their professionals). However, in order to maximize HRIS success, researchers and practitioners have to know more about its underlying drivers. The study is undertaken looking to the importance of HRIS in the organizations. The paper identifies the factors of HRIS as perceived by professional users. This study is also an attempt to study the impact of designation on identified factors of Human Resource Information System (HRIS). The results of this research will increase researchers comprehension on difference in factors that influence effectiveness of senior and middle-level professionals.

scholarly journals A global analysis of the impact of COVID-19 stay-at-home restrictions on crime

2021 ◽  
Author(s):  
Amy E. Nivette ◽  
Renee Zahnow ◽  
Raul Aguilar ◽  
Andri Ahven ◽  
Shai Amram ◽  
...  
Keyword(s):  
Public Space ◽  
Global Analysis ◽  
Sudden Change ◽  
Interrupted Time Series ◽  
Urban Crime ◽  
Substantial Variation ◽  
Different Types ◽  
Time Series Analyses ◽  
The Impact ◽  
At Home

AbstractThe stay-at-home restrictions to control the spread of COVID-19 led to unparalleled sudden change in daily life, but it is unclear how they affected urban crime globally. We collected data on daily counts of crime in 27 cities across 23 countries in the Americas, Europe, the Middle East and Asia. We conducted interrupted time series analyses to assess the impact of stay-at-home restrictions on different types of crime in each city. Our findings show that the stay-at-home policies were associated with a considerable drop in urban crime, but with substantial variation across cities and types of crime. Meta-regression results showed that more stringent restrictions over movement in public space were predictive of larger declines in crime.

scholarly journals Global analysis of the Sivers functions at NLO+NNLL in QCD

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Miguel G. Echevarria ◽  
Zhong-Bo Kang ◽  
John Terry
Keyword(s):  
Pair Production ◽  
Global Analysis ◽  
Vector Boson ◽  
Lepton Pair ◽  
Transverse Spin ◽  
Dglap Evolution ◽  
Spin Asymmetries ◽  
Lepton Pair Production ◽  
Asymmetry Data ◽  
The Impact

Abstract We perform global fit to the quark Sivers function within the transverse momentum dependent (TMD) factorization formalism in QCD. We simultaneously fit Sivers asymmetry data from Semi-Inclusive Deep Inelastic Scattering (SIDIS) at COMPASS, HERMES, and JLab, from Drell-Yan lepton pair production at COMPASS, and from W/Z boson at RHIC. This extraction is performed at next-to-leading order (NLO) and next-to-next-to leading logarithmic (NNLL) accuracy. We find excellent agreement between our extracted asymmetry and the experimental data for SIDIS and Drell-Yan lepton pair production, while tension arises when trying to describe the spin asymmetries of W/Z bosons at RHIC. We carefully assess the situation, and we study in details the impact of the RHIC data and their implications through different ways of performing the fit. In addition, we find that the quality of the description of W/Z vector boson asymmetry data could be strongly sensitive to the DGLAP evolution of Qiu-Sterman function, besides the usual TMD evolution. We present discussion on this and the implications for measurements of the transverse-spin asymmetries at the future Electron Ion Collider.

scholarly journals Decision-Making Processes in Controlling Exposure to Sunlight Supported by Simulation Tools: A Case Study in Warm Weather

Energies ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 4100
Author(s):  
Mariana Huskinson ◽  
Antonio Galiano-Garrigós ◽  
Ángel Benigno González-Avilés ◽  
M. Isabel Pérez-Millán
Keyword(s):  
Decision Making ◽  
Global Analysis ◽  
Energy Performance ◽  
Information Modeling ◽  
The European Union ◽  
Evaluation Tool ◽  
Simulation Tools ◽  
Building Information ◽  
The Impact

Improving the energy performance of existing buildings is one of the main strategies defined by the European Union to reduce global energy costs. Amongst the actions to be carried out in buildings to achieve this objective is working with passive measures adapted to each type of climate. To assist designers in the process of finding appropriate solutions for each building and location, different tools have been developed and since the implementation of building information modeling (BIM), it has been possible to perform an analysis of a building’s life cycle from an energy perspective and other types of analysis such as a comfort analysis. In the case of Spain, the first BIM environment tool has been implemented that deals with the global analysis of a building’s behavior and serves as an alternative to previous methods characterized by their lack of both flexibility and information offered to designers. This paper evaluates and compares the official Spanish energy performance evaluation tool (Cypetherm) released in 2018 using a case study involving the installation of sunlight control devices as part of a building refurbishment. It is intended to determine how databases and simplifications affect the designer’s decision-making. Additionally, the yielded energy results are complemented by a comfort analysis to explore the impact of these improvements from a users’ wellbeing viewpoint. At the end of the process the yielded results still confirm that the simulation remains far from reality and that simulation tools can indeed influence the decision-making process.

scholarly journals The Protein Interactome of Glycolysis in Escherichia coli

Proteomes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 16
Author(s):  
Shomeek Chowdhury ◽  
Stephen Hepper ◽  
Mudassir K. Lodi ◽  
Milton H. Saier ◽  
Peter Uetz
Keyword(s):  
Escherichia Coli ◽  
Protein Interactions ◽  
Allosteric Regulation ◽  
Glycolytic Enzymes ◽  
Protein Protein Interactions ◽  
Post Translational Modification ◽  
Interacting Protein ◽  
E Coli ◽  
Protein Interactome ◽  
The Impact

Glycolysis is regulated by numerous mechanisms including allosteric regulation, post-translational modification or protein-protein interactions (PPI). While glycolytic enzymes have been found to interact with hundreds of proteins, the impact of only some of these PPIs on glycolysis is well understood. Here we investigate which of these interactions may affect glycolysis in E. coli and possibly across numerous other bacteria, based on the stoichiometry of interacting protein pairs (from proteomic studies) and their conservation across bacteria. We present a list of 339 protein-protein interactions involving glycolytic enzymes but predict that ~70% of glycolytic interactors are not present in adequate amounts to have a significant impact on glycolysis. Finally, we identify a conserved but uncharacterized subset of interactions that are likely to affect glycolysis and deserve further study.

Public Sector Employment, Quality of Government, and Well-Being: A Global Analysis

2021 ◽  
pp. 223386592110117
Author(s):  
Robert Davidson ◽  
Alexander Pacek ◽  
Benjamin Radcliff
Keyword(s):  
Public Sector ◽  
Global Analysis ◽  
Well Being ◽  
Subjective Well Being ◽  
Cross Sectional ◽  
Political Factors ◽  
The Public ◽  
Employment Quality ◽  
The Impact

While a growing literature within the study of subjective well-being demonstrates the impact of socio-political factors on subjective well-being, scholars have conspicuously failed to consider the role of the size and scope of government as determinants of well-being. Where such studies exist, the focus is largely on the advanced industrial democracies of the Organization for Economic Co-Operation and Development. In this study, we examine the size of the public sector as a determinant of cross-national variation in life satisfaction across a worldwide sample. Our findings strongly suggest that as the public sector grows, subjective well-being increases as well, conditional on the extent of quality of government. Using cross-sectional data on 84 countries, we show this relationship has an independent and separable impact from other economic and political factors.

Annual review of research

2003 ◽  
Vol 36 (3) ◽  
pp. 165-189 ◽  
Author(s):  
Richard Johnstone
Keyword(s):  
Information And Communications Technology ◽  
Present Review ◽  
Annual Review ◽  
Communications Technology ◽  
Pedagogical Practice ◽  
Separate Section ◽  
Important Trend ◽  
The Impact

The present review refers to studies published in 2002 in leading research journals. It focuses in particular on learning, teaching and policy in respect of second, modern foreign or additional languages. The comments offered about particular studies are not intended to summarise them (for that, it is best to refer to the actual abstracts which the present journal publishes). What is on offer is a personal selection made because some aspect of a particular article seemed to be of particular interest or to reflect an important trend, and I have attempted to link such elements together to form a narrative. Compared with previous years, two important themes seemed to gather particular momentum in 2002: first, the role of ‘frequency’ in acquisition; and second, the impact of complex and contradictory global factors on everyday pedagogical practice, thinking and attitudes. As in previous years reference is made to the abstracts. Thus, Tarone (2002: 03-158) refers to an article by Tarone published in 2002 and reflected in the 2003 series of this journal as abstract 158. In previous years I have discussed ICT (information and communications technology) in a separate section of its own but this has now been integrated into other sections, reflecting a process of ‘normalisation’.

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