scholarly journals Role of splice variants in the metastatic progression of prostate cancer

2012 ◽  
Vol 40 (4) ◽  
pp. 870-874 ◽  
Author(s):  
Rachel M. Hagen ◽  
Michael R. Ladomery
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Splice Variants ◽  
Human Cancer ◽  
Metastatic Potential ◽  
Metastatic Progression ◽  
Cellular Phenotype ◽  
Prostate Cancer Metastasis ◽  
The Relationship

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into the relationship between altered AS of key genes and the initiation of prostate cancer metastasis.

scholarly journals Role of exosomal small RNA in prostate cancer metastasis

2018 ◽  
Vol Volume 10 ◽  
pp. 4029-4038 ◽  
Author(s):  
Fei Zhan ◽  
Jingling Shen ◽  
Ruitao Wang ◽  
Liang Wang ◽  
Yao Dai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Rna ◽  
Cancer Metastasis ◽  
Prostate Cancer Metastasis

scholarly journals New insights into the role of CXCR4 in prostate cancer metastasis

2008 ◽  
Vol 7 (11) ◽  
pp. 1849-1851 ◽  
Author(s):  
Candece L. Gladson ◽  
Danny R. Welch
Keyword(s):  
Prostate Cancer ◽  
Cancer Metastasis ◽  
Prostate Cancer Metastasis

scholarly journals Crosstalk between Prostate Cancer Cells and Tumor-Associated Fibroblasts Enhances the Malignancy by Inhibiting the Tumor Suppressor PLZF

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1083
Author(s):  
Kum Hee Noh ◽  
Ae Jin Jeong ◽  
Haeri Lee ◽  
Song-Hee Lee ◽  
Eunhee Yi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Tyrosine Phosphatase ◽  
Migration And Invasion ◽  
Metastatic Progression ◽  
Prostate Cancer Cells ◽  
Prostate Cancer Metastasis

Although prostate cancer is clinically manageable during the early stages of progression, metastatic progression severely compromises the prognosis and leads to mortality. Constitutive activation of STAT3 has been connected to prostate cancer malignancy, and abolishing the STAT3 activity may diminish tumor growth and metastasis. However, its suppressor genes and pathways have not been well established. In this study, we show that promyelocytic leukemia zinc finger (PLZF) has a putative tumor-suppressor function in prostate cancer by inhibiting phosphorylation of STAT3. Compared with a benign prostate, high-grade prostate cancer patient tissue was negatively correlated with PLZF expression. PLZF depletion accelerated proliferation and survival, migration, and invasion in human prostate cancer cells. Mechanistically, we demonstrated a novel role of PLZF as the transcriptional regulator of the tyrosine phosphatase SHP-1 that inhibits the oncogenic JAKs–STAT3 pathway. These results suggest that the collapse of PLZF expression by the CCL3 derived from fibroblasts accelerates the cell migration and invasion properties of prostate cancer cells. Our results suggest that increasing PLZF could be an attractive strategy for suppressing prostate cancer metastasis as well as for tumor growth.

scholarly journals Role of αVβ3 in Prostate Cancer: Metastasis Initiator and Important Therapeutic Target

2020 ◽  
Vol Volume 13 ◽  
pp. 7411-7422 ◽  
Author(s):  
Lin Tang ◽  
Meng Xu ◽  
Long Zhang ◽  
Lin Qu ◽  
Xiaoyan Liu
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Cancer Metastasis ◽  
Prostate Cancer Metastasis ◽  
Important Therapeutic Target
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