Catalysis by the nucleolytic ribozymes

2011 ◽  
Vol 39 (2) ◽  
pp. 641-646 ◽  
Author(s):  
David M.J. Lilley
Keyword(s):  
Base Catalysis ◽  
Hairpin Ribozyme ◽  
Cleavage Reaction ◽  
Acid Base ◽  
Rate Enhancement ◽  
General Base ◽  
General Acid ◽  
Varkud Satellite Ribozyme

The nucleolytic ribozymes use general acid–base catalysis to contribute significantly to their rate enhancement. The VS (Varkud satellite) ribozyme uses a guanine and an adenine nucleobase as general base and acid respectively in the cleavage reaction. The hairpin ribozyme is probably closely similar, while the remaining nucleolytic ribozymes provide some interesting contrasts.

scholarly journals General Acid–Base Catalysis Mediated by Nucleobases in the Hairpin Ribozyme

2012 ◽  
Vol 134 (40) ◽  
pp. 16717-16724 ◽  
Author(s):  
Stephanie Kath-Schorr ◽  
Timothy J. Wilson ◽  
Nan-Sheng Li ◽  
Jun Lu ◽  
Joseph A. Piccirilli ◽  
...  
Keyword(s):  
Base Catalysis ◽  
Hairpin Ribozyme ◽  
Acid Base ◽  
General Acid

scholarly journals Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme

2010 ◽  
Vol 107 (26) ◽  
pp. 11751-11756 ◽  
Author(s):  
T. J. Wilson ◽  
N.-S. Li ◽  
J. Lu ◽  
J. K. Frederiksen ◽  
J. A. Piccirilli ◽  
...  
Keyword(s):  
Base Catalysis ◽  
Acid Base ◽  
General Acid ◽  
Varkud Satellite Ribozyme
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