The role of the Wilms' tumour-suppressor protein WT1 in apoptosis

2008 ◽  
Vol 36 (4) ◽  
pp. 629-631 ◽  
Author(s):  
Jörg Hartkamp ◽  
Stefan G.E. Roberts
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Wilms Tumour ◽  
Zinc Finger Transcription Factor ◽  
Tumour Suppressor Protein ◽  
Proliferation And Apoptosis

The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.

scholarly journals ROLE OF TUMOUR SUPPRESSOR GENE P53 IN TRIPLE NEGATIVE BREAST CANCER

2017 ◽  
Vol 5 (4.2) ◽  
pp. 4585-4589
Author(s):  
Priya S Patil ◽  
◽  
Jaydeep N Pol ◽  
Ashalata D Patil ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1

Gene ◽  
1995 ◽  
Vol 167 (1-2) ◽  
pp. 239-243 ◽  
Author(s):  
Andrew Ward ◽  
Jo-Anna Pooler ◽  
Kiyoshi Miyagawa ◽  
Antonio Duarte ◽  
Nicholas D. Hastie ◽  
...  
Keyword(s):  
Growth Factor ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Insulin Like Growth Factor ◽  
Wilms Tumour ◽  
Factor Ii ◽  
Encoding Gene ◽  
By Products

scholarly journals Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2

Oncogene ◽  
1997 ◽  
Vol 14 (22) ◽  
pp. 2689-2700 ◽  
Author(s):  
Melanie J McConnell ◽  
Heather E Cunliffe ◽  
Lin J Chua ◽  
Teresa A Ward ◽  
Michael R Eccles
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Differential Regulation ◽  
Tumour Suppressor ◽  
Wilms Tumour

Essential Role of Kindlin 3 in Zebrafish Thrombopoiesis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1166-1166
Author(s):  
James J. Mann ◽  
Nathaniel B. Langer ◽  
Andrew Woo ◽  
Tyler B. Moran ◽  
Yocheved Schindler ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Essential Role ◽  
Molecular Mechanisms ◽  
Fetal Liver ◽  
Affinity Purification ◽  
Transgenic Zebrafish ◽  
Zinc Finger Transcription Factor ◽  
Stage Of Development

Abstract The zinc finger transcription factor GATA-1 is required for proliferative inhibition and terminal maturation of megakaryocytes, and is mutated in Down Syndrome Transient Myeloproliferative Disorder (TMD) and Acute Megakaryoblastic Leukemia (DS-AMKL). Yet the molecular mechanisms that regulate GATA-1 activity in megakaryopoiesis remain incompletely understood. Many transcription factors, in addition to binding DNA, make important protein-protein interactions that modulate their activity. In order to further understand GATA-1’s function, and possibly identify new factors involved in megakaryopoiesis, we purified GATA-1 containing multiprotein complexes from the murine L8057 megakaryocytic cell line. We generated stable L8057 cell lines expressing metabolically biotinylated and FLAG epitope tagged GATA-1, and then performed a tandem anti-FLAG immunoaffinity and streptavidin affinity purification. Using mass spectrometry (LC/MS/MS), we identified the known GATA-1 associated proteins Friend of GATA-1 (FOG-1), SCL, Ldb1, Runx-1/Cbf-β. SP1 and all components of the NuRD complex (which binds FOG-1) as co-purifying proteins. In addition, we reproducibly obtained several novel proteins. We previously reported the identification of the kruppel-type zinc finger transcription factor zfp148 (also called ZBP-89), and showed that it plays an essential role in megakaryopoiesis and definitive erythropoiesis. Here we report the identification of Kindlin 3 (also called URP2 for UNC-112 related protein 2), a member of a family of PH and FERM domain containing proteins that are thought to play a role in integrin-mediated processes. Expression of Kindlin 3 is restricted to hematopoietic cells, principally megakaryocytes and lymphocytes. It is first expressed at ~E9.5 during murine embryogenesis, and is abundant in fetal liver megakaryocytes by day E14.5. In order to begin to assess the role of Kindlin 3 in megakaryopoiesis in vivo, we performed morpholino-mediated knockdown of Kindlin 3 expression in CD41-GFP transgenic zebrafish embryos. In contrast to control embryos, embryos injected with Kindlin 3 specific morpholinos exhibited nearly complete loss of GFP+ thrombocytes (equivalent to mammalian megakaryocyte/platelets). Erythroid development (equivalent to mammalian primitive erythropoiesis at this stage of development) was not significantly affected, similar to embryos injected with zfp148-specific morpholinos. Given the role of integrin outside-to-inside signaling in megakaryopoiesis, we propose that Kindlin 3 may play a role linking extracellular signals to megakaryocyte maturation and growth control via GATA-1 transcription complexes. Further analysis in murine systems is underway to test this hypothesis.

scholarly journals Role of the Zinc Finger Transcription Factor SltA in Morphogenesis and Sterigmatocystin Biosynthesis in the Fungus Aspergillus nidulans

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68492 ◽  
Author(s):  
Sourabha Shantappa ◽  
Sourabh Dhingra ◽  
Patricia Hernández-Ortiz ◽  
Eduardo A. Espeso ◽  
Ana M. Calvo
Keyword(s):  
Transcription Factor ◽  
Aspergillus Nidulans ◽  
Zinc Finger ◽  
Zinc Finger Transcription Factor

scholarly journals Role of Epiprofin, a zinc-finger transcription factor, in limb development

2010 ◽  
Vol 337 (2) ◽  
pp. 363-374 ◽  
Author(s):  
Ana Talamillo ◽  
Irene Delgado ◽  
Takashi Nakamura ◽  
Susana de-Vega ◽  
Yasuo Yoshitomi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Limb Development ◽  
Zinc Finger Transcription Factor
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