Evolution of insect P450

2006 ◽  
Vol 34 (6) ◽  
pp. 1252-1255 ◽  
Author(s):  
R. Feyereisen
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Insect Genome ◽  
Physiological Functions ◽  
Environmental Challenges

The first fully sequenced insect genomes were those of the fruitfly and the mosquito, both from the order Diptera. Now, with an increasing number and diversity of insect genomes becoming available, the diversity of insect P450 genes can be better appreciated and tentative ideas about the evolution of the CYP (cytochrome P450) superfamily in insects can be proposed. There are four large clades of insect P450 genes that existed before the divergence of the class Insecta and that are also represented by CYP families in vertebrates: the CYP2 clade, the CYP3 clade, the CYP4 clade and the mitochondrial P450 clade. P450s with known or suspected physiological functions are present in each of these clades and only a dozen genes appear to have orthologues or very close paralogues in each insect genome. P450 enzymes from each of these clades have been linked to insecticide resistance or to the metabolism of natural products and xenobiotics. In particular, insects appear to maintain a repertoire of mitochondrial P450 paralogues devoted to the response to environmental challenges.

NocU is a Cytochrome P450 Oxygenase Catalyzing N-Hydroxylation of the Indolic Moiety during the Maturation of the Thiopeptide Antibiotics Nocathiacins

2021 ◽  
Author(s):  
Heng Guo ◽  
Xuebing Bai ◽  
Qian Yang ◽  
Yufeng Xue ◽  
Dandan Chen ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
The Family ◽  
Thiopeptide Antibiotics

The ribosomally synthesized and post-translationally modified peptide (RiPP) natural products include the family of thiopeptide antibiotics, where nocathiacins (NOCs) and nosiheptide (NOS) are structurally related bicyclic members featuring an indolic...

DETOXICATIVE ENZYME ACTIVITIES IN FIVE SPECIES OF FIELD-COLLECTED MELANOPLINE GRASSHOPPERS (ORTHOPTERA: ACRIDIDAE)

1996 ◽  
Vol 128 (2) ◽  
pp. 353-354 ◽  
Author(s):  
Murray B. Isman ◽  
Ruying Feng ◽  
Dan L. Johnson
Keyword(s):  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Host Plant ◽  
Enzyme Activities ◽  
Cytochrome P450 Monooxygenases ◽  
Insect Host ◽  
Suitable Host ◽  
P450 Monooxygenases ◽  
Enzyme Systems ◽  
General Esterases

Detoxicative enzyme systems, such as the cytochrome P450 monooxygenases, gluthione S-transferases, and general esterases, have been widely studied in holometabolous insects (e.g. Lepidoptera, Diptera, and Coleoptera). These, and other enzyme systems, play important roles in insecticide resistance, but are also important in insect–host plant relationships, because host range can partially depend on the ability of an insect to cope with putatively toxic allelochemicals in an otherwise suitable host plant (e.g. Lindroth 1989). In some cases, differences in the relative activities of these enzymes between closely related insect taxa can have significant biological consequences (Siegfried and Mullin 1989).

Microarray analysis of cytochrome P450 mediated insecticide resistance in Drosophila

2003 ◽  
Vol 33 (7) ◽  
pp. 701-708 ◽  
Author(s):  
G. Le Goff ◽  
S. Boundy ◽  
P.J. Daborn ◽  
J.L. Yen ◽  
L. Sofer ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Insecticide Resistance ◽  
Microarray Analysis

Mechanism-based inactivation of cytochrome P450 enzymes by natural products based on metabolic activation

2020 ◽  
Vol 52 (4) ◽  
pp. 501-530
Author(s):  
Tingting Zhang ◽  
Jinqiu Rao ◽  
Wei Li ◽  
Kai Wang ◽  
Feng Qiu
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Metabolic Activation ◽  
Cytochrome P450 Enzymes

scholarly journals Monitoring Insecticide Susceptibility in Aedes Aegypti Populations from the Two Biggest Cities, Ouagadougou and Bobo-Dioulasso, in Burkina Faso: Implication of Metabolic Resistance

2020 ◽  
Vol 5 (2) ◽  
pp. 84
Author(s):  
Moussa Namountougou ◽  
Dieudonné Diloma Soma ◽  
Mahamoudou Balboné ◽  
Didier Alexandre Kaboré ◽  
Mahamadi Kientega ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aedes Aegypti ◽  
West Africa ◽  
Insecticide Resistance ◽  
Burkina Faso ◽  
Urban Areas ◽  
Mortality Rates ◽  
Metabolic Resistance ◽  
Bobo Dioulasso ◽  
Glutathione S Transferases

In West Africa, Aedes aegypti remains the major vector of dengue virus. Since 2013, dengue fever has been reemerging in Burkina Faso with annual outbreaks, thus becoming a major public health problem. Its control relies on vector control, which is unfortunately facing the problem of insecticide resistance. At the time of this study, although data on phenotypic resistance were available, information related to the metabolic resistance in Aedes populations from Burkina Faso remained very scarce. Here, we assessed the phenotypic and the metabolic resistance of Ae. aegypti populations sampled from the two main urban areas (Ouagadougou and Bobo-Dioulasso) of Burkina Faso. Insecticide susceptibility bioassays to chlorpyriphos-methyl 0.4%, bendiocarb 0.1% and deltamethrin 0.05% were performed on natural populations of Ae. aegypti using the WHO protocol. The activity of enzymes involved in the rapid detoxification of insecticides, especially non-specific esterases, oxidases (cytochrome P450) and glutathione-S-transferases, was measured on individual mosquitos. The mortality rates for deltamethrin 0.05% were low and ranged from 20.72% to 89.62% in the Bobo-Dioulasso and Ouagadougou sites, respectively. When bendiocarb 0.1% was tested, the mortality rates ranged from 7.73% to 71.23%. Interestingly, in the two urban areas, mosquitoes were found to be fully susceptible to chlorpyriphos-methyl 0.4%. Elevated activity of non-specific esterases and glutathione-S-transferases was reported, suggesting multiple resistance mechanisms involved in Ae. aegypti populations from Bobo-Dioulasso and Ouagadougou (including cytochrome P450). This update to the insecticide resistance status within Ae. aegypti populations in the two biggest cities is important to better plan dengue vectors control in the country and provides valuable information for improving vector control strategies in Burkina Faso, West Africa.

In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products

Phytomedicine ◽  
2003 ◽  
Vol 10 (4) ◽  
pp. 334-342 ◽  
Author(s):  
B.C. Foster ◽  
S. Vandenhoek ◽  
J. Hana ◽  
A. Krantis ◽  
M.H. Akhtar ◽  
...  
Keyword(s):  
Natural Products ◽  
Cytochrome P450 ◽  
Human Cytochrome ◽  
In Vitro Inhibition
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