Protein tyrosine phosphatases as negative regulators of the immune response

2006 ◽  
Vol 34 (6) ◽  
pp. 1041-1045 ◽  
Author(s):  
G.M. Dolton ◽  
J.G. Sathish ◽  
R.J. Matthews
Keyword(s):  
Immune Response ◽  
Protein Tyrosine Phosphatases ◽  
Host Immunity ◽  
Tyrosine Phosphatases ◽  
Negative Regulators ◽  
Protein Tyrosine

In this mini-review, we provide an overview of those PTPs (protein tyrosine phosphatases) that are relevant to the immune response, highlighting the function of a number of intracellular and transmembrane PTPs that have been identified as having important negative regulatory roles on distinct aspects of host immunity.

Protein tyrosine phosphatases and the immune response

2005 ◽  
Vol 5 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Tomas Mustelin ◽  
Torkel Vang ◽  
Nunzio Bottini
Keyword(s):  
Immune Response ◽  
Protein Tyrosine Phosphatases ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine

scholarly journals Protein Tyrosine Phosphatases: Mechanisms in Cancer

2021 ◽  
Vol 22 (23) ◽  
pp. 12865
Author(s):  
Vignesh Sivaganesh ◽  
Varsha Sivaganesh ◽  
Christina Scanlon ◽  
Alexander Iskander ◽  
Salma Maher ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Protein Tyrosine Phosphatases ◽  
Cancer Therapeutics ◽  
Protein Tyrosine Kinases ◽  
Tyrosine Phosphatases ◽  
Negative Regulators ◽  
Protein Tyrosine ◽  
Target Cancer

Protein tyrosine kinases, especially receptor tyrosine kinases, have dominated the cancer therapeutics sphere as proteins that can be inhibited to selectively target cancer. However, protein tyrosine phosphatases (PTPs) are also an emerging target. Though historically known as negative regulators of the oncogenic tyrosine kinases, PTPs are now known to be both tumor-suppressive and oncogenic. This review will highlight key protein tyrosine phosphatases that have been thoroughly investigated in various cancers. Furthermore, the different mechanisms underlying pro-cancerous and anti-cancerous PTPs will also be explored.

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