Unravelling Nature's networks

2003 ◽  
Vol 31 (6) ◽  
pp. 1457-1461 ◽  
Author(s):  
N.A.M. Monk
Keyword(s):  
Dynamical System ◽  
Mathematical Modelling ◽  
Computational Analysis ◽  
Spatiotemporal Dynamics ◽  
Interaction Networks ◽  
Living Systems ◽  
Cellular Interaction ◽  
Cellular Mechanisms ◽  
Complex Dynamical System ◽  
Insight Into

Dramatic progress has been made recently in determining the genetic and molecular composition of cells. This has prompted the development of new approaches to the challenge of understanding how basic cellular mechanisms are coordinated to produce the dazzling complexity of living systems. To face this challenge fully, it is critical not only to know what genes and proteins are expressed in cells, but also to understand the spatiotemporal dynamics of their networks of interactions. The sheer scale and complexity of cellular interaction networks necessitates a multi-disciplinary effort in which sophisticated experimental techniques are employed in combination with computational analysis and mathematical modelling. Such approaches are beginning to provide insight into basic structures and mechanisms, and promise to become critical to the post-genomic mission of understanding the cell as a complex dynamical system.

scholarly journals Significance of Mast Cell Formed Extracellular Traps in Microbial Defense

2021 ◽  
Author(s):  
Daniel Elieh Ali Komi ◽  
Wolfgang M. Kuebler
Keyword(s):  
State Of The Art ◽  
Extracellular Dna ◽  
Cellular Mechanisms ◽  
Extracellular Traps ◽  
Synthetic Chemicals ◽  
Dna Strands ◽  
Associated Proteins ◽  
Microbial Defense ◽  
And Function ◽  
Insight Into

AbstractMast cells (MCs) are critically involved in microbial defense by releasing antimicrobial peptides (such as cathelicidin LL-37 and defensins) and phagocytosis of microbes. In past years, it has become evident that in addition MCs may eliminate invading pathogens by ejection of web-like structures of DNA strands embedded with proteins known together as extracellular traps (ETs). Upon stimulation of resting MCs with various microorganisms, their products (including superantigens and toxins), or synthetic chemicals, MCs become activated and enter into a multistage process that includes disintegration of the nuclear membrane, release of chromatin into the cytoplasm, adhesion of cytoplasmic granules on the emerging DNA web, and ejection of the complex into the extracellular space. This so-called ETosis is often associated with cell death of the producing MC, and the type of stimulus potentially determines the ratio of surviving vs. killed MCs. Comparison of different microorganisms with specific elimination characteristics such as S pyogenes (eliminated by MCs only through extracellular mechanisms), S aureus (removed by phagocytosis), fungi, and parasites has revealed important aspects of MC extracellular trap (MCET) biology. Molecular studies identified that the formation of MCET depends on NADPH oxidase-generated reactive oxygen species (ROS). In this review, we summarize the present state-of-the-art on the biological relevance of MCETosis, and its underlying molecular and cellular mechanisms. We also provide an overview over the techniques used to study the structure and function of MCETs, including electron microscopy and fluorescence microscopy using specific monoclonal antibodies (mAbs) to detect MCET-associated proteins such as tryptase and histones, and cell-impermeant DNA dyes for labeling of extracellular DNA. Comparing the type and biofunction of further MCET decorating proteins with ETs produced by other immune cells may help provide a better insight into MCET biology in the pathogenesis of autoimmune and inflammatory disorders as well as microbial defense.

scholarly journals Geosystemics and Earthquakes

2018 ◽  
Author(s):  
Angelo De Santis ◽  
Gianfranco Cianchini ◽  
Rita Di Giovambattista ◽  
Cristoforo Abbattista ◽  
Lucilla Alfonsi ◽  
...  
Keyword(s):  
Dynamical System ◽  
Solid Earth ◽  
Case Studies ◽  
Central Italy ◽  
Point Of View ◽  
Earth System ◽  
Complex Dynamical System ◽  
The Earth ◽  
Earth’S Interior

Abstract. Geosystemics (De Santis 2009, 2014) studies the Earth system as a whole focusing on the possible coupling among the Earth layers (the so called geo-layers), and using universal tools to integrate different methods that can be applied to multi-parameter data, often taken on different platforms. Its main objective is to understand the particular phenomenon of interest from a holistic point of view. In this paper we will deal with earthquakes, considered as a long term chain of processes involving, not only the interaction between different components of the Earth’s interior, but also the coupling of the solid earth with the above neutral and ionized atmosphere, and finally culminating with the main rupture along the fault of concern (De Santis et al., 2015a). Some case studies (particular emphasis is given to recent central Italy earthquakes) will be discussed in the frame of the geosystemic approach for better understanding the physics of the underlying complex dynamical system.

scholarly journals The Mathematical Proficiency Promoted by Mathematical Modelling

2021 ◽  
Vol 4 (2) ◽  
pp. 107-131
Author(s):  
Priscila Dias Corrêa ◽  
Keyword(s):  
High School Students ◽  
Mathematical Modelling ◽  
Mathematics Teaching ◽  
Research Study ◽  
Mathematical Work ◽  
School Students ◽  
Design Based Research ◽  
Video Recordings ◽  
Mathematical Proficiency ◽  
Insight Into

This study aims to investigate the mathematical proficiency promoted by mathematical modelling tasks that require students to get involved in the processes of developing mathematical models, instead of just using known or given models. The research methodology is grounded on design-based research, and the classroom design framework is supported by complexity science underpinnings. The research intervention consists of high-school students, from a grade 11 mathematics course, aiming to solve four different modelling tasks in four distinct moments. Data was collected during the intervention from students’ written mathematical work and audio and video recordings, and from recall interviews after the intervention. Data analysis was conducted based on a model of mathematical proficiency and assisted by interpretive diagrams created for this research purpose. This research study offers insight into mathematics teaching by portraying how mathematical modelling tasks can be integrated into mathematics classes to promote students’ mathematical proficiency. The study discusses observed expressions and behaviours in students’ development of mathematical proficiency and suggests a relationship between mathematical modelling processes and the promotion of mathematical proficiency. The study also reveals that students develop mathematical proficiency, even when they do not come to full resolutions of modelling tasks, which emphasizes the relevance of learning processes, and not only of the products of these processes.

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