Involvement of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins in mRNA turnover

2002 ◽  
Vol 30 (5) ◽  
pp. A115-A115
Author(s):  
Perry J. Blackshear
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Mrna Turnover ◽  
Tandem Zinc Finger

Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover

2002 ◽  
Vol 30 (6) ◽  
pp. 945-952 ◽  
Author(s):  
P. J. Blackshear
Keyword(s):  
Zinc Finger ◽  
Family Members ◽  
Zinc Finger Proteins ◽  
Macrophage Colony Stimulating Factor ◽  
Complex Regulation ◽  
Macrophage Colony ◽  
The Stability ◽  
Factor Α ◽  
Necrosis Factor ◽  
Tandem Zinc Finger

The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three known members in mammals, with a fourth member recently identified in frogs and fish. Although TTP was first cloned more than 10 years ago as a growth factor-induced gene, a physiological function for the protein has been discovered only within the last few years. TTP is now known to bind to so-called class II AU-rich elements within the mRNAs that encode tumour necrosis factor-α and granulocyte/macrophage colony-stimulating factor. In both cases, this binding results in destabilization of the mRNA and decreased secretion of the protein. Recent evidence suggests that TTP can accomplish this accelerated mRNA degradation by first promoting removal of the polyadenylated tail from the mRNA (deadenylation). In functional assays in cells, the other family members have similar activities, but are expressed differently in tissues and in response to stimuli, suggesting that they may control the stability of mRNAs under different circumstances from those in which TTP affects mRNA. All of these proteins are phosphoproteins and nucleo-cytoplasmic shuttling proteins, suggesting that their activities can be regulated in ways other than regulating gene transcription. Together, the TTP family members should be capable of complex regulation of short-lived mRNAs containing this type of AU-rich instability motif.

The RNA recognition code of C. elegans CCCH‐type tandem zinc finger proteins

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Sean Patrick Ryder ◽  
John M. Pagano ◽  
Brian M. Farley ◽  
Lisa M. McCoig
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Rna Recognition ◽  
C Elegans ◽  
Recognition Code ◽  
Tandem Zinc Finger

scholarly journals DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins

Cell ◽  
2018 ◽  
Vol 173 (1) ◽  
pp. 221-233.e12 ◽  
Author(s):  
Anamika Patel ◽  
Peng Yang ◽  
Matthew Tinkham ◽  
Mihika Pradhan ◽  
Ming-An Sun ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
Dna Conformation ◽  
Tandem Zinc Finger

scholarly journals Zfp36l3, a Rodent X Chromosome Gene Encoding a Placenta-Specific Member of the Tristetraprolin Family of CCCH Tandem Zinc Finger Proteins

2005 ◽  
Vol 73 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Perry J. Blackshear ◽  
Ruth S. Phillips ◽  
Sanjukta Ghosh ◽  
Silvia V.B. Ramos ◽  
Eric K. Richfield ◽  
...  
Keyword(s):  
Zinc Finger ◽  
X Chromosome ◽  
Zinc Finger Proteins ◽  
Gene Encoding ◽  
Chromosome Gene ◽  
Tandem Zinc Finger

scholarly journals Engineering Zinc Finger Proteins using Accessory Binding Modules

2012 ◽  
Vol 102 (3) ◽  
pp. 74a
Author(s):  
Kathryn Trenshaw ◽  
Younghoon Kim ◽  
Nathan Yee ◽  
Peiyi Wang ◽  
Charles Schroeder
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins

scholarly journals Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kazuhiro Suzuki ◽  
Kosuke Sako ◽  
Kazuhiro Akiyama ◽  
Michitaka Isoda ◽  
Chiharu Senoo ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Proteins ◽  
C2h2 Zinc Finger ◽  
Consensus Motifs ◽  
Mitotic Regulation
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