Structure of a hepatitis C virus IRES RNA motif recognized by translation initiation factor 3

2002 ◽  
Vol 30 (1) ◽  
pp. A18-A18
Author(s):  
José Gallego ◽  
Roscoe Klinck ◽  
A. Collier ◽  
G. Harrison ◽  
S. Harris ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Rna Motif ◽  
Translation Initiation Factor 3

scholarly journals Iron Regulates Hepatitis C Virus Translation via Stimulation of Expression of Translation Initiation Factor 3

2004 ◽  
Vol 190 (4) ◽  
pp. 819-825 ◽  
Author(s):  
Igor Theurl ◽  
Heinz Zoller ◽  
Peter Obrist ◽  
Christian Datz ◽  
Felix Bachmann ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Translation Initiation Factor 3 ◽  
Stimulation Of

scholarly journals Control of Paip1-Eukayrotic Translation Initiation Factor 3 Interaction by Amino Acids through S6 Kinase

2014 ◽  
Vol 34 (6) ◽  
pp. 1046-1053 ◽  
Author(s):  
Y. Martineau ◽  
X. Wang ◽  
T. Alain ◽  
E. Petroulakis ◽  
D. Shahbazian ◽  
...  
Keyword(s):  
Amino Acids ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
S6 Kinase ◽  
Translation Initiation Factor 3

scholarly journals Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Zane A Jaafar ◽  
Akihiro Oguro ◽  
Yoshikazu Nakamura ◽  
Jeffrey S Kieft
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Translation Initiation ◽  
Rna Structure ◽  
Initiation Factor ◽  
Internal Ribosome Entry ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
Hcv Ires ◽  
Type 3

Internal ribosome entry sites (IRESs) are important RNA-based translation initiation signals, critical for infection by many pathogenic viruses. The hepatitis C virus (HCV) IRES is the prototype for the type 3 IRESs and is also invaluable for exploring principles of eukaryotic translation initiation, in general. Current mechanistic models for the type 3 IRESs are useful but they also present paradoxes, including how they can function both with and without eukaryotic initiation factor (eIF) 2. We discovered that eIF1A is necessary for efficient activity where it stabilizes tRNA binding and inspects the codon-anticodon interaction, especially important in the IRES’ eIF2-independent mode. These data support a model in which the IRES binds preassembled translation preinitiation complexes and remodels them to generate eukaryotic initiation complexes with bacterial-like features. This model explains previous data, reconciles eIF2-dependent and -independent pathways, and illustrates how RNA structure-based control can respond to changing cellular conditions.

scholarly journals 1H, 13C and 15N resonance assignments of translation initiation factor 3 from Pseudomonas aeruginosa

2020 ◽  
Vol 14 (1) ◽  
pp. 93-97
Author(s):  
Libo Li ◽  
Stephanie O. Palmer ◽  
Elizabeth A. Gomez ◽  
Frank Mendiola ◽  
Tianzhi Wang ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Translation Initiation ◽  
Resonance Assignments ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Translation Initiation Factor 3
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