HRS regulates endosomal trafficking and tyrosine kinase receptor signaling

2001 ◽  
Vol 29 (3) ◽  
pp. A84-A84
Author(s):  
T. E. Lloyd ◽  
R. A. Atkinson ◽  
M. N. Wu ◽  
H. J. Bellen
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptor ◽  
Endosomal Trafficking ◽  
Receptor Signaling

scholarly journals Survival of the weakest: signaling aided by endosomes

2008 ◽  
Vol 182 (5) ◽  
pp. 823-825 ◽  
Author(s):  
Marisa P. McShane ◽  
Marino Zerial
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Cell Biology ◽  
Tyrosine Kinase Receptor ◽  
Endosomal Trafficking ◽  
Spatiotemporal Regulation ◽  
Molecular Machinery ◽  
Factor C ◽  
Hepatocyte Growth ◽  
Major Target

The tyrosine kinase receptor c-Met plays a key role in cell proliferation, morphogenesis, and motility in response to hepatocyte growth factor. C-Met is often altered in cancer and is a major target for therapeutic intervention. Despite knowing a great deal of the molecular machinery downstream of this receptor tyrosine kinase, the spatiotemporal regulation of c-Met signaling still remains elusive. In this issue of the Journal of Cell Biology, Kermorgant and Parker (Kermorgant, S. and P.J. Parker. 2008. J. Cell Biol. 182:855–863) provide evidence for a model in which the c-Met–activated STAT3 signal is mediated by endosomal trafficking. This study elegantly highlights how weak signals can be effectively transmitted to the nucleus by exploiting endosomal compartments, raising important mechanistic implications for the signaling research community.

scholarly journals Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

Cell ◽  
2002 ◽  
Vol 108 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Thomas E. Lloyd ◽  
Richard Atkinson ◽  
Mark N. Wu ◽  
Yi Zhou ◽  
Giuseppa Pennetta ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptor ◽  
Receptor Signaling ◽  
Membrane Invagination

scholarly journals Author response: Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling

2014 ◽  
Author(s):  
Marlen Zschätzsch ◽  
Carlos Oliva ◽  
Marion Langen ◽  
Natalie De Geest ◽  
Mehmet Neset Özel ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Author Response ◽  
Tyrosine Kinase Receptor ◽  
Receptor Signaling

Axl and Met: Crosstalk of Tyrosine Kinase Receptor Signaling in GnRH Neurons

2011 ◽  
pp. P2-276-P2-276
Author(s):  
Smita Salian Mehta ◽  
Mei Xu ◽  
Melinda Schaller ◽  
Margaret E Wierman
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptor ◽  
Receptor Signaling ◽  
Gnrh Neurons
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