Peroxisomal fatty acid alpha- and beta-oxidation in humans: new insights into enzymology, substrate specificities, metabolite transport and peroxisomal diseases

2001 ◽  
Vol 29 (1) ◽  
pp. A2-A2
Author(s):  
R. J. A. Wanders ◽  
S. Ferdinandusse ◽  
G. A. Jansen ◽  
E. G. van Grusven ◽  
H. R. Waterham ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Beta Oxidation ◽  
Metabolite Transport ◽  
Substrate Specificities ◽  
Peroxisomal Fatty Acid

Role of peroxisomal fatty acid beta-oxidation in ethanol metabolism

1989 ◽  
Vol 163 (1) ◽  
pp. 418-423 ◽  
Author(s):  
Nobuhiro Inatomi ◽  
Shinzo Kato ◽  
Daisuke Ito ◽  
Charles S. Lieber
Keyword(s):  
Fatty Acid ◽  
Ethanol Metabolism ◽  
Beta Oxidation ◽  
Fatty Acid Beta Oxidation ◽  
Peroxisomal Fatty Acid

scholarly journals Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα

2021 ◽  
Vol 22 (16) ◽  
pp. 8969
Author(s):  
Mounia Tahri-Joutey ◽  
Pierre Andreoletti ◽  
Sailesh Surapureddi ◽  
Boubker Nasser ◽  
Mustapha Cherkaoui-Malki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Mammalian Cells ◽  
Atp Synthesis ◽  
Peroxisome Proliferator ◽  
Beta Oxidation ◽  
Peroxisome Proliferator Activated Receptor ◽  
Oxidation Pathway ◽  
Oxidative Phosphorylation Pathway ◽  
Peroxisome Proliferator Response Element ◽  
Peroxisomal Fatty Acid

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation pathway, a distinct mitochondrial system feeds the oxidative phosphorylation pathway for ATP synthesis. At the same time, the peroxisomal β-oxidation pathway participates in cellular thermogenesis. A scientific milestone in 1965 helped discover the hepatomegaly effect in rat liver by clofibrate, subsequently identified as a peroxisome proliferator in rodents and an activator of the peroxisomal fatty acid β-oxidation pathway. These peroxisome proliferators were later identified as activating ligands of Peroxisome Proliferator-Activated Receptor α (PPARα), cloned in 1990. The ligand-activated heterodimer PPARα/RXRα recognizes a DNA sequence, called PPRE (Peroxisome Proliferator Response Element), corresponding to two half-consensus hexanucleotide motifs, AGGTCA, separated by one nucleotide. Accordingly, the assembled complex containing PPRE/PPARα/RXRα/ligands/Coregulators controls the expression of the genes involved in liver peroxisomal fatty acid β-oxidation. This review mobilizes a considerable number of findings that discuss miscellaneous axes, covering the detailed expression pattern of PPARα in species and tissues, the lessons from several PPARα KO mouse models and the modulation of PPARα function by dietary micronutrients.

Peroxisomal Fatty Acid Alpha-and Beta-Oxidation in Health and Disease: New insights

2003 ◽  
pp. 293-302 ◽  
Author(s):  
Ronald J.A. Wanders ◽  
Carlo W.T. Van Roermund ◽  
Wouter F. Visser ◽  
Sacha Ferdinandusse ◽  
Gerbert A. Jansen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Beta Oxidation ◽  
Health And Disease ◽  
Peroxisomal Fatty Acid

Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation

2012 ◽  
Vol 13 (10) ◽  
pp. 1412-1421 ◽  
Author(s):  
Mustapha Cherkaoui-Malki ◽  
Sailesh Surapureddi ◽  
Hammam I. El Hajj ◽  
Joseph Vamecq ◽  
Pierre Andreoletti
Keyword(s):  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Beta Oxidation ◽  
Fatty Acid Beta Oxidation ◽  
Peroxisomal Fatty Acid

Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation

2011 ◽  
Vol 1811 (3) ◽  
pp. 148-152 ◽  
Author(s):  
Carlo W.T. van Roermund ◽  
Wouter F. Visser ◽  
Lodewijk IJlst ◽  
Hans R. Waterham ◽  
Ronald J.A. Wanders
Keyword(s):  
Fatty Acid ◽  
Substrate Specificities ◽  
Peroxisomal Fatty Acid

The Arabidopsis acyl-CoA oxidase gene family

2000 ◽  
Vol 28 (6) ◽  
pp. 755-757 ◽  
Author(s):  
P. J. Eastmond ◽  
M. Hooks ◽  
I. A. Graham
Keyword(s):  
Fatty Acid ◽  
Full Range ◽  
Biochemical Properties ◽  
Oxidase Gene ◽  
Substrate Specificities ◽  
Fatty Acid Chain ◽  
Acyl Coa Oxidase ◽  
Chain Lengths ◽  
Peroxisomal Fatty Acid

A family of acyl-CoA oxidase isozymes catalyse the first step in the peroxisomal fatty acid β-oxidation spiral. Our group and others have recently characterized four genes from this family in the model oilseed Arabidopsis. These genes encode isozymes with different acyl-CoA substrate specificities, which together encompass the full range of fatty acid chain lengths that exist in vivo. Here we review the biochemical properties and physiological roles of the acyl-CoA oxidase isozymes.

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