Role of reactive oxygen species in cell signalling pathways

2001 ◽  
Vol 29 (2) ◽  
pp. 345-349 ◽  
Author(s):  
J. T. Hancock ◽  
R. Desikan ◽  
S.J. Neill
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Signalling ◽  
Reactive Oxygen ◽  
Signalling Pathways ◽  
Oxygen Species ◽  
Phagocytic Cells ◽  
Mitogen Activated Protein ◽  
A Cell ◽  
Activate Cell

Reactive oxygen species (ROS) were originally thought to only be released by phagocytic cells during their role in host defence. It is now clear that ROS have a cell signalling role in many biological systems, both in animals and in plants. ROS induce programmed cell death or necrosis, induce or suppress the expression of many genes, and activate cell signalling cascades, such as those involving mitogen-activated protein kinases.

scholarly journals Oxidative stress in marathon runners: interest of antioxidant supplementation

2006 ◽  
Vol 96 (S1) ◽  
pp. S31-S33 ◽  
Author(s):  
Mari-Carmen Gomez-Cabrera ◽  
Agustín Martínez ◽  
Gustavo Santangelo ◽  
Federico V. Pallardó ◽  
Juan Sastre ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Xanthine Oxidase ◽  
Cell Signalling ◽  
Reactive Oxygen ◽  
Peripheral Blood Lymphocytes ◽  
Signalling Pathways ◽  
Marathon Running ◽  
Oxygen Species ◽  
Marathon Runners

We have recently reported that xanthine oxidase is involved in the generation of free radicals in exhaustive exercise. Allopurinol, an inhibitor of xanthine oxidase, prevents it. The aim of the present work was to elucidate the role of exercise-derived reactive oxygen species in the cell signalling pathways involved in the adaptation to exercise in man. We have found that exercise causes an increase in the activity of plasma xanthine oxidase and an activation of NF-κB in peripheral blood lymphocytes after marathon running. This activation is dependent on free radical formation in exercise: treatment with allopurinol completely prevents it. In animal models, we previously showed that NF-κB activation induced by exhaustive physical exercise leads to an increase in the expression of superoxide dismutase, an enzyme involved in antioxidant defence. We report evidence in man that reactive oxygen species act as signals in exercise as decreasing their formation prevents activation of important signalling pathways which can cause useful adaptations in cells.

scholarly journals Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium

2005 ◽  
Vol 33 (6) ◽  
pp. 1385 ◽  
Author(s):  
A. Landar ◽  
J.W. Zmijewski ◽  
N. Watanabe ◽  
D.A. Dickinson ◽  
N. Noguchi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Signalling ◽  
Reactive Oxygen ◽  
Oxidized Lipids ◽  
Oxygen Species

scholarly journals Reactive oxygen species act as mediators in endothelial cell signalling pathways

1996 ◽  
Vol 27 (2) ◽  
pp. 385
Author(s):  
Kaikobad Irani ◽  
Steven Sollott ◽  
Loren Rosolowski ◽  
Toren Finkei ◽  
Maitrayee Sundaresan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cell ◽  
Cell Signalling ◽  
Reactive Oxygen ◽  
Signalling Pathways ◽  
Oxygen Species
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