CYSTEINE RESIDUES ARE INVOLVED IN THE STRUCTURE AND FUNCTION OF MELANOCORTIN 1 RECEPTORS

2000 ◽  
Vol 28 (5) ◽  
pp. A266-A266
Author(s):  
M. Doufexis ◽  
P-A Frändberg ◽  
S. Kapas ◽  
V. Chhajlani
Keyword(s):  
Structure And Function ◽  
Cysteine Residues ◽  
And Function

scholarly journals Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
J. Santiago Mejia ◽  
Erik N. Arthun ◽  
Richard G. Titus
Keyword(s):  
Plasmodium Falciparum ◽  
Amino Acid ◽  
Distribution Patterns ◽  
Structural Features ◽  
Structure And Function ◽  
Cysteine Residues ◽  
Distribution Analysis ◽  
And Function ◽  
Abundance And Distribution ◽  
Host Parasite

One approach to identify epitopes that could be used in the design of vaccines to control several arthropod-borne diseases simultaneously is to look for common structural features in the secretome of the pathogens that cause them. Using a novel bioinformatics technique, cysteine-abundance and distribution analysis, we found that many different proteins secreted by several arthropod-borne pathogens, includingPlasmodium falciparum, Borrelia burgdorferi, and eight species of Proteobacteria, are devoid of cysteine residues. The identification of three cysteine-abundance and distribution patterns in several families of proteins secreted by pathogenic and nonpathogenic Proteobacteria, and not found when the amino acid analyzed was tryptophan, provides evidence of forces restricting the content of cysteine residues in microbial proteins during evolution. We discuss these findings in the context of protein structure and function, antigenicity and immunogenicity, and host-parasite relationships.

The role of individual cysteine residues in the structure and function of the v-sis gene product

Science ◽  
1987 ◽  
Vol 236 (4806) ◽  
pp. 1315-1318 ◽  
Author(s):  
N. Giese ◽  
K. Robbins ◽  
S. Aaronson
Keyword(s):  
Gene Product ◽  
Structure And Function ◽  
Cysteine Residues ◽  
And Function

scholarly journals Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL

Virology ◽  
2005 ◽  
Vol 332 (2) ◽  
pp. 550-562 ◽  
Author(s):  
Tina M. Cairns ◽  
Daniel J. Landsburg ◽  
J. Charles Whitbeck ◽  
Roselyn J. Eisenberg ◽  
Gary H. Cohen
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Structure And Function ◽  
Cysteine Residues ◽  
Simplex Virus ◽  
And Function

scholarly journals Versatility and Differential Roles of Cysteine Residues in Human Prostacyclin Receptor Structure and Function

2006 ◽  
Vol 281 (48) ◽  
pp. 37227-37236 ◽  
Author(s):  
Jeremiah Stitham ◽  
Scott R. Gleim ◽  
Karen Douville ◽  
Eric Arehart ◽  
John Hwa
Keyword(s):  
Structure And Function ◽  
Cysteine Residues ◽  
Receptor Structure ◽  
Prostacyclin Receptor ◽  
And Function

scholarly journals Native cysteine residues are dispensable for the structure and function of all five yeast mitotic septins

2013 ◽  
Vol 81 (11) ◽  
pp. 1964-1979 ◽  
Author(s):  
Natalia Val ◽  
Michael A. McMurray ◽  
Lisa H. Lam ◽  
Chris C.‐S. Hsiung ◽  
Aurélie Bertin ◽  
...  
Keyword(s):  
Structure And Function ◽  
Cysteine Residues ◽  
And Function
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