A Solid State NMR Approach to the Structure-Activity Relationship of the Nucleoside Transport Protein NupC of Escherichia coli

2000 ◽  
Vol 28 (3) ◽  
pp. A89-A89
Author(s):  
S.G. Patching ◽  
P.J.F. Henderson ◽  
P.J.R. Spooner ◽  
A. Watts ◽  
S.A. Baldwin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Solid State ◽  
Solid State Nmr ◽  
Structure Activity Relationship ◽  
Transport Protein ◽  
Nucleoside Transport ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Structure–Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting Escherichia coli

2019 ◽  
Vol 62 (22) ◽  
pp. 10245-10257
Author(s):  
Jiaqing Wang ◽  
Adrianna Shy ◽  
Difei Wu ◽  
Deani L. Cooper ◽  
Jiashu Xu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis

1994 ◽  
Vol 14 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Mariagrazia Pizza ◽  
Mario Domenighini ◽  
Wim Hol ◽  
Valentine Giannelli ◽  
Maria Rita Fontana ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structure Activity Relationship ◽  
Site Directed Mutagenesis ◽  
Activity Relationship ◽  
Directed Mutagenesis ◽  
Structure Activity ◽  
Relationship Of

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview

2019 ◽  
Vol 23 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Qiang Zhang ◽  
Xude Wang ◽  
Liyan Lv ◽  
Guangyue Su ◽  
Yuqing Zhao
Keyword(s):  
Structural Modification ◽  
Gastrointestinal Disease ◽  
Structure Activity Relationship ◽  
Cerebrovascular Diseases ◽  
Activity Relationship ◽  
Cycle Arrest ◽  
Structure Activity ◽  
Wide Range ◽  
Structural Association ◽  
Relationship Of

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.

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