Heterologous expression of nicotinic acetylcholine receptors in mammalian and Drosophila cell lines: the importance of the host cell environment

1999 ◽  
Vol 27 (5) ◽  
pp. A143-A143
Author(s):  
Neil S. Millar
Keyword(s):  
Heterologous Expression ◽  
Host Cell ◽  
Cell Lines ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Drosophila Cell

scholarly journals Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets

Marine Drugs ◽  
2019 ◽  
Vol 17 (5) ◽  
pp. 256 ◽  
Author(s):  
Yiqiao Liu ◽  
Jiang Qian ◽  
Zhihua Sun ◽  
Dongting Zhangsun ◽  
Sulan Luo
Keyword(s):  
Cervical Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Cervical Cancer Cell ◽  
Nicotinic Acetylcholine ◽  
Nachr Subtype ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Nicotinic acetylcholine receptors (nAChRs) are associated with various cancers, but the relation between nAChRs and cervical cancer remains unclear. Therefore, this study investigated the differential expression of nAChR subunits in human cervical cancer cell lines (SiHa, HeLa, and CaSki) and in normal ectocervical cell lines (Ect1/E6E7) at mRNA and protein levels. Two specific nAChR subtype blockers, αO-conotoxin GeXIVA and α-conotoxin TxID, were then selected to treat different human cervical cancer cell lines with specific nAChR subtype overexpression. The results showed that α3, α9, α10, and β4 nAChR subunits were overexpressed in SiHa cells compared with that in normal cells. α9 and α10 nAChR subunits were overexpressed in CaSki cells. α*-conotoxins that targeted either α9α10 or α3β4 nAChR were able to significantly inhibit cervical cancer cell proliferation. These findings may provide a basis for new targets for cervical cancer targeted therapy.

Functional Nicotinic Acetylcholine Receptors Are Expressed in B Lymphocyte-Derived Cell Lines

2003 ◽  
Vol 64 (4) ◽  
pp. 885-889 ◽  
Author(s):  
Marina V. Skok ◽  
Elena N. Kalashnik ◽  
Ludmila N. Koval ◽  
Victor I. Tsetlin ◽  
Yuriy N. Utkin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
B Lymphocyte ◽  
Nicotinic Acetylcholine

scholarly journals Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135811 ◽  
Author(s):  
Avi Ring ◽  
Bjorn Oddvar Strom ◽  
Simon R. Turner ◽  
Christopher M. Timperley ◽  
Michael Bird ◽  
...  
Keyword(s):  
Cell Lines ◽  
Human Cell ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Human Cell Lines ◽  
Nicotinic Acetylcholine
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