Heterologous expression of the red-cell anion exchanger (band 3; AEI)

1999 ◽  
Vol 27 (6) ◽  
pp. 917-923 ◽  
Author(s):  
Jonathan D. Groves ◽  
Mark D. Parker ◽  
David Askin ◽  
Pierre Falson ◽  
Marc le Maire ◽  
...  
Keyword(s):  
Heterologous Expression ◽  
Anion Exchanger ◽  
Band 3 ◽  
Red Cell

scholarly journals Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context

2016 ◽  
Vol 1858 (7) ◽  
pp. 1507-1532 ◽  
Author(s):  
Reinhart A.F. Reithmeier ◽  
Joseph R. Casey ◽  
Antreas C. Kalli ◽  
Mark S.P. Sansom ◽  
Yilmaz Alguel ◽  
...  
Keyword(s):  
Anion Exchanger ◽  
Band 3 ◽  
Red Cell ◽  
Structural Context

Physiological influence of complete lack of red cell anion exchanger in cattle with hereditary band 3 deficiency

1994 ◽  
Vol 1 ◽  
pp. 235
Author(s):  
Mutsumi Inaba ◽  
Miyuki Takeuchi ◽  
Kota Sato ◽  
Ken-ichiro Ono ◽  
Yoshimitsu Maede
Keyword(s):  
Anion Exchanger ◽  
Band 3 ◽  
Red Cell

Structural Studies on the Effects of the Deletion in the Red Cell Anion Exchanger (band 3, AE1) Associated with South East Asian Ovalocytosis

1999 ◽  
Vol 285 (3) ◽  
pp. 1289-1307 ◽  
Author(s):  
Eric J. Chambers ◽  
Graham B. Bloomberg ◽  
Susan M. Ring ◽  
Michael J.A. Tanner
Keyword(s):  
Anion Exchanger ◽  
East Asian ◽  
Band 3 ◽  
Red Cell ◽  
Structural Studies

scholarly journals Topology studies with biosynthetic fragments identify interacting transmembrane regions of the human red-cell anion exchanger (band 3; AE1)

1999 ◽  
Vol 344 (3) ◽  
pp. 687-697 ◽  
Author(s):  
Jonathan D. GROVES ◽  
Michael J. A. TANNER
Keyword(s):  
Anion Exchanger ◽  
Band 3 ◽  
Glycosylation Site ◽  
Intramolecular Interactions ◽  
Red Cell ◽  
Chloride Uptake ◽  
C Terminus ◽  
Free Translation ◽  
Membrane Spanning ◽  
General Method

The red-cell anion exchanger (band 3; AE1) is a multispanning membrane protein that traverses the bilayer up to 14 times and is N-glycosylated at Asn-642. We have shown that the integrity of six different loops are not essential for stilbene disulphonate-sensitive chloride uptake in Xenopus oocytes. We used an N-glycosylation mutagenesis approach to examine the orientation of the N-terminus and the endogenous glycosylation site of each C-terminal fragment by cell-free translation. The fragments initiating in the loops preceding spans 2, 9 and 11 did not insert into the membrane with the expected orientation. Furthermore, N-glycosylation of Asn-642 might facilitate the membrane integration of span 7. The correct integration of spans 2-3 required the presence of the region containing span 4 and that the luminal exposure of the C-terminus of span 7 is increased in the presence of the region including span 6 or span 8. The results suggest the span 8 region is required for the correct folding of spans 9-10, at least in the presence of the span 11-12 region. Our results suggest that there are intramolecular interactions between the regions of transmembrane spans 1 and 2, 2 and 4, 4 and 5, 7 and 8, 8 and 9-10, and 9-10 and 11-12. Spans 1, 4, 5, 6 and 8 might act as a scaffold for the assembly of spans 2-3, 7 and 9-10. This approach might provide a general method for dissecting the interactions between membrane-spanning regions of polytopic membrane proteins.

scholarly journals Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene.

1997 ◽  
Vol 100 (7) ◽  
pp. 1693-1707 ◽  
Author(s):  
L J Bruce ◽  
D L Cope ◽  
G K Jones ◽  
A E Schofield ◽  
M Burley ◽  
...  
Keyword(s):  
Renal Tubular Acidosis ◽  
Anion Exchanger ◽  
Band 3 ◽  
Distal Renal Tubular Acidosis ◽  
Red Cell ◽  
Renal Tubular

Studies on the structure of a transmembrane region and a cytoplasmic loop of the human red cell anion exchanger (band 3, AE1)

1998 ◽  
Vol 26 (3) ◽  
pp. 516-520 ◽  
Author(s):  
E. J. Chambers ◽  
D. Askin ◽  
G. B. Bloomberg ◽  
S. M. Ring ◽  
M. J. A. Tanner
Keyword(s):  
Anion Exchanger ◽  
Band 3 ◽  
Red Cell ◽  
Transmembrane Region ◽  
Cytoplasmic Loop
Sign in / Sign up

Export Citation Format

Share Document