Studies on the down-regulation of major histocompatibility complex class I gene expression in adenovirus-transformed cells

1997 ◽  
Vol 25 (2) ◽  
pp. 352S-352S ◽  
Author(s):  
NICOLA J. PHILPOTT ◽  
JAMES A. PROFFITT ◽  
G. ERIC BLAIR
Keyword(s):  
Gene Expression ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Transformed Cells ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Down Regulation ◽  
Histocompatibility Complex ◽  
I Gene

scholarly journals Evidence for the involvement of a nuclear NF-kappa B inhibitor in global down-regulation of the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells.

1996 ◽  
Vol 16 (1) ◽  
pp. 398-404 ◽  
Author(s):  
X Liu ◽  
R Ge ◽  
R P Ricciardi
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Adenovirus Type ◽  
Class I ◽  
Transformed Cells ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Nf Kappa B ◽  
Down Regulation ◽  
Histocompatibility Complex

Diminished expression of major histocompatibility complex class I antigens on the surface of adenovirus type 12 (Ad12)-transformed cells contributes to their high tumorigenic potential by enabling them to escape immune recognition by cytotoxic T lymphocytes. This low class I antigen expression is due to a block in class I transcription, which is mediated by Ad12 E1A. Genetic analysis has shown that the class I enhancer is the target for transcriptional down-regulation. In this study, we show that the ability of the R1 element of the class I enhancer to stimulate transcription is greatly reduced in Ad12-transformed cells. The loss of functional activity by the R1 element was attributed to loss of binding by the NF-kappa B p50-p65 heterodimer. NF-kappa B binding appears to be blocked within the nucleus rather than at the level of nuclear translocation. Significantly, NF-kappa B binding activity could be recovered from the nuclear extracts of Ad12-transformed cells following detergent treatment, suggesting that the block is mediated through a nuclear inhibitor present in the Ad12-transformed cells. These results, taken together with the fact that the R2 element of the class I enhancer exhibits strong binding to the transcriptional repressor COUP-TF, suggest that the class I enhancer is globally down-regulated in Ad12-transformed cells.

Classical and non-classical Major Histocompatibility Complex class I gene expression in in vitro derived bovine embryos

2009 ◽  
Vol 82 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Julie Doyle ◽  
Shirley A. Ellis ◽  
Grace M. O’Gorman ◽  
Ines Maria Aparicio Donoso ◽  
Patrick Lonergan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Complex Class ◽  
Bovine Embryos ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
I Gene

scholarly journals Regulation of Major Histocompatibility Complex Class I Gene Expression in Thyroid Cells

1997 ◽  
Vol 272 (32) ◽  
pp. 20096-20107 ◽  
Author(s):  
Motoyasu Saji ◽  
Minho Shong ◽  
Giorgio Napolitano ◽  
Lisa A. Palmer ◽  
Shin-Ichi Taniguchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Class I ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Thyroid Cells ◽  
Histocompatibility Complex ◽  
I Gene
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