Herpes virus-specific immune responses in individuals experiencing recurrent genital herpes

1997 ◽  
Vol 25 (2) ◽  
pp. 278S-278S
Author(s):  
Christopher M. Boswell ◽  
Imogen A. Duncan ◽  
Julie Uttridge ◽  
Christopher Sonnex ◽  
Julian K. Hickling
Keyword(s):  
Immune Responses ◽  
Genital Herpes ◽  
Herpes Virus ◽  
Recurrent Genital Herpes ◽  
Herpès Virus

Immunological aspects of pathogenetic therapy of genital herpes by intravenous laser light of blood

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Зиганшин ◽  
O. Ziganshin ◽  
Москвин ◽  
S. Moskvin ◽  
Гизингер ◽  
...  
Keyword(s):  
Genital Herpes ◽  
Herpes Virus ◽  
Laser Light ◽  
Clinical Signs ◽  
Recurrent Genital Herpes ◽  
Laser Ultrasonic ◽  
Complex Therapy ◽  
Recurrent Herpes ◽  
Pathogenetic Therapy ◽  
Herpès Virus

Chronic recurrent herpes virus infection of the genitals caused by the herpes virus type 2 is an inflammatory polyetiological disease, in the pathogenesis of which the reduction of non-specific resistance of the organism, an imbalance of immune factors plays an important role. Treatment of genital herpes infection should cover all the links of pathogenesis, including immunological. Clinical and immunological assessment of the effectiveness of intravenous laser light of blood in the UV spectral range (wavelength 365 nm, the device "Lasmik- VLOK") was carried out. This study involved 79 women at the age of 29,9±0,2 years with clinical signs of chronic recurrent genital herpes. Etiotropic therapy was conducted with the use of the Aciclovir in a dose of 500 mg once a day for 6 months. The complex therapy included the use of laser ultrasonic irradiation of blood simultaneously with the application of standard methods of treatment. The results of the study indicate the presence of positive clinical dynamics and immune-modulating activity of laser ultrasonic spectrum, that allows to recommend this method in complex therapy of chronic recurrent genital herpes.

scholarly journals Viremia in Equine Herpes Virus-1 infection and a possible link to Transient Protective Immunity

2021 ◽  
Vol 9 (1) ◽  
pp. 11-16
Author(s):  
AR Awan ◽  
OL Tulp ◽  
HJ Field
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Murine Model ◽  
Herpes Virus ◽  
Natural Infection ◽  
Fluorescent Antibody ◽  
Buffy Coat ◽  
Effective Vaccine ◽  
Infection Model ◽  
Herpès Virus

Equine herpes virus (EHV-1) causes respiratory infections in equine, and results in abortion, paresis, neonatal death, and retinopathy and the virus may become latent following initial infection. Virus entry is via the respiratory route, and the virus replicates in the host in ciliated and non-ciliated epithelial cells of the respiratory tract and in Type 1 and Type 2 pneumocytes in the lung parenchyma. After viral replication in the respiratory system, the virus can become disseminated to other parts of body via viraemic cells. The virus also can cross the placenta which leads to abortion of live or dead fetuses without premonitory signs. Infected horses show transient immunity after natural or experimental infection and immune responses to EHV-1, but the immunoprotective status begins to decline after a few months of active infection. Due to the transient immune response, recovered horses are not immunoprotected and thus are prone to subsequent re-infection. Immunity is not long lived after experimental or natural infection, and as a result the development of an effective vaccine has remained a challenge. In this study viraemic cells were studied in a murine EHV-1 infection model. Mice were infected intranasally and viraemic cells were studied on days three and five which occurs during the peak of the infection. The results of this study may help to identify the nature of viraemic cells and their role in the transient immune response to infection. Buffy coat cells and lungs were removed and stained with a fluorescent antibody test for EHV-1 antigen, and lung specimens were subjected to transmission electron microscopy. Both techniques confirmed the presence of viraemic cells in lung tissues. These viraemic cells were further stained for EHV-1 antigen, and for CD4 or CD8 biomarkers and results are discussed re: pathogenesis of EHV-1 infection, identification of viraemic cells in a murine model and possible link of viraemia to transient immune responses in EHV-1 infection, which demonstrate the validity of this murine model for the investigation of the cytopathologic mechanism and sequelae of EHV manifestation in this model.

Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus

2003 ◽  
Vol 54 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Deidre Byrnes Pereira ◽  
Michael H Antoni ◽  
Aimee Danielson ◽  
Trudi Simon ◽  
JoNell Efantis-Potter ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Genital Herpes ◽  
Herpes Virus ◽  
Immunodeficiency Virus ◽  
Herpès Virus

Infection with Genital Herpes Virus and Its Treatment in Relation to Preterm Delivery

2017 ◽  
Vol 69 (4) ◽  
pp. 2209-2214
Author(s):  
Ahmad Ayed Derham ◽  
Hanadi Hezam Al-Thobiati ◽  
Mohannad Ali Alghamdi
Keyword(s):  
Genital Herpes ◽  
Preterm Delivery ◽  
Herpes Virus ◽  
Herpès Virus
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