Loss of heterozygosity and microsatellite instability at the DCC and nm23 loci in Duke's B colorectal carcinoma

1997 ◽  
Vol 25 (1) ◽  
pp. 140S-140S
Author(s):  
KAREN LENEHAN ◽  
HUGH MULCAHY ◽  
BERNADETTE CURRAN ◽  
MARY A. BENNETT ◽  
ELAINE KAY ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Microsatellite Instability ◽  
Loss Of Heterozygosity

scholarly journals Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability

1999 ◽  
Vol 52 (7) ◽  
pp. 504-508 ◽  
Author(s):  
D. C. Fang ◽  
J. R. Jass ◽  
D. X. Wang ◽  
X. D. Zhou ◽  
Y. H. Luo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Microsatellite Instability ◽  
Loss Of Heterozygosity ◽  
Dna Microsatellite

scholarly journals Correlation between gastric carcinoma and ZAC gene-associated microsatellite instability and loss of heterozygosity

2017 ◽  
Vol 14 (2) ◽  
pp. 2422-2426
Author(s):  
Xiao-Yan Zhu ◽  
Ji-Yao Yang ◽  
Ying He ◽  
Guo-Hong Liu ◽  
Yun Sun ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Microsatellite Instability ◽  
Loss Of Heterozygosity

scholarly journals Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines

2004 ◽  
Vol 101 (2) ◽  
pp. 574-579 ◽  
Author(s):  
N. A. C. S. Wong ◽  
M. P. Britton ◽  
G. S. Choi ◽  
T. K. Stanton ◽  
D. C. Bicknell ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Loss Of Heterozygosity ◽  
Cell Lines ◽  
Promoter Methylation

scholarly journals Status of microsatellite instability in different histomorphological patterns of colorectal carcinoma among a group of Bangladeshi people

2021 ◽  
Vol 8 (12) ◽  
pp. 1799
Author(s):  
Momammed Mustafizur Rahman ◽  
Shabnam Imam ◽  
Sayedatun Nessa ◽  
A. K. M. Maruf Raza ◽  
Farida Arjuman ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Observational Study ◽  
Microsatellite Instability ◽  
University Hospital ◽  
Biological Behavior ◽  
Cancer Tissue ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Medical University

Background: This cross- sectional observational study was carried out with an aim to look for microsatellite instability (MSI) status in colorectal carcinoma and their association with different histomorphological patterns and biological behavior of colorectal carcinoma.Methods: This cross-sectional observational study was done in the Department of Pathology, Bangabandhu Sheikh Mujib Medical University Hospital (BSMMU), Dhaka, Bangladesh during September 2014 to October 2015. A total of 39 surgically resected sample of colorectal carcinoma were included. Consent from each patient was taken. The samples were histopathologically evaluated according to the standard protocol. The statistical analyses were done using Statistical packages for social sciences (SPSS 15) for Windows.Results: A total of 39 cases of colorectal carcinoma were included in this study. Majority of the patients (55.5%) was in 6th decade in MSI and 29.1% were MSI absent group. The mean age was found 47.67±10.97 years in present group and 47.84±14.26 years in absent group. The difference was not statistically significant (p>0.05). TNM stage with MSI was observed. The mean CEA level was 100.74±103.66 and 60.43±91.72. The mean Hb was 9.72±1.99 % and 9.92±2.17, the range was 7.2-12.2 and 4.6-13.4 among the groups. The mean difference was not statistically significant (p>0.05). Ulcerated was 3 (33.3%) and 19 (64.5%). Stage 3 tumor was 4 (44.4%) and 16 (51.6%). Grade 2 tumor was 5 (55.6%) and 17 (58.0%).Conclusions: For the first time in Bangladesh, this study was undertaken to evaluate the microsatellite instability (MSI) status in colorectal cancer tissue and their association with different histomorphological patterns of colorectal carcinoma.   

scholarly journals Microsatellite Instability and Loss of Heterozygosity in Melanoma

1995 ◽  
Vol 105 (4) ◽  
pp. 625-628 ◽  
Author(s):  
Ketty Peris ◽  
Gisela Keller ◽  
Sergio Chimenti ◽  
Ada Amantea ◽  
Helmut Kerl ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Loss Of Heterozygosity
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